Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions
Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2)...
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| Autor*in: |
Kiszewski, A.E.C. [verfasserIn] Becerril, E. [verfasserIn] Baquera, J. [verfasserIn] |
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E-Artikel |
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Oxford, UK: Blackwell Science Ltd ; 2003 |
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Online-Ressource |
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2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: British journal of dermatology - Oxford : Wiley-Blackwell, 1892, 148(2003), 4, Seite 0 |
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volume:148 ; year:2003 ; number:4 ; pages:0 |
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10.1046/j.1365-2133.2003.05179.x |
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| 520 | |a Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. | ||
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10.1046/j.1365-2133.2003.05179.x doi (DE-627)NLEJ242119050 DE-627 ger DE-627 rakwb Kiszewski, A.E.C. verfasserin aut Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| cyclooxygenase Becerril, E. verfasserin aut Baquera, J. verfasserin aut Ruiz-Maldonado, R. oth HernÁndez Pando, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 148(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:148 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 148 2003 4 0 |
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10.1046/j.1365-2133.2003.05179.x doi (DE-627)NLEJ242119050 DE-627 ger DE-627 rakwb Kiszewski, A.E.C. verfasserin aut Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| cyclooxygenase Becerril, E. verfasserin aut Baquera, J. verfasserin aut Ruiz-Maldonado, R. oth HernÁndez Pando, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 148(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:148 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 148 2003 4 0 |
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10.1046/j.1365-2133.2003.05179.x doi (DE-627)NLEJ242119050 DE-627 ger DE-627 rakwb Kiszewski, A.E.C. verfasserin aut Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| cyclooxygenase Becerril, E. verfasserin aut Baquera, J. verfasserin aut Ruiz-Maldonado, R. oth HernÁndez Pando, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 148(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:148 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 148 2003 4 0 |
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10.1046/j.1365-2133.2003.05179.x doi (DE-627)NLEJ242119050 DE-627 ger DE-627 rakwb Kiszewski, A.E.C. verfasserin aut Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| cyclooxygenase Becerril, E. verfasserin aut Baquera, J. verfasserin aut Ruiz-Maldonado, R. oth HernÁndez Pando, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 148(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:148 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 148 2003 4 0 |
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10.1046/j.1365-2133.2003.05179.x doi (DE-627)NLEJ242119050 DE-627 ger DE-627 rakwb Kiszewski, A.E.C. verfasserin aut Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| cyclooxygenase Becerril, E. verfasserin aut Baquera, J. verfasserin aut Ruiz-Maldonado, R. oth HernÁndez Pando, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 148(2003), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:148 year:2003 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 148 2003 4 0 |
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High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). 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Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions |
| abstract |
Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. |
| abstractGer |
Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. |
| abstract_unstemmed |
Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy. |
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Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions |
| url |
http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x |
| remote_bool |
true |
| author2 |
Becerril, E. Baquera, J. Ruiz-Maldonado, R. HernÁndez Pando, R. |
| author2Str |
Becerril, E. Baquera, J. Ruiz-Maldonado, R. HernÁndez Pando, R. |
| ppnlink |
NLEJ24392786X |
| mediatype_str_mv |
z |
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false |
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false |
| author2_role |
oth oth |
| doi_str |
10.1046/j.1365-2133.2003.05179.x |
| up_date |
2024-07-06T00:54:02.838Z |
| _version_ |
1803789001388195840 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242119050</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506101518.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2003 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1365-2133.2003.05179.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242119050</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Kiszewski, A.E.C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Expression of cyclooxygenase type 2 in lepromatous and tuberculoid leprosy lesions</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">2003</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary Background Leprosy is an infectious disease with two polar forms, tuberculoid leprosy (TL) and lepromatous leprosy (LL), which are dominated by T-helper (Th) 1 and Th2 cells, respectively. High concentrations of prostaglandin E2 produced by the inducible enzyme cyclooxygenase type 2 (COX-2) in LL could inhibit Th1 cytokine production, contributing to T-cell anergy. Objectives To compare the COX-2 expression in LL and TL. Methods Skin biopsies from 40 leprosy patients (LL, n = 20; TL, n = 20) were used to determine by immunohistochemistry and automated morphometry the percentage of COX-2 immunostained cells. Results Most COX-2-positive cells were macrophages; their percentages in the inflammatory infiltrate located in the papillary dermis, reticular dermis and periadnexally were significantly higher in LL than TL (P < 0·001 by Student's t-test). Conclusions The high expression of COX-2 in LL may be related to high prostaglandin production contributing to T-cell anergy.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">cyclooxygenase</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Becerril, E.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Baquera, J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Ruiz-Maldonado, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">HernÁndez Pando, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">British journal of dermatology</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1892</subfield><subfield code="g">148(2003), 4, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ24392786X</subfield><subfield code="w">(DE-600)2004086-6</subfield><subfield code="x">1365-2133</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:148</subfield><subfield code="g">year:2003</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1365-2133.2003.05179.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">148</subfield><subfield code="j">2003</subfield><subfield code="e">4</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.400696 |