1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities
In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tet...
Ausführliche Beschreibung
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| Autor*in: |
Tasaki, Yoshikazu [verfasserIn] Makino, Yukiko [verfasserIn] Ohta, Shigeru [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1991 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 57(1991), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:57 ; year:1991 ; number:6 ; pages:0 |
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| DOI / URN: |
10.1111/j.1471-4159.1991.tb06407.x |
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10.1111/j.1471-4159.1991.tb06407.x doi (DE-627)NLEJ240259831 DE-627 ger DE-627 rakwb Tasaki, Yoshikazu verfasserin aut 1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| 1,2,3,4-Tetrahydroisoquinoline—1- Methyl -1,2,3,4-tetrahydroisoquinoline—1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine—Parkinsonism—Antiparldnsonism agents—Behavior abnormalities Makino, Yukiko verfasserin aut Ohta, Shigeru verfasserin aut Hirobe, Masaaki oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb06407.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 6 0 |
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10.1111/j.1471-4159.1991.tb06407.x doi (DE-627)NLEJ240259831 DE-627 ger DE-627 rakwb Tasaki, Yoshikazu verfasserin aut 1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| 1,2,3,4-Tetrahydroisoquinoline—1- Methyl -1,2,3,4-tetrahydroisoquinoline—1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine—Parkinsonism—Antiparldnsonism agents—Behavior abnormalities Makino, Yukiko verfasserin aut Ohta, Shigeru verfasserin aut Hirobe, Masaaki oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb06407.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 6 0 |
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10.1111/j.1471-4159.1991.tb06407.x doi (DE-627)NLEJ240259831 DE-627 ger DE-627 rakwb Tasaki, Yoshikazu verfasserin aut 1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| 1,2,3,4-Tetrahydroisoquinoline—1- Methyl -1,2,3,4-tetrahydroisoquinoline—1-Methyl-4-phenyl-1,2,3,6- tetrahydropyridine—Parkinsonism—Antiparldnsonism agents—Behavior abnormalities Makino, Yukiko verfasserin aut Ohta, Shigeru verfasserin aut Hirobe, Masaaki oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb06407.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 6 0 |
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Elektronische Aufsätze |
| author-letter |
Tasaki, Yoshikazu |
| doi_str_mv |
10.1111/j.1471-4159.1991.tb06407.x |
| author2-role |
verfasserin |
| title_sort |
1-methyl- 1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities |
| title_auth |
1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities |
| abstract |
In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. |
| abstractGer |
In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. |
| abstract_unstemmed |
In l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine (MPTP)-treated mouse brain, there was no significant increase or decrease in the content of an endogenous amine, 1,2,3,4-tctrahydroisoquinoline (TIQ), which is well noted for inducing parkinsonism, whereas another endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline (1-MeTIQ), was markedly reduced. This result agrees with the finding in human idiopathic parkinsonianism, confirmed by our previous research. In addition, pretreatment with 1-MeTIQ completely prevented MPTP- or TIQ-inducing bradykinesia, a symptom of parldnsonism. This study confirmed that 1-MeTIQ plays an important role in preventing the pathogenesis of parldnsonism and is a possible leading compound of anti-parkinsonism agents. |
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| title_short |
1-Methyl- 1,2,3,4-Tetrahydroisoquinoline, Decreasing in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Treated Mouse, Prevents Parkinsonism-Like Behavior Abnormalities |
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http://dx.doi.org/10.1111/j.1471-4159.1991.tb06407.x |
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| author2 |
Makino, Yukiko Ohta, Shigeru Hirobe, Masaaki |
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Makino, Yukiko Ohta, Shigeru Hirobe, Masaaki |
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| doi_str |
10.1111/j.1471-4159.1991.tb06407.x |
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2024-07-06T09:30:11.044Z |
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7.399296 |