Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin
Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study wa...
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| Autor*in: |
Beitner, H. [verfasserIn] |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2003 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: British journal of dermatology - Oxford : Wiley-Blackwell, 1892, 149(2003), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:149 ; year:2003 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-2133.2003.05597.x |
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NLEJ242116124 |
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| 520 | |a Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. | ||
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10.1046/j.1365-2133.2003.05597.x doi (DE-627)NLEJ242116124 DE-627 ger DE-627 rakwb Beitner, H. verfasserin aut Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| α-lipoic acid In British journal of dermatology Oxford : Wiley-Blackwell, 1892 149(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:149 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 149 2003 4 0 |
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10.1046/j.1365-2133.2003.05597.x doi (DE-627)NLEJ242116124 DE-627 ger DE-627 rakwb Beitner, H. verfasserin aut Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| α-lipoic acid In British journal of dermatology Oxford : Wiley-Blackwell, 1892 149(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:149 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 149 2003 4 0 |
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10.1046/j.1365-2133.2003.05597.x doi (DE-627)NLEJ242116124 DE-627 ger DE-627 rakwb Beitner, H. verfasserin aut Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| α-lipoic acid In British journal of dermatology Oxford : Wiley-Blackwell, 1892 149(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:149 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 149 2003 4 0 |
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10.1046/j.1365-2133.2003.05597.x doi (DE-627)NLEJ242116124 DE-627 ger DE-627 rakwb Beitner, H. verfasserin aut Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| α-lipoic acid In British journal of dermatology Oxford : Wiley-Blackwell, 1892 149(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:149 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 149 2003 4 0 |
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10.1046/j.1365-2133.2003.05597.x doi (DE-627)NLEJ242116124 DE-627 ger DE-627 rakwb Beitner, H. verfasserin aut Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| α-lipoic acid In British journal of dermatology Oxford : Wiley-Blackwell, 1892 149(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:149 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 149 2003 4 0 |
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Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">α-lipoic acid</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">British journal of dermatology</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1892</subfield><subfield code="g">149(2003), 4, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ24392786X</subfield><subfield code="w">(DE-600)2004086-6</subfield><subfield code="x">1365-2133</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:149</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1365-2133.2003.05597.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">149</subfield><subfield code="j">2003</subfield><subfield code="e">4</subfield><subfield code="h">0</subfield></datafield></record></collection>
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randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin |
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Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin |
| abstract |
Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. |
| abstractGer |
Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. |
| abstract_unstemmed |
Background α-lipoic acid (LA) or the reduced form dihydrolipoate (DHLA) is a potent scavenger with anti-inflammatory properties. Previous uncontrolled studies with topical treatment with 5% LA-containing creams indicate a beneficial effect on photoageing skin.Objective The purpose of this study was to investigate whether a cream containing 5% LA showed any advantages concerning a number of the criteria associated with ageing of the facial skin, compared with an identical cream lacking LA.Material and methods Thirty-three women, mean age 54·4 years, were included in this controlled study. After randomization half the face was treated twice daily for 12 weeks with the LA cream and the other half with the control cream. The following methods of assessment were used: self-evaluation by the test subjects, clinical evaluation, photographic evaluation and laser profilometry. Profilometry was performed before the start of treatment and at the end.Results All four methods of assessment showed a statistically significant improvement on the LA-treated half of the face. Laser profilometry, the most objective method used, showed an average decrease in skin roughness of 50·8% (44·9–54·0) on the LA-treated side, compared with 40·7% (32·4–48·7) on the placebo-treated half of the face P < 0·001 (Wilcoxon matched pairs test).Conclusions It is indicated that 12 weeks of treatment with a cream containing 5% LA improves clinical characteristics related to photoageing of facial skin. |
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Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5%α-lipoic acid related to photoageing of facial skin |
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