Binding of Chlorpromazine to S-100 Protein
Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Donato, Rosario [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1984 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 42(1984), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:42 ; year:1984 ; number:5 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1471-4159.1984.tb02811.x |
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NLEJ240305396 |
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| 520 | |a Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. | ||
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10.1111/j.1471-4159.1984.tb02811.x doi (DE-627)NLEJ240305396 DE-627 ger DE-627 rakwb Donato, Rosario verfasserin aut Binding of Chlorpromazine to S-100 Protein Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| S-100 protein In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 42(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:42 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb02811.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 1984 5 0 |
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10.1111/j.1471-4159.1984.tb02811.x doi (DE-627)NLEJ240305396 DE-627 ger DE-627 rakwb Donato, Rosario verfasserin aut Binding of Chlorpromazine to S-100 Protein Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| S-100 protein In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 42(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:42 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb02811.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 1984 5 0 |
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10.1111/j.1471-4159.1984.tb02811.x doi (DE-627)NLEJ240305396 DE-627 ger DE-627 rakwb Donato, Rosario verfasserin aut Binding of Chlorpromazine to S-100 Protein Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| S-100 protein In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 42(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:42 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb02811.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 1984 5 0 |
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10.1111/j.1471-4159.1984.tb02811.x doi (DE-627)NLEJ240305396 DE-627 ger DE-627 rakwb Donato, Rosario verfasserin aut Binding of Chlorpromazine to S-100 Protein Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| S-100 protein In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 42(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:42 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb02811.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 1984 5 0 |
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10.1111/j.1471-4159.1984.tb02811.x doi (DE-627)NLEJ240305396 DE-627 ger DE-627 rakwb Donato, Rosario verfasserin aut Binding of Chlorpromazine to S-100 Protein Oxford, UK Blackwell Publishing Ltd 1984 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| S-100 protein In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 42(1984), 5, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:42 year:1984 number:5 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1984.tb02811.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 1984 5 0 |
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Binding of Chlorpromazine to S-100 Protein |
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Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. |
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Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. |
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Abstract: Chlorpromazine (CPZ) induces in S-100 conformational changes resulting in the exposure of titratable SH groups of the protein to the solvent. This effect is even greater in the presence of Mg2+± Ca2+. S-100 possesses binding sites for CPZ. The binding of CPZ to 3 μM S-100 is half-saturated by 0.18 μM CPZ in the presence of Mg2+ plus Ca2+ and by 0.24 μM CPZ in the presence of Mg2+ plus EGTA. The extent of the binding is greater in the presence of Ca2+ than in the presence of EGTA, especially at low CPZ concentrations. |
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