Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA
The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells...
Ausführliche Beschreibung
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| Autor*in: |
Goff, L. [verfasserIn] Roussaux, J. [verfasserIn] Cunha, M. I. Aaron-da [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1985 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Physiologia plantarum - Oxford [u.a.] : Wiley-Blackwell, 1948, 64(1985), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:64 ; year:1985 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1399-3054.1985.tb02332.x |
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NLEJ240972511 |
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| 520 | |a The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. | ||
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10.1111/j.1399-3054.1985.tb02332.x doi (DE-627)NLEJ240972511 DE-627 ger DE-627 rakwb Goff, L. verfasserin aut Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Anti-cancer drug Roussaux, J. verfasserin aut Cunha, M. I. Aaron-da verfasserin aut Beljanski, M. oth In Physiologia plantarum Oxford [u.a.] : Wiley-Blackwell, 1948 64(1985), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927738 (DE-600)2020837-6 1399-3054 nnns volume:64 year:1985 number:2 pages:0 http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 64 1985 2 0 |
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10.1111/j.1399-3054.1985.tb02332.x doi (DE-627)NLEJ240972511 DE-627 ger DE-627 rakwb Goff, L. verfasserin aut Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Anti-cancer drug Roussaux, J. verfasserin aut Cunha, M. I. Aaron-da verfasserin aut Beljanski, M. oth In Physiologia plantarum Oxford [u.a.] : Wiley-Blackwell, 1948 64(1985), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927738 (DE-600)2020837-6 1399-3054 nnns volume:64 year:1985 number:2 pages:0 http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 64 1985 2 0 |
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10.1111/j.1399-3054.1985.tb02332.x doi (DE-627)NLEJ240972511 DE-627 ger DE-627 rakwb Goff, L. verfasserin aut Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Anti-cancer drug Roussaux, J. verfasserin aut Cunha, M. I. Aaron-da verfasserin aut Beljanski, M. oth In Physiologia plantarum Oxford [u.a.] : Wiley-Blackwell, 1948 64(1985), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927738 (DE-600)2020837-6 1399-3054 nnns volume:64 year:1985 number:2 pages:0 http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 64 1985 2 0 |
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10.1111/j.1399-3054.1985.tb02332.x doi (DE-627)NLEJ240972511 DE-627 ger DE-627 rakwb Goff, L. verfasserin aut Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Anti-cancer drug Roussaux, J. verfasserin aut Cunha, M. I. Aaron-da verfasserin aut Beljanski, M. oth In Physiologia plantarum Oxford [u.a.] : Wiley-Blackwell, 1948 64(1985), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927738 (DE-600)2020837-6 1399-3054 nnns volume:64 year:1985 number:2 pages:0 http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 64 1985 2 0 |
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10.1111/j.1399-3054.1985.tb02332.x doi (DE-627)NLEJ240972511 DE-627 ger DE-627 rakwb Goff, L. verfasserin aut Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA Oxford, UK Blackwell Publishing Ltd 1985 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Anti-cancer drug Roussaux, J. verfasserin aut Cunha, M. I. Aaron-da verfasserin aut Beljanski, M. oth In Physiologia plantarum Oxford [u.a.] : Wiley-Blackwell, 1948 64(1985), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927738 (DE-600)2020837-6 1399-3054 nnns volume:64 year:1985 number:2 pages:0 http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 64 1985 2 0 |
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Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA |
| abstract |
The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. |
| abstractGer |
The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. |
| abstract_unstemmed |
The growth of crown-gall cells cultured in vitro (Nicotiana tabacum L. cv. White Burley and Parthenocissus tricuspidata cv. Veitchii) is inhibited by alstonine (BG-8), a plant alkaloid, the anti-cancer effect of which has previously been demonstrated on animals and plants. The growth of normal cells is only slightly affected. The inhibitory effect of BG-8 on crown-gall cells is antagonized by indole-3-acetic acid (IAA) added to the culture medium. Kinetin associated with IAA does not prevent this inhibitory effect. BG-8 present in the culture medium containing the two types of hormones seems to modify the later hormonal requirement of Parthenocissus crown-gall tissues.BG-8 exhibits high binding affinity for crown-gall DNA and, therefore, strongly inhibits its in vitro synthesis. The alkaloid has practically no effect on DNA from healthy cells. The inhibition by BG-8 is dependent on the level of DNA strand separation and on the origin and nature of the tissues (crown-gall DNA is more destabilized than healthy DNA; DNA from habituated tissues is intermediate). IAA and kinetin have opposite effects on the in vitro strand separation of the DNAs from crown-gall cells and, consequently, antagonistic effects on DNA replication (IAA stimulates and kinetin inhibits). It is possible to establish a close relationship between in situ development of crown-gall tissues of the two species studied (in the presence or absence of BG-8 or cell-growth factors), in vitro DNA synthesis and DNA strand separation. |
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| title_short |
Growth inhibition of crown-gall tissues in relation to the structure and activity of DNA |
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http://dx.doi.org/10.1111/j.1399-3054.1985.tb02332.x |
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| author2 |
Roussaux, J. Cunha, M. I. Aaron-da Beljanski, M. |
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Roussaux, J. Cunha, M. I. Aaron-da Beljanski, M. |
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10.1111/j.1399-3054.1985.tb02332.x |
| up_date |
2024-07-05T21:20:20.764Z |
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| score |
7.40059 |