Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A
Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the mini...
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Gespeichert in:
| Autor*in: |
Snellman, E. [verfasserIn] Rantanen, T. [verfasserIn] |
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2001 |
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Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: British journal of dermatology - Oxford : Wiley-Blackwell, 1892, 144(2001), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:144 ; year:2001 ; number:3 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-2133.2001.04073.x |
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NLEJ242131174 |
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| 520 | |a Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. | ||
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10.1046/j.1365-2133.2001.04073.x doi (DE-627)NLEJ242131174 DE-627 ger DE-627 rakwb Snellman, E. verfasserin aut Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| dose–response relationship Rantanen, T. verfasserin aut In British journal of dermatology Oxford : Wiley-Blackwell, 1892 144(2001), 3, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:144 year:2001 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 144 2001 3 0 |
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10.1046/j.1365-2133.2001.04073.x doi (DE-627)NLEJ242131174 DE-627 ger DE-627 rakwb Snellman, E. verfasserin aut Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| dose–response relationship Rantanen, T. verfasserin aut In British journal of dermatology Oxford : Wiley-Blackwell, 1892 144(2001), 3, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:144 year:2001 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 144 2001 3 0 |
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10.1046/j.1365-2133.2001.04073.x doi (DE-627)NLEJ242131174 DE-627 ger DE-627 rakwb Snellman, E. verfasserin aut Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| dose–response relationship Rantanen, T. verfasserin aut In British journal of dermatology Oxford : Wiley-Blackwell, 1892 144(2001), 3, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:144 year:2001 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 144 2001 3 0 |
| allfieldsGer |
10.1046/j.1365-2133.2001.04073.x doi (DE-627)NLEJ242131174 DE-627 ger DE-627 rakwb Snellman, E. verfasserin aut Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| dose–response relationship Rantanen, T. verfasserin aut In British journal of dermatology Oxford : Wiley-Blackwell, 1892 144(2001), 3, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:144 year:2001 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 144 2001 3 0 |
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10.1046/j.1365-2133.2001.04073.x doi (DE-627)NLEJ242131174 DE-627 ger DE-627 rakwb Snellman, E. verfasserin aut Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A Oxford, UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| dose–response relationship Rantanen, T. verfasserin aut In British journal of dermatology Oxford : Wiley-Blackwell, 1892 144(2001), 3, Seite 0 Online-Ressource (DE-627)NLEJ24392786X (DE-600)2004086-6 1365-2133 nnns volume:144 year:2001 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 144 2001 3 0 |
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However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. 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Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A |
| abstract |
Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. |
| abstractGer |
Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. |
| abstract_unstemmed |
Background Long-term use of topical trimethylpsoralen (TMP) psoralen bath plus ultraviolet A (bath PUVA) is considered safe with regard to the risk of skin cancer. However, the potential for severe phototoxicity limits its use. Objectives To study the effect of dilution of the TMP bath on the minimal phototoxic dose (MPD). Methods Fifteen volunteers participated in the study. The MPD tests were performed for three TMP concentrations: 0·33 mg L−1, 0·1 mg L−1 and 0·033 mg L−1 at 2-week intervals. Geometric UVA dose series increasing by a factor of √2 were used for the testing on the previously unexposed buttock skin. The MPD72 h was assessed at 72 h from the bath. Results For the highest TMP concentration of 0·33 mg L−1, the median MPD72 h was 0·14 J cm−2 (95% confidence interval (CI), 0·10–0·14 J cm−2). For the diluted TMP bath concentration of 0·1 mg L−1, the median MPD72 h increased to 0·29 J cm−2 (95% CI, 0·2–0·41 J cm−2) and for 0·033 mg L−1 to 0·81 J cm−2 (95% CI, 0·57–1·15 J cm−2), respectively. Thus, diluting the labelled concentration of 0·33 mg L−1 1 : 10 increased the median MPD72 h 5·6-fold. Conclusions With regard to the safety and practicality of the TMP bath PUVA, the lower concentrations of TMP may be of clinical importance, and this needs to be validated in future controlled clinical trials. |
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| title_short |
Concentration-dependent phototoxicity in trimethylpsoralen bath psoralen ultraviolet A |
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http://dx.doi.org/10.1046/j.1365-2133.2001.04073.x |
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Rantanen, T. |
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2024-07-06T00:56:54.986Z |
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