The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium
Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryode...
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| Autor*in: |
BOERSMA, LUCAS - M.D. [verfasserIn] BRUGADA, JOSEP - M.D. [verfasserIn] SCHALIJ, MARTIN JAN - M.D. [verfasserIn] KIRCHHOF, CHARLES - M.D. ALLESSIE, MAURITS - M.D. |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1991 |
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Online-Ressource |
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| Reproduktion: |
2008 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of cardiovascular electrophysiology - Oxford : Wiley-Blackwell, 1990, 2(1991), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:2 ; year:1991 ; number:6 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1540-8167.1991.tb01351.x |
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NLEJ240763084 |
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| 520 | |a Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. | ||
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10.1111/j.1540-8167.1991.tb01351.x doi (DE-627)NLEJ240763084 DE-627 ger DE-627 rakwb BOERSMA, LUCAS M.D. verfasserin aut The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| fiber orientation BRUGADA, JOSEP M.D. verfasserin aut SCHALIJ, MARTIN JAN M.D. verfasserin aut KIRCHHOF, CHARLES M.D. oth ALLESSIE, MAURITS M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 2(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:2 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1991.tb01351.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1991 6 0 |
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10.1111/j.1540-8167.1991.tb01351.x doi (DE-627)NLEJ240763084 DE-627 ger DE-627 rakwb BOERSMA, LUCAS M.D. verfasserin aut The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| fiber orientation BRUGADA, JOSEP M.D. verfasserin aut SCHALIJ, MARTIN JAN M.D. verfasserin aut KIRCHHOF, CHARLES M.D. oth ALLESSIE, MAURITS M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 2(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:2 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1991.tb01351.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1991 6 0 |
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10.1111/j.1540-8167.1991.tb01351.x doi (DE-627)NLEJ240763084 DE-627 ger DE-627 rakwb BOERSMA, LUCAS M.D. verfasserin aut The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| fiber orientation BRUGADA, JOSEP M.D. verfasserin aut SCHALIJ, MARTIN JAN M.D. verfasserin aut KIRCHHOF, CHARLES M.D. oth ALLESSIE, MAURITS M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 2(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:2 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1991.tb01351.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1991 6 0 |
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10.1111/j.1540-8167.1991.tb01351.x doi (DE-627)NLEJ240763084 DE-627 ger DE-627 rakwb BOERSMA, LUCAS M.D. verfasserin aut The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| fiber orientation BRUGADA, JOSEP M.D. verfasserin aut SCHALIJ, MARTIN JAN M.D. verfasserin aut KIRCHHOF, CHARLES M.D. oth ALLESSIE, MAURITS M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 2(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:2 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1991.tb01351.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1991 6 0 |
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10.1111/j.1540-8167.1991.tb01351.x doi (DE-627)NLEJ240763084 DE-627 ger DE-627 rakwb BOERSMA, LUCAS M.D. verfasserin aut The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. 2008 Blackwell Publishing Journal Backfiles 1879-2005 |2008|||||||||| fiber orientation BRUGADA, JOSEP M.D. verfasserin aut SCHALIJ, MARTIN JAN M.D. verfasserin aut KIRCHHOF, CHARLES M.D. oth ALLESSIE, MAURITS M.D. oth In Journal of cardiovascular electrophysiology Oxford : Wiley-Blackwell, 1990 2(1991), 6, Seite 0 Online-Ressource (DE-627)NLEJ243926243 (DE-600)2037519-0 1540-8167 nnns volume:2 year:1991 number:6 pages:0 http://dx.doi.org/10.1111/j.1540-8167.1991.tb01351.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 2 1991 6 0 |
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Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). 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Journal of cardiovascular electrophysiology |
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Journal of cardiovascular electrophysiology |
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1991 |
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BOERSMA, LUCAS BRUGADA, JOSEP SCHALIJ, MARTIN JAN |
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Elektronische Aufsätze |
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BOERSMA, LUCAS |
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10.1111/j.1540-8167.1991.tb01351.x |
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verfasserin |
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the effects of k+ on anisotropic conduction in sheets of perfused rabbit ventricular epicardium |
| title_auth |
The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium |
| abstract |
Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. |
| abstractGer |
Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. |
| abstract_unstemmed |
Potassium and Anisotropy. Introduction: The purpose of this study was to investigate the effects of potassium on anisotropic conduction in rabbit ventricles. Methods and Results: In Langendorff perfused rabbit hearts, a two-dimensional epicardial layer of anisotropic myocardium was created by cryodestruction of the endocardial four fifths of the left ventricle. The heart was paced at 0.5 Hz and the epicardial spread of activation was recorded with a high-resolution mapping electrode (240 points). In ten experiments, we studied the effects of stepwise increased concentrations of extracellular potassium on epicardial conduction, longitudinal and transverse to the fiber direction. At 6.2 mM of K+, longitudinal conduction velocity (θL) was 61 ± 6.2 and transverse conduction velocity (θT) 25 ± 4.6 cm/sec with a ratio θL/θT of 2.6. At a high concentration of 12.5 ± 1.1 mM, conduction slowed down to 29 ± 6.0 and 11 ± 4.4 cm/sec, respectively, with a slightly increased ratio of 3.2 (NS). The amount of depression of θL and θT varied considerably from experiment to experiment and from region to region. On the average, no statistical difference in the depression of conduction velocity in relation to the fiber orientation was found. At K + concentrations of more than 12.5 ± 1.1 mM, local conduction was seriously impaired at various sites. Lines of functional conduction block appeared in longitudinal and transverse direction. Conclusion: We conclude that during slow heart rates, depression of the fast sodium channels by high extracellular K + causes no detectable differential effects on conduction velocity or on occurrence of conduction block, longitudinal or transverse to the general fiber orientation. |
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The Effects of K+ on Anisotropic Conduction in Sheets of Perfused Rabbit Ventricular Epicardium |
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BRUGADA, JOSEP M.D. SCHALIJ, MARTIN JAN M.D. KIRCHHOF, CHARLES M.D. ALLESSIE, MAURITS M.D. |
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BRUGADA, JOSEP M.D. SCHALIJ, MARTIN JAN M.D. KIRCHHOF, CHARLES M.D. ALLESSIE, MAURITS M.D. |
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