Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy
Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present s...
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Oxford, UK: Blackwell Publishing Ltd ; 2000 |
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2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Annals of noninvasive electrocardiology - Oxford : Wiley-Blackwell, 1996, 5(2000), 1, Seite 0 |
Übergeordnetes Werk: |
volume:5 ; year:2000 ; number:1 ; pages:0 |
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DOI / URN: |
10.1111/j.1542-474X.2000.tb00247.x |
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NLEJ242236847 |
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520 | |a Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 | ||
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10.1111/j.1542-474X.2000.tb00247.x doi (DE-627)NLEJ242236847 DE-627 ger DE-627 rakwb Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| hypertrophic cardiomyopathy Yamanari, Hiroshi oth Fukushima, Kengo oth Miyaji, Katsusi oth Yamamoto, Mika oth Nagase, Satoshi oth Otsuka, Fuyou Misunaga oth Nakayama, Kazuaki oth Matsubara, Hiromi oth Emori, Tetsuro oth Ohe, Tohru oth In Annals of noninvasive electrocardiology Oxford : Wiley-Blackwell, 1996 5(2000), 1, Seite 0 Online-Ressource (DE-627)NLEJ243925700 (DE-600)2111515-1 1542-474X nnns volume:5 year:2000 number:1 pages:0 http://dx.doi.org/10.1111/j.1542-474X.2000.tb00247.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 2000 1 0 |
spelling |
10.1111/j.1542-474X.2000.tb00247.x doi (DE-627)NLEJ242236847 DE-627 ger DE-627 rakwb Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| hypertrophic cardiomyopathy Yamanari, Hiroshi oth Fukushima, Kengo oth Miyaji, Katsusi oth Yamamoto, Mika oth Nagase, Satoshi oth Otsuka, Fuyou Misunaga oth Nakayama, Kazuaki oth Matsubara, Hiromi oth Emori, Tetsuro oth Ohe, Tohru oth In Annals of noninvasive electrocardiology Oxford : Wiley-Blackwell, 1996 5(2000), 1, Seite 0 Online-Ressource (DE-627)NLEJ243925700 (DE-600)2111515-1 1542-474X nnns volume:5 year:2000 number:1 pages:0 http://dx.doi.org/10.1111/j.1542-474X.2000.tb00247.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 2000 1 0 |
allfields_unstemmed |
10.1111/j.1542-474X.2000.tb00247.x doi (DE-627)NLEJ242236847 DE-627 ger DE-627 rakwb Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| hypertrophic cardiomyopathy Yamanari, Hiroshi oth Fukushima, Kengo oth Miyaji, Katsusi oth Yamamoto, Mika oth Nagase, Satoshi oth Otsuka, Fuyou Misunaga oth Nakayama, Kazuaki oth Matsubara, Hiromi oth Emori, Tetsuro oth Ohe, Tohru oth In Annals of noninvasive electrocardiology Oxford : Wiley-Blackwell, 1996 5(2000), 1, Seite 0 Online-Ressource (DE-627)NLEJ243925700 (DE-600)2111515-1 1542-474X nnns volume:5 year:2000 number:1 pages:0 http://dx.doi.org/10.1111/j.1542-474X.2000.tb00247.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 2000 1 0 |
allfieldsGer |
10.1111/j.1542-474X.2000.tb00247.x doi (DE-627)NLEJ242236847 DE-627 ger DE-627 rakwb Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| hypertrophic cardiomyopathy Yamanari, Hiroshi oth Fukushima, Kengo oth Miyaji, Katsusi oth Yamamoto, Mika oth Nagase, Satoshi oth Otsuka, Fuyou Misunaga oth Nakayama, Kazuaki oth Matsubara, Hiromi oth Emori, Tetsuro oth Ohe, Tohru oth In Annals of noninvasive electrocardiology Oxford : Wiley-Blackwell, 1996 5(2000), 1, Seite 0 Online-Ressource (DE-627)NLEJ243925700 (DE-600)2111515-1 1542-474X nnns volume:5 year:2000 number:1 pages:0 http://dx.doi.org/10.1111/j.1542-474X.2000.tb00247.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 2000 1 0 |
allfieldsSound |
