Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus
Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2">...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Annese, V. [verfasserIn] Lombardi, G. [verfasserIn] Frusciante, V. [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Oxford UK: Blackwell Science Ltd. ; 1997 |
|---|
| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Alimentary pharmacology & therapeutics - Oxford : Blackwell Science, 1987, 11(1997), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:11 ; year:1997 ; number:3 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1365-2036.1997.00177.x |
|---|
| Katalog-ID: |
NLEJ242218695 |
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| 520 | |a Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. | ||
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| 700 | 1 | |a Andriulli, A. |4 oth | |
| 700 | 1 | |a Bassotti, G. |4 oth | |
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10.1046/j.1365-2036.1997.00177.x doi (DE-627)NLEJ242218695 DE-627 ger DE-627 rakwb Annese, V. verfasserin aut Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus Oxford UK Blackwell Science Ltd. 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Lombardi, G. verfasserin aut Frusciante, V. verfasserin aut Germani, U. oth Andriulli, A. oth Bassotti, G. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 11(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:11 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2036.1997.00177.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1997 3 0 |
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10.1046/j.1365-2036.1997.00177.x doi (DE-627)NLEJ242218695 DE-627 ger DE-627 rakwb Annese, V. verfasserin aut Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus Oxford UK Blackwell Science Ltd. 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Lombardi, G. verfasserin aut Frusciante, V. verfasserin aut Germani, U. oth Andriulli, A. oth Bassotti, G. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 11(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:11 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2036.1997.00177.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1997 3 0 |
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10.1046/j.1365-2036.1997.00177.x doi (DE-627)NLEJ242218695 DE-627 ger DE-627 rakwb Annese, V. verfasserin aut Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus Oxford UK Blackwell Science Ltd. 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Lombardi, G. verfasserin aut Frusciante, V. verfasserin aut Germani, U. oth Andriulli, A. oth Bassotti, G. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 11(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:11 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2036.1997.00177.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1997 3 0 |
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10.1046/j.1365-2036.1997.00177.x doi (DE-627)NLEJ242218695 DE-627 ger DE-627 rakwb Annese, V. verfasserin aut Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus Oxford UK Blackwell Science Ltd. 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Lombardi, G. verfasserin aut Frusciante, V. verfasserin aut Germani, U. oth Andriulli, A. oth Bassotti, G. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 11(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:11 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2036.1997.00177.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1997 3 0 |
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10.1046/j.1365-2036.1997.00177.x doi (DE-627)NLEJ242218695 DE-627 ger DE-627 rakwb Annese, V. verfasserin aut Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus Oxford UK Blackwell Science Ltd. 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Lombardi, G. verfasserin aut Frusciante, V. verfasserin aut Germani, U. oth Andriulli, A. oth Bassotti, G. oth In Alimentary pharmacology & therapeutics Oxford : Blackwell Science, 1987 11(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926529 (DE-600)2003094-0 1365-2036 nnns volume:11 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2036.1997.00177.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 11 1997 3 0 |
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Annese, V. |
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10.1046/j.1365-2036.1997.00177.x |
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verfasserin |
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cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus |
| title_auth |
Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus |
| abstract |
Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. |
| abstractGer |
Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. |
| abstract_unstemmed |
Erythromycin, a macrolide antibiotic, has been shown to have gastric prokinetic effects and has been proposed as an alternative therapeutic option for diabetic gastroparesis. However, its efficacy has not yet been compared with that of other prokinetic drugs.<section xml:id="abs1-2"><title type="main">Aims:The purpose of the present study was to compare the effects of erythromycin (250 mg 60 min before meals) and cisapride (10 mg 30 min before meals) on gastric emptying of healthy subjects and insulin-dependent diabetics.<section xml:id="abs1-3"><title type="main">Patients and methods:Six type 1 diabetic patients with a previous scintigraphic demonstration of gastroparesis and five healthy subjects were recruited for the study. Gastric emptying was scintigraphically studied by labelling the solid component of a standard test meal. Three scintigraphic studies, spaced at least 3 days apart, were carried out on each subject, basally and after erythromycin or cisapride.<section xml:id="abs1-4"><title type="main">Results:Cisapride significantly accelerated gastric emptying in both the healthy subjects and the diabetic patients without any significant effect on the lag-time, whereas erythromycin in addition to a significant improvement of the overall gastric emptying also showed a pronounced effect on the lag-time in both groups (controls 25 ± 5 vs. 37 ± 8 min, P≤0.04; diabetics 65 ± 11 vs. 112 ± 16 min, P<0.03).<section xml:id="abs1-5"><title type="main">Conclusions:Erythromycin may represent an effective therapeutic alternative to more established forms of treatment in patients with diabetic gastroparesis, especially when other drugs have failed. |
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Cisapride and erythromycin prokinetic effects in gastroparesis due to type 1 (insulin-dependent) diabetes mellitus |
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Lombardi, G. Frusciante, V. Germani, U. Andriulli, A. Bassotti, G. |
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