γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity
Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage...
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| Autor*in: |
Wolff, Johannes E. A. [verfasserIn] Belloni-Olivi, Luisa [verfasserIn] Bressler, Joseph P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1992 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 58(1992), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:58 ; year:1992 ; number:3 ; pages:0 |
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| DOI / URN: |
10.1111/j.1471-4159.1992.tb09343.x |
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| 520 | |a Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. | ||
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10.1111/j.1471-4159.1992.tb09343.x doi (DE-627)NLEJ240258150 DE-627 ger DE-627 rakwb Wolff, Johannes E. A. verfasserin aut γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Blood Belloni-Olivi, Luisa verfasserin aut Bressler, Joseph P. verfasserin aut Goldstein, Gary W. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 58(1992), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:58 year:1992 number:3 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1992.tb09343.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 58 1992 3 0 |
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10.1111/j.1471-4159.1992.tb09343.x doi (DE-627)NLEJ240258150 DE-627 ger DE-627 rakwb Wolff, Johannes E. A. verfasserin aut γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Blood Belloni-Olivi, Luisa verfasserin aut Bressler, Joseph P. verfasserin aut Goldstein, Gary W. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 58(1992), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:58 year:1992 number:3 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1992.tb09343.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 58 1992 3 0 |
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10.1111/j.1471-4159.1992.tb09343.x doi (DE-627)NLEJ240258150 DE-627 ger DE-627 rakwb Wolff, Johannes E. A. verfasserin aut γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Blood Belloni-Olivi, Luisa verfasserin aut Bressler, Joseph P. verfasserin aut Goldstein, Gary W. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 58(1992), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:58 year:1992 number:3 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1992.tb09343.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 58 1992 3 0 |
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10.1111/j.1471-4159.1992.tb09343.x doi (DE-627)NLEJ240258150 DE-627 ger DE-627 rakwb Wolff, Johannes E. A. verfasserin aut γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Blood Belloni-Olivi, Luisa verfasserin aut Bressler, Joseph P. verfasserin aut Goldstein, Gary W. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 58(1992), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:58 year:1992 number:3 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1992.tb09343.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 58 1992 3 0 |
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10.1111/j.1471-4159.1992.tb09343.x doi (DE-627)NLEJ240258150 DE-627 ger DE-627 rakwb Wolff, Johannes E. A. verfasserin aut γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity Oxford, UK Blackwell Publishing Ltd 1992 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Blood Belloni-Olivi, Luisa verfasserin aut Bressler, Joseph P. verfasserin aut Goldstein, Gary W. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 58(1992), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:58 year:1992 number:3 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1992.tb09343.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 58 1992 3 0 |
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γ-Glutamyl Transpeptidase Activity in Brain Microvessels Exhibits Regional Heterogeneity |
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Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. |
| abstractGer |
Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. |
| abstract_unstemmed |
Abstract: Brain microvessels form a tight blood-tissue permeability barrier and express high levels of specific enzymes, including γ-Glutamyl transpeptidase (GGTP). This differentiation is thought to be induced by perivascular astrocytes. By using histochemical methods, we found that the percentage of GGTP-positive vessels varied considerably in different areas of rat brain. Enzyme activity was not found in the pineal gland or the median eminence, where the blood-brain barrier is not expressed. In areas where the blood-brain barrier is expressed, the percentage of GGTP-positive vessels varied from 8% in the optic nerve to 100% in the anterior commissure. The neocortex showed a lower percentage of GGTP-positive vessels (2-15%) than anterior olfactory nucleus (42%), subiculum (70%), hippocampus (48%), and striatum (50-58%). Alkaline phosphatase, another brain microvessel-enriched enzyme, did not show these marked regional differences. The morphometric histochemical results were verified by enzymatic assays in homogenates of different regions from rat and bovine brain and in microvessel preparations of bovine putamen and neocortex. During the postnatal development of rat brain, the difference between neocortex and striatum appeared after day 20. The regional heterogeneity of brain microvessels may be caused by astrocytic heterogeneity and reflect regional heterogeneity in microvascular function. |
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