Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases
Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine a...
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Oxford, UK: Blackwell Science Ltd ; 2004 |
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Online-Ressource |
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2004 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Alimentary pharmacology & therapeutics - Oxford : Blackwell Science, 1987, 20(2004), 8, Seite 0 |
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volume:20 ; year:2004 ; number:8 ; pages:0 |
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| DOI / URN: |
10.1111/j.1365-2036.2004.02197.x |
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NLEJ242196993 |
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| 520 | |a Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. | ||
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10.1111/j.1365-2036.2004.02197.x doi (DE-627)NLEJ242196993 DE-627 ger DE-627 rakwb Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Weersma, R. K. oth Peters, F. T. M. oth Oostenbrug, L. E. oth Berg, A. P. oth Haastert, M. oth Ploeg, R. J. oth Posthumus, M. D. oth Homan van der Heide, J. J. oth Jansen, P. L. M. oth Dullemen, H. M. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 20(2004), 8, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:20 year:2004 number:8 pages:0 http://dx.doi.org/10.1111/j.1365-2036.2004.02197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 2004 8 0 |
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10.1111/j.1365-2036.2004.02197.x doi (DE-627)NLEJ242196993 DE-627 ger DE-627 rakwb Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Weersma, R. K. oth Peters, F. T. M. oth Oostenbrug, L. E. oth Berg, A. P. oth Haastert, M. oth Ploeg, R. J. oth Posthumus, M. D. oth Homan van der Heide, J. J. oth Jansen, P. L. M. oth Dullemen, H. M. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 20(2004), 8, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:20 year:2004 number:8 pages:0 http://dx.doi.org/10.1111/j.1365-2036.2004.02197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 2004 8 0 |
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10.1111/j.1365-2036.2004.02197.x doi (DE-627)NLEJ242196993 DE-627 ger DE-627 rakwb Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Weersma, R. K. oth Peters, F. T. M. oth Oostenbrug, L. E. oth Berg, A. P. oth Haastert, M. oth Ploeg, R. J. oth Posthumus, M. D. oth Homan van der Heide, J. J. oth Jansen, P. L. M. oth Dullemen, H. M. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 20(2004), 8, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:20 year:2004 number:8 pages:0 http://dx.doi.org/10.1111/j.1365-2036.2004.02197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 2004 8 0 |
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10.1111/j.1365-2036.2004.02197.x doi (DE-627)NLEJ242196993 DE-627 ger DE-627 rakwb Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Weersma, R. K. oth Peters, F. T. M. oth Oostenbrug, L. E. oth Berg, A. P. oth Haastert, M. oth Ploeg, R. J. oth Posthumus, M. D. oth Homan van der Heide, J. J. oth Jansen, P. L. M. oth Dullemen, H. M. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 20(2004), 8, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:20 year:2004 number:8 pages:0 http://dx.doi.org/10.1111/j.1365-2036.2004.02197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 2004 8 0 |
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10.1111/j.1365-2036.2004.02197.x doi (DE-627)NLEJ242196993 DE-627 ger DE-627 rakwb Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Weersma, R. K. oth Peters, F. T. M. oth Oostenbrug, L. E. oth Berg, A. P. oth Haastert, M. oth Ploeg, R. J. oth Posthumus, M. D. oth Homan van der Heide, J. J. oth Jansen, P. L. M. oth Dullemen, H. M. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 20(2004), 8, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:20 year:2004 number:8 pages:0 http://dx.doi.org/10.1111/j.1365-2036.2004.02197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 20 2004 8 0 |
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Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases |
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Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases |
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Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases |
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Alimentary pharmacology & therapeutics |
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2004 |
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10.1111/j.1365-2036.2004.02197.x |
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increased incidence of azathioprine-induced pancreatitis in crohn's disease compared with other diseases |
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Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases |
| abstract |
Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. |
| abstractGer |
Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. |
| abstract_unstemmed |
Background : Azathioprine is widely used in Crohn's disease. A major drawback is the occurrence of side-effects, especially acute pancreatitis. Acute pancreatitis is rarely seen when azathioprine is used for other diseases than Crohn's disease.Aim : To survey side-effects of azathioprine after liver or renal transplantation, for systemic lupus erythematosis, Wegener's granulomatosis, autoimmune hepatitis, rheumatoid arthritis, ulcerative colitis or Crohn's disease.Methods : A computerized search using the term ‘azathioprine’ or ‘imuran’ was performed on the Hospital Information System of the university hospital Groningen, resulting in 1564 patients matching our criteria.Results : Eleven of 224 patients with Crohn's disease experienced acute pancreatitis (4.9%) compared with two of 129 (1.5%) with autoimmune hepatitis, two of 388 (0.5%) after renal transplantation, one of 254 (0.4%) after liver transplantation. Acute pancreatitis was more prevalent in Crohn's disease compared with any other disease. Azathioprine-toxicity necessitating withdrawal occurred significantly (P < 0,05) more in rheumatoid arthritis(78 of 317), ulcerative colitis (20 of 94) and Crohn's disease (52 of 224) compared with systemic lupus erythematosis (five of 73), Wegener's granulomatosis (six of 85), autoimmune hepatitis (eight of 129), after liver transplantation (17 of 254) and after renal transplantation (22 of 388).Conclusions : Acute pancreatitis is strongly associated with Crohn's disease and rarely occurs with other underlying conditions. Overall azathioprine-induced toxicity and the necessity of withdrawal is more common in inflammatory bowel disease and rheumatoid arthritis compared with other diseases. |
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Increased incidence of azathioprine-induced pancreatitis in Crohn's disease compared with other diseases |
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Weersma, R. K. Peters, F. T. M. Oostenbrug, L. E. Berg, A. P. Haastert, M. Ploeg, R. J. Posthumus, M. D. Homan van der Heide, J. J. Jansen, P. L. M. Dullemen, H. M. |
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Weersma, R. K. Peters, F. T. M. Oostenbrug, L. E. Berg, A. P. Haastert, M. Ploeg, R. J. Posthumus, M. D. Homan van der Heide, J. J. Jansen, P. L. M. Dullemen, H. M. |
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