Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes
Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The...
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Gespeichert in:
| Autor*in: |
Tibbs, Gareth R. [verfasserIn] Dolly, J. Oliver [verfasserIn] Nicholls, David G. [verfasserIn] |
|---|
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1989 |
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Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 52(1989), 1, Seite 0 |
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volume:52 ; year:1989 ; number:1 ; pages:0 |
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| DOI / URN: |
10.1111/j.1471-4159.1989.tb10917.x |
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| 520 | |a Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. | ||
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10.1111/j.1471-4159.1989.tb10917.x doi (DE-627)NLEJ24027783X DE-627 ger DE-627 rakwb Tibbs, Gareth R. verfasserin aut Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate release Dolly, J. Oliver verfasserin aut Nicholls, David G. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 52(1989), 1, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:52 year:1989 number:1 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1989.tb10917.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 52 1989 1 0 |
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10.1111/j.1471-4159.1989.tb10917.x doi (DE-627)NLEJ24027783X DE-627 ger DE-627 rakwb Tibbs, Gareth R. verfasserin aut Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate release Dolly, J. Oliver verfasserin aut Nicholls, David G. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 52(1989), 1, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:52 year:1989 number:1 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1989.tb10917.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 52 1989 1 0 |
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10.1111/j.1471-4159.1989.tb10917.x doi (DE-627)NLEJ24027783X DE-627 ger DE-627 rakwb Tibbs, Gareth R. verfasserin aut Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate release Dolly, J. Oliver verfasserin aut Nicholls, David G. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 52(1989), 1, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:52 year:1989 number:1 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1989.tb10917.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 52 1989 1 0 |
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10.1111/j.1471-4159.1989.tb10917.x doi (DE-627)NLEJ24027783X DE-627 ger DE-627 rakwb Tibbs, Gareth R. verfasserin aut Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate release Dolly, J. Oliver verfasserin aut Nicholls, David G. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 52(1989), 1, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:52 year:1989 number:1 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1989.tb10917.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 52 1989 1 0 |
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10.1111/j.1471-4159.1989.tb10917.x doi (DE-627)NLEJ24027783X DE-627 ger DE-627 rakwb Tibbs, Gareth R. verfasserin aut Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Glutamate release Dolly, J. Oliver verfasserin aut Nicholls, David G. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 52(1989), 1, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:52 year:1989 number:1 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1989.tb10917.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 52 1989 1 0 |
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Tibbs, Gareth R. misc Glutamate release Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes |
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Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes Glutamate release |
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dendrotoxin, 4-aminopyridine, and β-bungarotoxin act at common loci but by two distinct mechanisms to induce ca2+-dependent release of glutamate from guinea-pig cerebrocortical synaptosomes |
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Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes |
| abstract |
Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. |
| abstractGer |
Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. |
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Abstract: The release of endogenous glutamate from guineapig cerebrocortical synaptosomes evoked by dendrotoxin, β-bungarotoxin, and 4-aminopyridine is compared. Dendrotoxin and 4-aminopyridine cause Ca2+-dependent release, representing a partial depletion of the KCl-releasable transmitter pool. The decrease in the plasma membrane potential caused by 4-aminopyridine or dendrotoxin and the evoked release of glutamate from a transmitter pool accord with the inhibitory action of these agents on certain K+ conductances. In contrast, the massive release of glutamate evoked by β-bungarotoxin is produced in the presence of Ca2+ but not of Sr2+, a result consistent with a generalised permeabilisation of synaptosomal plasma membranes. Although dendrotoxin inhibits the binding of β-bungarotoxin and the resultant synaptosomal lysis, demonstration of a direct effect of β-bungarotoxin binding per se on K+ permeability is impractical owing to its phospholipase A2 activity. |
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Dendrotoxin, 4-Aminopyridine, and β-Bungarotoxin Act at Common Loci but by Two Distinct Mechanisms to Induce Ca2+-Dependent Release of Glutamate from Guinea-Pig Cerebrocortical Synaptosomes |
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Dolly, J. Oliver Nicholls, David G. |
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10.1111/j.1471-4159.1989.tb10917.x |
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