Lymphomatoid papulosis with a natural killer-cell phenotype
Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atyp...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Bekkenk, M.W. [verfasserIn] Kluin, P.M. [verfasserIn] Jansen, P.M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2001 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: British journal of dermatology - Oxford : Wiley-Blackwell, 1892, 145(2001), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:145 ; year:2001 ; number:2 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-2133.2001.04324.x |
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| 520 | |a Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. | ||
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10.1046/j.1365-2133.2001.04324.x doi (DE-627)NLEJ242128661 DE-627 ger DE-627 rakwb Bekkenk, M.W. verfasserin aut Lymphomatoid papulosis with a natural killer-cell phenotype Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| CD56 Kluin, P.M. verfasserin aut Jansen, P.M. verfasserin aut Meijer, C.J.L.M. oth Willemze, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 145(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:145 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 145 2001 2 0 |
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10.1046/j.1365-2133.2001.04324.x doi (DE-627)NLEJ242128661 DE-627 ger DE-627 rakwb Bekkenk, M.W. verfasserin aut Lymphomatoid papulosis with a natural killer-cell phenotype Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| CD56 Kluin, P.M. verfasserin aut Jansen, P.M. verfasserin aut Meijer, C.J.L.M. oth Willemze, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 145(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:145 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 145 2001 2 0 |
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10.1046/j.1365-2133.2001.04324.x doi (DE-627)NLEJ242128661 DE-627 ger DE-627 rakwb Bekkenk, M.W. verfasserin aut Lymphomatoid papulosis with a natural killer-cell phenotype Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| CD56 Kluin, P.M. verfasserin aut Jansen, P.M. verfasserin aut Meijer, C.J.L.M. oth Willemze, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 145(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:145 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 145 2001 2 0 |
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10.1046/j.1365-2133.2001.04324.x doi (DE-627)NLEJ242128661 DE-627 ger DE-627 rakwb Bekkenk, M.W. verfasserin aut Lymphomatoid papulosis with a natural killer-cell phenotype Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| CD56 Kluin, P.M. verfasserin aut Jansen, P.M. verfasserin aut Meijer, C.J.L.M. oth Willemze, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 145(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:145 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 145 2001 2 0 |
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10.1046/j.1365-2133.2001.04324.x doi (DE-627)NLEJ242128661 DE-627 ger DE-627 rakwb Bekkenk, M.W. verfasserin aut Lymphomatoid papulosis with a natural killer-cell phenotype Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| CD56 Kluin, P.M. verfasserin aut Jansen, P.M. verfasserin aut Meijer, C.J.L.M. oth Willemze, R. oth In British journal of dermatology Oxford : Wiley-Blackwell, 1892 145(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:145 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 145 2001 2 0 |
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Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. |
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Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. |
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Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242128661</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707150544.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2001 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1365-2133.2001.04324.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242128661</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Bekkenk, M.W.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Lymphomatoid papulosis with a natural killer-cell phenotype</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Lymphomatoid papulosis (LyP) is defined as a recurrent self-healing papulonodular eruption with the histological features of a (CD30+) cutaneous T-cell lymphoma. The atypical cells usually have a CD3+/–, CD4+/–, CD8–, CD30+, CD56– T-cell phenotype. We report an unusual case of LyP, in which the atypical cells expressed a CD3–, CD4–, CD8–, CD30+, CD56+ phenotype. Detailed phenotypic and genotypic analysis confirmed that these cells had a natural killer (NK)-cell phenotype. Lymphomas with an NK-cell phenotype usually have a poor prognosis. However, the waxing and waning of papular lesions for more than 20 years and the excellent response to low-dose oral methotrexate in this patient suggest similar clinical behaviour to LyP cases with a T-cell phenotype.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2001</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2001||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">CD56</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kluin, P.M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jansen, P.M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Meijer, C.J.L.M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Willemze, R.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">British journal of dermatology</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1892</subfield><subfield code="g">145(2001), 2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ24392786X</subfield><subfield code="w">(DE-600)2004086-6</subfield><subfield code="x">1365-2133</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:145</subfield><subfield code="g">year:2001</subfield><subfield code="g">number:2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1365-2133.2001.04324.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">145</subfield><subfield code="j">2001</subfield><subfield code="e">2</subfield><subfield code="h">0</subfield></datafield></record></collection>
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