On the Relationship Between Carcinogenicity and Acute Toxicity
Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Metzger, Bernhard [verfasserIn] Crouch, Edmund [verfasserIn] Wilson, Richard [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1989 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Risk analysis - Oxford [u.a.] : Wiley-Blackwell, 1981, 9(1989), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:9 ; year:1989 ; number:2 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1539-6924.1989.tb01237.x |
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| 520 | |a Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. | ||
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10.1111/j.1539-6924.1989.tb01237.x doi (DE-627)NLEJ24200900X DE-627 ger DE-627 rakwb Metzger, Bernhard verfasserin aut On the Relationship Between Carcinogenicity and Acute Toxicity Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Carcinogenicity Crouch, Edmund verfasserin aut Wilson, Richard verfasserin aut In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 9(1989), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:9 year:1989 number:2 pages:0 http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1989 2 0 |
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10.1111/j.1539-6924.1989.tb01237.x doi (DE-627)NLEJ24200900X DE-627 ger DE-627 rakwb Metzger, Bernhard verfasserin aut On the Relationship Between Carcinogenicity and Acute Toxicity Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Carcinogenicity Crouch, Edmund verfasserin aut Wilson, Richard verfasserin aut In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 9(1989), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:9 year:1989 number:2 pages:0 http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1989 2 0 |
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10.1111/j.1539-6924.1989.tb01237.x doi (DE-627)NLEJ24200900X DE-627 ger DE-627 rakwb Metzger, Bernhard verfasserin aut On the Relationship Between Carcinogenicity and Acute Toxicity Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Carcinogenicity Crouch, Edmund verfasserin aut Wilson, Richard verfasserin aut In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 9(1989), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:9 year:1989 number:2 pages:0 http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1989 2 0 |
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10.1111/j.1539-6924.1989.tb01237.x doi (DE-627)NLEJ24200900X DE-627 ger DE-627 rakwb Metzger, Bernhard verfasserin aut On the Relationship Between Carcinogenicity and Acute Toxicity Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Carcinogenicity Crouch, Edmund verfasserin aut Wilson, Richard verfasserin aut In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 9(1989), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:9 year:1989 number:2 pages:0 http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1989 2 0 |
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10.1111/j.1539-6924.1989.tb01237.x doi (DE-627)NLEJ24200900X DE-627 ger DE-627 rakwb Metzger, Bernhard verfasserin aut On the Relationship Between Carcinogenicity and Acute Toxicity Oxford, UK Blackwell Publishing Ltd 1989 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Carcinogenicity Crouch, Edmund verfasserin aut Wilson, Richard verfasserin aut In Risk analysis Oxford [u.a.] : Wiley-Blackwell, 1981 9(1989), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926847 (DE-600)2001458-2 1539-6924 nnns volume:9 year:1989 number:2 pages:0 http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1989 2 0 |
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Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. |
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Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. |
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Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ24200900X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707144919.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1989 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1539-6924.1989.tb01237.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ24200900X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Metzger, Bernhard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">On the Relationship Between Carcinogenicity and Acute Toxicity</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1989</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non-NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Carcinogenicity</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Crouch, Edmund</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Wilson, Richard</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Risk analysis</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1981</subfield><subfield code="g">9(1989), 2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926847</subfield><subfield code="w">(DE-600)2001458-2</subfield><subfield code="x">1539-6924</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:1989</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1539-6924.1989.tb01237.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">1989</subfield><subfield code="e">2</subfield><subfield code="h">0</subfield></datafield></record></collection>
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