Genetic Regulation of Melanocyte Differentiation
Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to th...
Ausführliche Beschreibung
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| Autor*in: |
TAKEUCHI, TAKUJI [verfasserIn] YAMAMOTO, HIROAKI [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1988 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Periodontology 2000 - Oxford [u.a.] : Wiley-Blackwell, 1993, 1(1988), Seite 0 |
| Übergeordnetes Werk: |
volume:1 ; year:1988 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1600-0749.1988.tb00792.x |
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| 520 | |a Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. | ||
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10.1111/j.1600-0749.1988.tb00792.x doi (DE-627)NLEJ24116169X DE-627 ger DE-627 rakwb TAKEUCHI, TAKUJI verfasserin aut Genetic Regulation of Melanocyte Differentiation Oxford, UK Blackwell Publishing Ltd 1988 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Regulation YAMAMOTO, HIROAKI verfasserin aut In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 1(1988), Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:1 year:1988 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1988.tb00792.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 1 1988 0 |
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10.1111/j.1600-0749.1988.tb00792.x doi (DE-627)NLEJ24116169X DE-627 ger DE-627 rakwb TAKEUCHI, TAKUJI verfasserin aut Genetic Regulation of Melanocyte Differentiation Oxford, UK Blackwell Publishing Ltd 1988 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Regulation YAMAMOTO, HIROAKI verfasserin aut In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 1(1988), Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:1 year:1988 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1988.tb00792.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 1 1988 0 |
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10.1111/j.1600-0749.1988.tb00792.x doi (DE-627)NLEJ24116169X DE-627 ger DE-627 rakwb TAKEUCHI, TAKUJI verfasserin aut Genetic Regulation of Melanocyte Differentiation Oxford, UK Blackwell Publishing Ltd 1988 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Regulation YAMAMOTO, HIROAKI verfasserin aut In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 1(1988), Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:1 year:1988 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1988.tb00792.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 1 1988 0 |
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10.1111/j.1600-0749.1988.tb00792.x doi (DE-627)NLEJ24116169X DE-627 ger DE-627 rakwb TAKEUCHI, TAKUJI verfasserin aut Genetic Regulation of Melanocyte Differentiation Oxford, UK Blackwell Publishing Ltd 1988 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Regulation YAMAMOTO, HIROAKI verfasserin aut In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 1(1988), Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:1 year:1988 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1988.tb00792.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 1 1988 0 |
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10.1111/j.1600-0749.1988.tb00792.x doi (DE-627)NLEJ24116169X DE-627 ger DE-627 rakwb TAKEUCHI, TAKUJI verfasserin aut Genetic Regulation of Melanocyte Differentiation Oxford, UK Blackwell Publishing Ltd 1988 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Regulation YAMAMOTO, HIROAKI verfasserin aut In Periodontology 2000 Oxford [u.a.] : Wiley-Blackwell, 1993 1(1988), Seite 0 Online-Ressource (DE-627)NLEJ243925956 (DE-600)2027098-7 1600-0757 nnns volume:1 year:1988 pages:0 http://dx.doi.org/10.1111/j.1600-0749.1988.tb00792.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 1 1988 0 |
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Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. |
| abstractGer |
Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. |
| abstract_unstemmed |
Melanocytes originate from the neural crest in vertebrates and migrate to the body surface where they differentiate into functional cells. Genes involved in melanocyte differentiation can be classified into two groups. One of them consists of the functional genes that control proteins specific to the function of the melanocyte. As the representative gene of this category, albino (c) locus in the mouse is considered to control tyrosinase, the key enzyme in melanogenesis. cDNA for mouse tyrosinase has been cloned and sequenced. The cDNA can be used to detect tyrosinase mRNA synthesized during melanocyte differentiation. On the other hand, genes such as brown (b) or pink-eyed dilution (p) have been assumed to control melanosome proteins.The other category consists of genes that regulate the expression of these functional genes directly or indirectly. In the mouse, so-called white-spotting genes and genes of the agouti series are considered to fall into this category. Based on the fact that mutations at the white-spotting loci result in the absence of melanocytes in a particular area of skin, it is assumed that some of these loci control the factors that promote either differentiation or migration of melanoblasts and are candidates for the classic regulator genesGenes at the agouti (a) locus in the mouse determine the type of melanin synthesized in hair follicle melanocytes, that is eumelanin or pheomelanin. An interesting feature of this locus is that the site of gene action is not within the melanocytes but in the cells surrounding them. The results of our study indicate that the gene product of the a-locus interacts with α-MSH at the α-MSH receptor site, regulates the cellular cAMP level via a signal transduction system and, in turn, determines the type of melanin synthesized in the cells. |
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| title_short |
Genetic Regulation of Melanocyte Differentiation |
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