Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence
Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grai...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vandenbulcke, Franck [verfasserIn] Pollard, Hélène [verfasserIn] Mitchell, Valérie [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1993 |
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Online-Ressource |
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2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of neuroendocrinology - Oxford [u.a.] : Wiley-Blackwell, 1989, 5(1993), 2, Seite 0 |
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volume:5 ; year:1993 ; number:2 ; pages:0 |
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| DOI / URN: |
10.1111/j.1365-2826.1993.tb00383.x |
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| 520 | |a Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. | ||
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10.1111/j.1365-2826.1993.tb00383.x doi (DE-627)NLEJ240218310 DE-627 ger DE-627 rakwb Vandenbulcke, Franck verfasserin aut Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| neutral endopeptidase Pollard, Hélène verfasserin aut Mitchell, Valérie verfasserin aut Beauvillain, Jean-Claude oth In Journal of neuroendocrinology Oxford [u.a.] : Wiley-Blackwell, 1989 5(1993), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926375 (DE-600)2007386-0 1365-2826 nnns volume:5 year:1993 number:2 pages:0 http://dx.doi.org/10.1111/j.1365-2826.1993.tb00383.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1993 2 0 |
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10.1111/j.1365-2826.1993.tb00383.x doi (DE-627)NLEJ240218310 DE-627 ger DE-627 rakwb Vandenbulcke, Franck verfasserin aut Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| neutral endopeptidase Pollard, Hélène verfasserin aut Mitchell, Valérie verfasserin aut Beauvillain, Jean-Claude oth In Journal of neuroendocrinology Oxford [u.a.] : Wiley-Blackwell, 1989 5(1993), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926375 (DE-600)2007386-0 1365-2826 nnns volume:5 year:1993 number:2 pages:0 http://dx.doi.org/10.1111/j.1365-2826.1993.tb00383.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1993 2 0 |
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10.1111/j.1365-2826.1993.tb00383.x doi (DE-627)NLEJ240218310 DE-627 ger DE-627 rakwb Vandenbulcke, Franck verfasserin aut Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| neutral endopeptidase Pollard, Hélène verfasserin aut Mitchell, Valérie verfasserin aut Beauvillain, Jean-Claude oth In Journal of neuroendocrinology Oxford [u.a.] : Wiley-Blackwell, 1989 5(1993), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926375 (DE-600)2007386-0 1365-2826 nnns volume:5 year:1993 number:2 pages:0 http://dx.doi.org/10.1111/j.1365-2826.1993.tb00383.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1993 2 0 |
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10.1111/j.1365-2826.1993.tb00383.x doi (DE-627)NLEJ240218310 DE-627 ger DE-627 rakwb Vandenbulcke, Franck verfasserin aut Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| neutral endopeptidase Pollard, Hélène verfasserin aut Mitchell, Valérie verfasserin aut Beauvillain, Jean-Claude oth In Journal of neuroendocrinology Oxford [u.a.] : Wiley-Blackwell, 1989 5(1993), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926375 (DE-600)2007386-0 1365-2826 nnns volume:5 year:1993 number:2 pages:0 http://dx.doi.org/10.1111/j.1365-2826.1993.tb00383.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1993 2 0 |
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10.1111/j.1365-2826.1993.tb00383.x doi (DE-627)NLEJ240218310 DE-627 ger DE-627 rakwb Vandenbulcke, Franck verfasserin aut Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence Oxford, UK Blackwell Publishing Ltd 1993 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| neutral endopeptidase Pollard, Hélène verfasserin aut Mitchell, Valérie verfasserin aut Beauvillain, Jean-Claude oth In Journal of neuroendocrinology Oxford [u.a.] : Wiley-Blackwell, 1989 5(1993), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926375 (DE-600)2007386-0 1365-2826 nnns volume:5 year:1993 number:2 pages:0 http://dx.doi.org/10.1111/j.1365-2826.1993.tb00383.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1993 2 0 |
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Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence neutral endopeptidase |
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radioimmunocytochemical distribution of neutral endopeptidase (enkephalinase e.g.3.4.24.11) at the ultrastructural level in the rat median eminence |
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Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence |
| abstract |
Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. |
| abstractGer |
Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. |
| abstract_unstemmed |
Neutral endopeptidase (E.G. 3.4.24.11) was visualized at the ultrastructural level in the external zone of the rat median eminence by using 125|-labelled IgG of a monoclonal serum.A precise analysis of the localization of the immunolabelling, which appears in the form of individual stray silver grains, was undertaken. Among the 1,045 grains counted, 82% were localized over membrane appositions involving nerve endings only and nerve endings plus tanycytes. The difference between the real and a randomly generated population of grains was statistically significant. Our results provide morphological arguments in support of the view of a paracrine action of neuropeptides present in the median eminence especially enkephalins but possibly, substance P, angiotensin, cholecystokinin and neurotensin. These neuropeptides are known to be inactivated by neutral endopeptidase. The action of these peptides may be exerted on nerve endings (autocrine or paracrine) but an intervention on tanycytes cannot be excluded. |
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Radioimmunocytochemical Distribution of Neutral Endopeptidase (Enkephalinase E.G.3.4.24.11) at the Ultrastructural Level in the Rat Median Eminence |
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Pollard, Hélène Mitchell, Valérie Beauvillain, Jean-Claude |
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