Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells
Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold in...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
ITO, AKIRA [verfasserIn] TANAKA, CHIKAKO [verfasserIn] TAKEUCHI, TAKUJI [verfasserIn] |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1991 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Periodontology 2000 - Oxford [u.a.] : Wiley-Blackwell, 1993, 4(1991), 5/6, Seite 0 |
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volume:4 ; year:1991 ; number:5/6 ; pages:0 |
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| DOI / URN: |
10.1111/j.1600-0749.1991.tb00448.x |
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| 520 | |a Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. | ||
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10.1111/j.1600-0749.1991.tb00448.x doi (DE-627)NLEJ241159164 DE-627 ger DE-627 rakwb ITO, AKIRA verfasserin aut Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Steroid hormones TANAKA, CHIKAKO verfasserin aut TAKEUCHI, TAKUJI verfasserin aut MISHIMAI, YUTAKA oth In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 4(1991), 5/6, Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:4 year:1991 number:5/6 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1991.tb00448.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1991 5/6 0 |
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10.1111/j.1600-0749.1991.tb00448.x doi (DE-627)NLEJ241159164 DE-627 ger DE-627 rakwb ITO, AKIRA verfasserin aut Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Steroid hormones TANAKA, CHIKAKO verfasserin aut TAKEUCHI, TAKUJI verfasserin aut MISHIMAI, YUTAKA oth In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 4(1991), 5/6, Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:4 year:1991 number:5/6 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1991.tb00448.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1991 5/6 0 |
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10.1111/j.1600-0749.1991.tb00448.x doi (DE-627)NLEJ241159164 DE-627 ger DE-627 rakwb ITO, AKIRA verfasserin aut Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Steroid hormones TANAKA, CHIKAKO verfasserin aut TAKEUCHI, TAKUJI verfasserin aut MISHIMAI, YUTAKA oth In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 4(1991), 5/6, Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:4 year:1991 number:5/6 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1991.tb00448.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1991 5/6 0 |
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10.1111/j.1600-0749.1991.tb00448.x doi (DE-627)NLEJ241159164 DE-627 ger DE-627 rakwb ITO, AKIRA verfasserin aut Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Steroid hormones TANAKA, CHIKAKO verfasserin aut TAKEUCHI, TAKUJI verfasserin aut MISHIMAI, YUTAKA oth In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 4(1991), 5/6, Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:4 year:1991 number:5/6 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1991.tb00448.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1991 5/6 0 |
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10.1111/j.1600-0749.1991.tb00448.x doi (DE-627)NLEJ241159164 DE-627 ger DE-627 rakwb ITO, AKIRA verfasserin aut Glucocorticoid Stimulates Melanogenesis and Tyrosinase Gene Expression in B16 Melanoma Cells Oxford, UK Blackwell Publishing Ltd 1991 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Steroid hormones TANAKA, CHIKAKO verfasserin aut TAKEUCHI, TAKUJI verfasserin aut MISHIMAI, YUTAKA oth In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 4(1991), 5/6, Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:4 year:1991 number:5/6 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1991.tb00448.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1991 5/6 0 |
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| abstract |
Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. |
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Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. |
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Effects of dexamethasone on melanogenesis and tyrosinase mRNA levels were determined in B16/F10 melanoma cells. Melanin content of B16 cells increased in a dosedependent manner by the addition of dexamethasone to the culture medium. After 72 hr exposure, dexamethasone (10−6 M) produced a 2.4-fold increase in melanin content. Northern blot analysis revealed that tyrosinase mRNA level also increased by the addition of dexamethasone to the culture medium. After 24 hr exposure, dexamethasone (10−6 M) caused a 1.8-fold increase in tyrosinase mRNA levels. A tumor promoter, 12-O-tetradecanoyl phorbol-13-acetate (TPA) decreased tyrosinase mRNA level at 30 nM concentration. Dexamethasone antagonized this TPA mediated decrease in tyrosinase mRNA. It is suggested that glucocorticoids are involved in the regulation of tyrosinase activity at the transcriptional level. |
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7.399913 |