Ontogenic Development of the Suppressed Secondary Response to Native Dextran
The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide an...
Ausführliche Beschreibung
Autor*in: |
WOOD, C. [verfasserIn] FERNANDEZ, C. [verfasserIn] MÖLLER, G. [verfasserIn] |
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E-Artikel |
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Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1982 |
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Online-Ressource |
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Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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Übergeordnetes Werk: |
In: Scandinavian journal of immunology - Oxford [u.a.] : Wiley-Blackwell, 1972, 16(1982), 4, Seite 0 |
Übergeordnetes Werk: |
volume:16 ; year:1982 ; number:4 ; pages:0 |
Links: |
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DOI / URN: |
10.1111/j.1365-3083.1982.tb00725.x |
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520 | |a The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. | ||
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10.1111/j.1365-3083.1982.tb00725.x doi (DE-627)NLEJ241971217 DE-627 ger DE-627 rakwb WOOD, C. verfasserin aut Ontogenic Development of the Suppressed Secondary Response to Native Dextran Oxford, UK Blackwell Publishing Ltd 1982 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| FERNANDEZ, C. verfasserin aut MÖLLER, G. verfasserin aut In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 16(1982), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:16 year:1982 number:4 pages:0 http://dx.doi.org/10.1111/j.1365-3083.1982.tb00725.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 16 1982 4 0 |
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10.1111/j.1365-3083.1982.tb00725.x doi (DE-627)NLEJ241971217 DE-627 ger DE-627 rakwb WOOD, C. verfasserin aut Ontogenic Development of the Suppressed Secondary Response to Native Dextran Oxford, UK Blackwell Publishing Ltd 1982 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| FERNANDEZ, C. verfasserin aut MÖLLER, G. verfasserin aut In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 16(1982), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:16 year:1982 number:4 pages:0 http://dx.doi.org/10.1111/j.1365-3083.1982.tb00725.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 16 1982 4 0 |
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10.1111/j.1365-3083.1982.tb00725.x doi (DE-627)NLEJ241971217 DE-627 ger DE-627 rakwb WOOD, C. verfasserin aut Ontogenic Development of the Suppressed Secondary Response to Native Dextran Oxford, UK Blackwell Publishing Ltd 1982 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| FERNANDEZ, C. verfasserin aut MÖLLER, G. verfasserin aut In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 16(1982), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:16 year:1982 number:4 pages:0 http://dx.doi.org/10.1111/j.1365-3083.1982.tb00725.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 16 1982 4 0 |
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10.1111/j.1365-3083.1982.tb00725.x doi (DE-627)NLEJ241971217 DE-627 ger DE-627 rakwb WOOD, C. verfasserin aut Ontogenic Development of the Suppressed Secondary Response to Native Dextran Oxford, UK Blackwell Publishing Ltd 1982 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| FERNANDEZ, C. verfasserin aut MÖLLER, G. verfasserin aut In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 16(1982), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:16 year:1982 number:4 pages:0 http://dx.doi.org/10.1111/j.1365-3083.1982.tb00725.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 16 1982 4 0 |
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10.1111/j.1365-3083.1982.tb00725.x doi (DE-627)NLEJ241971217 DE-627 ger DE-627 rakwb WOOD, C. verfasserin aut Ontogenic Development of the Suppressed Secondary Response to Native Dextran Oxford, UK Blackwell Publishing Ltd 1982 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| FERNANDEZ, C. verfasserin aut MÖLLER, G. verfasserin aut In Scandinavian journal of immunology Oxford [u.a.] : Wiley-Blackwell, 1972 16(1982), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392724X (DE-600)2020954-X 1365-3083 nnns volume:16 year:1982 number:4 pages:0 http://dx.doi.org/10.1111/j.1365-3083.1982.tb00725.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 16 1982 4 0 |
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abstract |
The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. |
abstractGer |
The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. |
abstract_unstemmed |
The ontogenic development of the plaque-forming cell (PFC) response to the thymus-independent (TI) antigen alpha 1–6 native dextran B512 was studied to determine when the first minimal amounts of anti-dextran antibodies are formed. Substantial antibody responses to certain other TI polysaccharide antigens arise during the first month of life, whereas the development of the response to native dextran has been found to be conspicuously delayed in high-responder mice. Results indicated that CBA mice began to produce minimal amounts of anti-dextran antibodies between 15 and 21 days of age, and the development continued progressively until peak levels were reached at 90 days of age. The alpha 1–6 native dextran system is also one of the few murine models in which endogenous anti-idiotypic antibodies are formed subsequent to anti-dextran production. It has been shown that the anti-idiotypic antibodies are responsible for specific inhibition of secondary PFC responses to dextran. Suppression of the secondary response was used here to ascertain whether the initial low level of anti-dextran antibodies elicited in 15-day-old animals was sufficient to lead to inhibition of the secondary response. The approach confirmed the initiation of anti-dextran production at 15–21 days of age and indicated that the small amount of anti-dextran antibodies produced at this age was sufficient to induce the mechanism leading to suppression of the secondary response. |
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FERNANDEZ, C. MÖLLER, G. |
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FERNANDEZ, C. MÖLLER, G. |
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10.1111/j.1365-3083.1982.tb00725.x |
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