Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs
Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 2...
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| Autor*in: |
BUCKINGHAM, THOMAS A. - M.D. [verfasserIn] BHUTTO, ZAHIDA R. - M.D. [verfasserIn] TELFER, EDWARD A. - M.D. [verfasserIn] ZBILUT, JOSEPH - PH.D., D.N.Sc. |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1994 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 5(1994), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:5 ; year:1994 ; number:5 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1540-8167.1994.tb01179.x |
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| 520 | |a Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. | ||
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10.1111/j.1540-8167.1994.tb01179.x doi (DE-627)NLEJ240760581 DE-627 ger DE-627 rakwb BUCKINGHAM, THOMAS A. M.D. verfasserin aut Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| polymorphic ventricular tachycardia BHUTTO, ZAHIDA R. M.D. verfasserin aut TELFER, EDWARD A. M.D. verfasserin aut ZBILUT, JOSEPH PH.D., D.N.Sc. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 5(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:5 year:1994 number:5 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1994.tb01179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1994 5 0 |
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10.1111/j.1540-8167.1994.tb01179.x doi (DE-627)NLEJ240760581 DE-627 ger DE-627 rakwb BUCKINGHAM, THOMAS A. M.D. verfasserin aut Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| polymorphic ventricular tachycardia BHUTTO, ZAHIDA R. M.D. verfasserin aut TELFER, EDWARD A. M.D. verfasserin aut ZBILUT, JOSEPH PH.D., D.N.Sc. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 5(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:5 year:1994 number:5 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1994.tb01179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1994 5 0 |
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10.1111/j.1540-8167.1994.tb01179.x doi (DE-627)NLEJ240760581 DE-627 ger DE-627 rakwb BUCKINGHAM, THOMAS A. M.D. verfasserin aut Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| polymorphic ventricular tachycardia BHUTTO, ZAHIDA R. M.D. verfasserin aut TELFER, EDWARD A. M.D. verfasserin aut ZBILUT, JOSEPH PH.D., D.N.Sc. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 5(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:5 year:1994 number:5 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1994.tb01179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1994 5 0 |
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10.1111/j.1540-8167.1994.tb01179.x doi (DE-627)NLEJ240760581 DE-627 ger DE-627 rakwb BUCKINGHAM, THOMAS A. M.D. verfasserin aut Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| polymorphic ventricular tachycardia BHUTTO, ZAHIDA R. M.D. verfasserin aut TELFER, EDWARD A. M.D. verfasserin aut ZBILUT, JOSEPH PH.D., D.N.Sc. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 5(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:5 year:1994 number:5 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1994.tb01179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1994 5 0 |
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10.1111/j.1540-8167.1994.tb01179.x doi (DE-627)NLEJ240760581 DE-627 ger DE-627 rakwb BUCKINGHAM, THOMAS A. M.D. verfasserin aut Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs Oxford, UK Blackwell Publishing Ltd 1994 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| polymorphic ventricular tachycardia BHUTTO, ZAHIDA R. M.D. verfasserin aut TELFER, EDWARD A. M.D. verfasserin aut ZBILUT, JOSEPH PH.D., D.N.Sc. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 5(1994), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:5 year:1994 number:5 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1994.tb01179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 1994 5 0 |
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Journal of cardiovascular electrophysiology |
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Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs |
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(DE-627)NLEJ240760581 |
| title_full |
Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs |
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BUCKINGHAM, THOMAS A. M.D. |
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Journal of cardiovascular electrophysiology |
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1994 |
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BUCKINGHAM, THOMAS A. BHUTTO, ZAHIDA R. TELFER, EDWARD A. |
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5 |
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Elektronische Aufsätze |
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BUCKINGHAM, THOMAS A. |
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10.1111/j.1540-8167.1994.tb01179.x |
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verfasserin |
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differences in corrected qt intervals at minimal and maximal heart rate may identify patients at risk for torsades de pointes during treatment with antiarrhythmic drugs |
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Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs |
| abstract |
Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. |
| abstractGer |
Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. |
| abstract_unstemmed |
Change in QT Interval with HR May Predict Torsades. The mechanism of torsades de pointes as a proarrhythmic response to antiarrhythmic drugs is not clear. We hypothesized that the difference in the corrected QT interval (QTc, Bazett's formula) with varying autonomic tone and heart rate during 24-hour ambulatory ECG would help identify patients at risk. Ten patients with antiarrhythmic drug-induced torsades de pointes were compared with 28 controls. The QTc. at maximal and minimal heart rate during antiarrhythmic drug-free ambulatory ECGs were measured. The mean QTc, at minimal heart rates for patients was 0.413 ± (KI02 seconds and 0.420 ± 0.072 seconds for controls (P = 0.715). The mean QTc, at maximal heart rates for patients was 0.555 ± 0.022 seconds and for controls was 0.439 ± 0.011 seconds (P = 0.00l). Mean QTc, between minimal and maximal heart rates were significantly different for patients (P = 0.015) but were not for controls (P = 0.151). Using an arbitrary QT, difference cutoff of 0.075 seconds, this approach identified patients at risk for antiarrhythmic drug-induced torsades de pointes with a sensitivity of 70% (7 of 10) and a specificity of 89% (P < 0.003 by Chi-square analysis with Vales’ correction). In conclusion, patients with antiarrhythmic drug-induced torsades de pointes had a greater rise in QTc, from minimal to maximal heart rate during ambulatory ECG than controls. Further larger prospective trials will be required to establish the value of this approach to identify patients at risk for this type of proarrhythmia. |
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Differences in Corrected QT Intervals at Minimal and Maximal Heart Rate May Identify Patients at Risk for Torsades de Pointes During Treatment with Antiarrhythmic Drugs |
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BHUTTO, ZAHIDA R. M.D. TELFER, EDWARD A. M.D. ZBILUT, JOSEPH PH.D., D.N.Sc |
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