10.1111/j.1542-474X.2000.tb00247.x doi (DE-627)NLEJ242236847 DE-627 ger DE-627 rakwb Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy Oxford, UK Blackwell Publishing Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| hypertrophic cardiomyopathy Yamanari, Hiroshi oth Fukushima, Kengo oth Miyaji, Katsusi oth Yamamoto, Mika oth Nagase, Satoshi oth Otsuka, Fuyou Misunaga oth Nakayama, Kazuaki oth Matsubara, Hiromi oth Emori, Tetsuro oth Ohe, Tohru oth In Annals of noninvasive electrocardiology Oxford : Wiley-Blackwell, 1996 5(2000), 1, Seite 0 Online-Ressource (DE-627)NLEJ243925700 (DE-600)2111515-1 1542-474X nnns volume:5 year:2000 number:1 pages:0 http://dx.doi.org/10.1111/j.1542-474X.2000.tb00247.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 5 2000 1 0 |
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Yamanari, Hiroshi @@oth@@ Fukushima, Kengo @@oth@@ Miyaji, Katsusi @@oth@@ Yamamoto, Mika @@oth@@ Nagase, Satoshi @@oth@@ Otsuka, Fuyou Misunaga @@oth@@ Nakayama, Kazuaki @@oth@@ Matsubara, Hiromi @@oth@@ Emori, Tetsuro @@oth@@ Ohe, Tohru @@oth@@ |
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Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy |
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Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy |
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Annals of noninvasive electrocardiology |
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2000 |
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10.1111/j.1542-474X.2000.tb00247.x |
title_sort |
effects of myocardial perfusion on qt dispersion in patients with hypertrophic cardiomyopathy |
title_auth |
Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy |
abstract |
Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 |
abstractGer |
Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 |
abstract_unstemmed |
Background:In patients with hypertrophic cardiomyopathy (HCM), myocardial ischemia and myocardial fibrosis as well as ventricular tachyarrhythmia are frequently observed. An increase of heterogeneity of repolarization provided the development of ventricular tachyarrhythmia. The aims of the present study are to evaluate the influence of exercise-induced myocardial perfusion abnormalities on QT dispersion and to assess whether QT dispersion was involved in ventricular tachycardia (VT) in patients with HCM. Methods:Thirty-eight patients with HCM and 20 control subjects underwent an exercise stress test, and QT intervals were measured pre-exercise and at 3 minutes after peak exercise. All subjects underwent thallium (TI)-201 stress myocardial imaging, and their TI-201 defect score and exerciseinduced myocardial ischemia were evaluated. Results:Twelve patients (31%) revealed sustained or nonsustained VT. The pre-exercise QTc dispersion (QTcD) was significantly correlated with the Tl-201 defect score (r = 0.61, P < 0.0001). The QTcD at 3 minutes after peak exercise was significantly greater in patients with exerciseinduced myocardial ischemia than without exercise-induced myocardial ischemia (96 ± 36, 72 ± 24 ms1/2, P < 0.03). The QTcD at 3 minutes after peak exercise was significantly greater in patients with VT than without VT (111 ± 23, 64 ± 17 ms1/2, P < 0.0001). Conclusion:It is suggested that the degree of myocardial fibrosis influences the pre-exercise QTcD, and exercise-induced myocardial ischemia precipitates the increase in the QTcD at 3 minutes after peak exercise in patients with HCM. The increased QTcD at 3 minutes after peak exercise may play a role in identifying patients at a potentially higher risk. A.N.E. 2000;5(1):60–67 |
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Effects of Myocardial Perfusion on QT Dispersion in Patients with Hypertrophic Cardiomyopathy |
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Yamanari, Hiroshi Fukushima, Kengo Miyaji, Katsusi Yamamoto, Mika Nagase, Satoshi Otsuka, Fuyou Misunaga Nakayama, Kazuaki Matsubara, Hiromi Emori, Tetsuro Ohe, Tohru |
author2Str |
Yamanari, Hiroshi Fukushima, Kengo Miyaji, Katsusi Yamamoto, Mika Nagase, Satoshi Otsuka, Fuyou Misunaga Nakayama, Kazuaki Matsubara, Hiromi Emori, Tetsuro Ohe, Tohru |
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