INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY
—The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosin...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kuczenski, R. [verfasserIn] Segal, D. S. [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1974 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Journal of neurochemistry - Oxford : Wiley-Blackwell, 1956, 22(1974), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:22 ; year:1974 ; number:6 ; pages:0 |
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| DOI / URN: |
10.1111/j.1471-4159.1974.tb04334.x |
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| 520 | |a —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. | ||
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10.1111/j.1471-4159.1974.tb04334.x doi (DE-627)NLEJ240353730 DE-627 ger DE-627 rakwb Kuczenski, R. verfasserin aut INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY Oxford, UK Blackwell Publishing Ltd 1974 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Segal, D. S. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 22(1974), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:22 year:1974 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1974 6 0 |
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10.1111/j.1471-4159.1974.tb04334.x doi (DE-627)NLEJ240353730 DE-627 ger DE-627 rakwb Kuczenski, R. verfasserin aut INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY Oxford, UK Blackwell Publishing Ltd 1974 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Segal, D. S. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 22(1974), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:22 year:1974 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1974 6 0 |
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10.1111/j.1471-4159.1974.tb04334.x doi (DE-627)NLEJ240353730 DE-627 ger DE-627 rakwb Kuczenski, R. verfasserin aut INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY Oxford, UK Blackwell Publishing Ltd 1974 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Segal, D. S. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 22(1974), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:22 year:1974 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1974 6 0 |
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10.1111/j.1471-4159.1974.tb04334.x doi (DE-627)NLEJ240353730 DE-627 ger DE-627 rakwb Kuczenski, R. verfasserin aut INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY Oxford, UK Blackwell Publishing Ltd 1974 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Segal, D. S. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 22(1974), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:22 year:1974 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1974 6 0 |
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10.1111/j.1471-4159.1974.tb04334.x doi (DE-627)NLEJ240353730 DE-627 ger DE-627 rakwb Kuczenski, R. verfasserin aut INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY Oxford, UK Blackwell Publishing Ltd 1974 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier —The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Segal, D. S. verfasserin aut In Journal of neurochemistry Oxford : Wiley-Blackwell, 1956 22(1974), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927584 (DE-600)2020528-4 1471-4159 nnns volume:22 year:1974 number:6 pages:0 http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 22 1974 6 0 |
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INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY |
| abstract |
—The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. |
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—The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. |
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—The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ240353730</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707110657.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120426s1974 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1471-4159.1974.tb04334.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ240353730</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kuczenski, R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">INTRASYNAPTOSOMAL CONVERSION OF TYROSINE TO DOPAMINE AS AN INDEX OF BRAIN CATECHOLAMINE BIOSYNTHETIC CAPACITY</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1974</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">—The potential for intrasynaptosomal conversion of tyrosine to dopamine was evaluated in the cell bodies (substantia nigra) and nerve terminals (caudate-putamen) of the nigral-striatal dopaminergic pathway. The conversion technique involves measurement of 14CO2 evolved from carboxyl-labelled tyrosine in the absence of both exogenous pteridine cofactor and DOPA decarboxylase. Evaluation of apparent Km values for tyrosine uptake and conversion and observed maximal velocities suggest that conversion is not limited by movement of substrate into the synaptosomes. The results, based on brain regional and subcellular distribution, are consistent with the localization of conversion in nerve endings and suggest a rapid and reliable measure for catecholamine biosynthetic capacity when structural integrity of the nerve ending is maintained.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Segal, D. S.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Journal of neurochemistry</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1956</subfield><subfield code="g">22(1974), 6, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927584</subfield><subfield code="w">(DE-600)2020528-4</subfield><subfield code="x">1471-4159</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:22</subfield><subfield code="g">year:1974</subfield><subfield code="g">number:6</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1471-4159.1974.tb04334.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">22</subfield><subfield code="j">1974</subfield><subfield code="e">6</subfield><subfield code="h">0</subfield></datafield></record></collection>
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