Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors?
Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino-...
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| Autor*in: |
Alexander, Stephen P. H. [verfasserIn] Hill, Stephen J. [verfasserIn] Kendall, David A. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1990 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 55(1990), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:55 ; year:1990 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1471-4159.1990.tb03158.x |
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| 520 | |a Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. | ||
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10.1111/j.1471-4159.1990.tb03158.x doi (DE-627)NLEJ240267362 DE-627 ger DE-627 rakwb Alexander, Stephen P. H. verfasserin aut Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Hill, Stephen J. verfasserin aut Kendall, David A. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 55(1990), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:55 year:1990 number:4 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 55 1990 4 0 |
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10.1111/j.1471-4159.1990.tb03158.x doi (DE-627)NLEJ240267362 DE-627 ger DE-627 rakwb Alexander, Stephen P. H. verfasserin aut Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Hill, Stephen J. verfasserin aut Kendall, David A. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 55(1990), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:55 year:1990 number:4 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 55 1990 4 0 |
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10.1111/j.1471-4159.1990.tb03158.x doi (DE-627)NLEJ240267362 DE-627 ger DE-627 rakwb Alexander, Stephen P. H. verfasserin aut Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Hill, Stephen J. verfasserin aut Kendall, David A. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 55(1990), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:55 year:1990 number:4 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 55 1990 4 0 |
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10.1111/j.1471-4159.1990.tb03158.x doi (DE-627)NLEJ240267362 DE-627 ger DE-627 rakwb Alexander, Stephen P. H. verfasserin aut Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Hill, Stephen J. verfasserin aut Kendall, David A. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 55(1990), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:55 year:1990 number:4 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 55 1990 4 0 |
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10.1111/j.1471-4159.1990.tb03158.x doi (DE-627)NLEJ240267362 DE-627 ger DE-627 rakwb Alexander, Stephen P. H. verfasserin aut Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? Oxford, UK Blackwell Publishing Ltd 1990 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate Hill, Stephen J. verfasserin aut Kendall, David A. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 55(1990), 4, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:55 year:1990 number:4 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 55 1990 4 0 |
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excitatory amino acid-induced formation of inositol phosphates in guinea-pig cerebral cortical slices: involvement of ionotropic or metabotropic receptors? |
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Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? |
| abstract |
Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. |
| abstractGer |
Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. |
| abstract_unstemmed |
Abstract: In cerebral cortical slices from the guinea-pig, quinoxalinedione derivatives antagonised the generation of 3H-inositol phosphates evoked by the excitatory amino acids quisqualate and DL-α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid but were without effect on the trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid and l-glutamate responses. Omission of calcium from the medium reduced the accumulation of 3H-inositol phosphates induced by incubation with trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid (incubation for 45 min) by > 50%, whereas the responses to l-glutamate and the two other amino acid analogues were reduced by ∼20%. Generation of inositol 1,4,5-trisphosphate over a 30-s period by treatment with quisqualate, trans-DL-1-amino- 1,3-cyclopentanedicarboxylic acid, KCI, and carbachol was abolished in the presence of nominally calcium-free medium. l-Glutamate induced a large, rapid increase in inositol 1,4,5-trisphosphate mass (more than threefold), which was, however, unaffected by omission of calcium from the medium. These results indicate that of the excitatory amino acids tested, only l-glutamate may be classed as a metabotropic receptor agonist in guinea-pig cerebral cortical slices with respect to generation of inositol phosphates. The other agents appear to stimulate accumulation of inositol phosphates, at least in part through some mechanism requiring the presence of extracellular Ca2+, presumably Ca2+ entry. |
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| title_short |
Excitatory Amino Acid-Induced Formation of Inositol Phosphates in Guinea-Pig Cerebral Cortical Slices: Involvement of Ionotropic or Metabotropic Receptors? |
| url |
http://dx.doi.org/10.1111/j.1471-4159.1990.tb03158.x |
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| author2 |
Hill, Stephen J. Kendall, David A. |
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| doi_str |
10.1111/j.1471-4159.1990.tb03158.x |
| up_date |
2024-07-06T09:31:47.437Z |
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