Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus
Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway pro...
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Oxford, UK: Blackwell Publishing Ltd ; 1991 |
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2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 57(1991), 2, Seite 0 |
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volume:57 ; year:1991 ; number:2 ; pages:0 |
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DOI / URN: |
10.1111/j.1471-4159.1991.tb03763.x |
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10.1111/j.1471-4159.1991.tb03763.x doi (DE-627)NLEJ24026178X DE-627 ger DE-627 rakwb Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Aronica, E. oth Frey, U. oth Wagner, M. oth Schroeder, H. oth Krug, M. oth Ruthrich, H. oth Catania, M. V. oth Nicoletti, F. oth Reymann, K. G. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:2 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 2 0 |
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10.1111/j.1471-4159.1991.tb03763.x doi (DE-627)NLEJ24026178X DE-627 ger DE-627 rakwb Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Aronica, E. oth Frey, U. oth Wagner, M. oth Schroeder, H. oth Krug, M. oth Ruthrich, H. oth Catania, M. V. oth Nicoletti, F. oth Reymann, K. G. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:2 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 2 0 |
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10.1111/j.1471-4159.1991.tb03763.x doi (DE-627)NLEJ24026178X DE-627 ger DE-627 rakwb Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Aronica, E. oth Frey, U. oth Wagner, M. oth Schroeder, H. oth Krug, M. oth Ruthrich, H. oth Catania, M. V. oth Nicoletti, F. oth Reymann, K. G. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:2 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 2 0 |
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10.1111/j.1471-4159.1991.tb03763.x doi (DE-627)NLEJ24026178X DE-627 ger DE-627 rakwb Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Aronica, E. oth Frey, U. oth Wagner, M. oth Schroeder, H. oth Krug, M. oth Ruthrich, H. oth Catania, M. V. oth Nicoletti, F. oth Reymann, K. G. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:2 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 2 0 |
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10.1111/j.1471-4159.1991.tb03763.x doi (DE-627)NLEJ24026178X DE-627 ger DE-627 rakwb Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Aronica, E. oth Frey, U. oth Wagner, M. oth Schroeder, H. oth Krug, M. oth Ruthrich, H. oth Catania, M. V. oth Nicoletti, F. oth Reymann, K. G. oth In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 57(1991), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:57 year:1991 number:2 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 57 1991 2 0 |
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enhanced sensitivity of “metabotropic” glutamate receptors after induction of long-term potentiation in rat hippocampus |
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Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus |
abstract |
Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. |
abstractGer |
Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. |
abstract_unstemmed |
Stimulation of [3H]inositol monophosphate <[3H]InsP) formation by ibotenate or trans-1-aminocyclopentyl-l, 3-dicarboxylic acid (t-ACPD) in rat hippocampal slices was enhanced after tetanic stimulation of die Schaffer collaterals projecting to the CA1 region (in vitro) or the perforant pathway projecting to the dentate gyms (in freely moving animals). This effect was observed 5 h (but not 2 h) after long-term potentiation (LTP) induction and was abolished if tetanic stimulation was performed in the presence of specific antagonists of N-methyl-D-aspartate receptors. The delayed increase in excitatory amino acid-induced polyphosphoinositide (PPI) hydrolysis was accompanied by an enhanced responsiveness to norepinephrine, whereas the basal and carbamylcholine-stimulated [3H]InsP formation were unchanged. These results suggest that an increased activity of „metabotropic” glutamate receptors may contribute to the synaptic mechanisms enabling the late expression and or maintenance of LTP. Accordingly, LTP decayed more rapidly (within 5 h) in rats repeatedly injected with LiCl (60–120 mg/kg, i.p., for 10 days), a treatment that led to a reduced efficacy of ibotenate and norepinephrine in stimulating PPI hydrolysis in hippocampal slices. |
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title_short |
Enhanced Sensitivity of “Metabotropic” Glutamate Receptors After Induction of Long-Term Potentiation in Rat Hippocampus |
url |
http://dx.doi.org/10.1111/j.1471-4159.1991.tb03763.x |
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Aronica, E. Frey, U. Wagner, M. Schroeder, H. Krug, M. Ruthrich, H. Catania, M. V. Nicoletti, F. Reymann, K. G. |
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Aronica, E. Frey, U. Wagner, M. Schroeder, H. Krug, M. Ruthrich, H. Catania, M. V. Nicoletti, F. Reymann, K. G. |
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up_date |
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