Association study of mast cell chymase polymorphisms with atopy
Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced...
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E-Artikel |
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Oxford, UK: Munksgaard International Publishers ; 2005 |
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Online-Ressource |
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2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Allergy - Oxford : Blackwell Munksgaard, 1978, 60(2005), 10, Seite 0 |
| Übergeordnetes Werk: |
volume:60 ; year:2005 ; number:10 ; pages:0 |
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| DOI / URN: |
10.1111/j.1398-9995.2005.00879.x |
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NLEJ242288235 |
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| 520 | |a Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. | ||
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| 700 | 1 | |a Fischer, G. |4 oth | |
| 700 | 1 | |a Holle, R. |4 oth | |
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| 700 | 1 | |a Schäfer, T. |4 oth | |
| 700 | 1 | |a Jakob, T. |4 oth | |
| 700 | 1 | |a Ollert, M. |4 oth | |
| 700 | 1 | |a Behrendt, H. |4 oth | |
| 700 | 1 | |a Wichmann, H. E. |4 oth | |
| 700 | 1 | |a Ring, J. |4 oth | |
| 700 | 1 | |a Illig, T. |4 oth | |
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10.1111/j.1398-9995.2005.00879.x doi (DE-627)NLEJ242288235 DE-627 ger DE-627 rakwb Association study of mast cell chymase polymorphisms with atopy Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| association Weidinger, S. oth Rümmler, L. oth Klopp, N. oth Wagenpfeil, S. oth Baurecht, H. J. oth Fischer, G. oth Holle, R. oth Gauger, A. oth Schäfer, T. oth Jakob, T. oth Ollert, M. oth Behrendt, H. oth Wichmann, H. E. oth Ring, J. oth Illig, T. oth In Allergy Oxford : Blackwell Munksgaard, 1978 60(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:60 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 60 2005 10 0 |
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10.1111/j.1398-9995.2005.00879.x doi (DE-627)NLEJ242288235 DE-627 ger DE-627 rakwb Association study of mast cell chymase polymorphisms with atopy Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| association Weidinger, S. oth Rümmler, L. oth Klopp, N. oth Wagenpfeil, S. oth Baurecht, H. J. oth Fischer, G. oth Holle, R. oth Gauger, A. oth Schäfer, T. oth Jakob, T. oth Ollert, M. oth Behrendt, H. oth Wichmann, H. E. oth Ring, J. oth Illig, T. oth In Allergy Oxford : Blackwell Munksgaard, 1978 60(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:60 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 60 2005 10 0 |
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10.1111/j.1398-9995.2005.00879.x doi (DE-627)NLEJ242288235 DE-627 ger DE-627 rakwb Association study of mast cell chymase polymorphisms with atopy Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| association Weidinger, S. oth Rümmler, L. oth Klopp, N. oth Wagenpfeil, S. oth Baurecht, H. J. oth Fischer, G. oth Holle, R. oth Gauger, A. oth Schäfer, T. oth Jakob, T. oth Ollert, M. oth Behrendt, H. oth Wichmann, H. E. oth Ring, J. oth Illig, T. oth In Allergy Oxford : Blackwell Munksgaard, 1978 60(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:60 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 60 2005 10 0 |
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10.1111/j.1398-9995.2005.00879.x doi (DE-627)NLEJ242288235 DE-627 ger DE-627 rakwb Association study of mast cell chymase polymorphisms with atopy Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| association Weidinger, S. oth Rümmler, L. oth Klopp, N. oth Wagenpfeil, S. oth Baurecht, H. J. oth Fischer, G. oth Holle, R. oth Gauger, A. oth Schäfer, T. oth Jakob, T. oth Ollert, M. oth Behrendt, H. oth Wichmann, H. E. oth Ring, J. oth Illig, T. oth In Allergy Oxford : Blackwell Munksgaard, 1978 60(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:60 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 60 2005 10 0 |
| allfieldsSound |
10.1111/j.1398-9995.2005.00879.x doi (DE-627)NLEJ242288235 DE-627 ger DE-627 rakwb Association study of mast cell chymase polymorphisms with atopy Oxford, UK Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| association Weidinger, S. oth Rümmler, L. oth Klopp, N. oth Wagenpfeil, S. oth Baurecht, H. J. oth Fischer, G. oth Holle, R. oth Gauger, A. oth Schäfer, T. oth Jakob, T. oth Ollert, M. oth Behrendt, H. oth Wichmann, H. E. oth Ring, J. oth Illig, T. oth In Allergy Oxford : Blackwell Munksgaard, 1978 60(2005), 10, Seite 0 Online-Ressource (DE-627)NLEJ243926979 (DE-600)2003114-2 1398-9995 nnns volume:60 year:2005 number:10 pages:0 http://dx.doi.org/10.1111/j.1398-9995.2005.00879.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 60 2005 10 0 |
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Association study of mast cell chymase polymorphisms with atopy |
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Association study of mast cell chymase polymorphisms with atopy |
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Allergy |
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10.1111/j.1398-9995.2005.00879.x |
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association study of mast cell chymase polymorphisms with atopy |
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Association study of mast cell chymase polymorphisms with atopy |
| abstract |
Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. |
| abstractGer |
Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. |
| abstract_unstemmed |
Background: Atopic disorders are the result of complex interactions between genetic and environmental factors. Associations analyses between the promoter polymorphism rs1800875 in the mast cell chymase gene (CMA1) and atopy-related phenotypes have yielded inconsistent results.Methods: We sequenced the CMA1 locus in 24 unrelated healthy individuals with serum IgE levels <50% percentile and 24 individuals with atopic eczema and serum IgE levels >90% percentile. Seven CMA1 single nucleotide polymorphisms (SNPs) were evaluated for evidence of associations with atopic phenotypes within a large population of German adults (n = 1875). Subjects were phenotyped by standardized questionnaires and interviews, skin prick testing and serum IgE measurements. Genotyping was performed using MALDI-TOF MS (Matrix-Assisted Laser Desorption Ionization–Time of Flight mass spectrometry).Results: Promoter polymorphism rs1800875 was significantly associated with atopic eczema. No associations between any other single SNP and atopic phenotypes could be detected. Haplotype reconstruction revealed four of 128 possible haplotypes reaching estimated frequencies of 3% or more. Two of these haplotypes showed a borderline-significant association with atopic eczema, which did not remain significant after correction for multiple testing.Conclusions: Results confirm previous observations of a significant association between the CMA1 promoter polymorphism rs1800875 and atopic eczema, but not with serum IgE levels, and support the hypothesis that CMA1 serves as candidate gene for atopic eczema. |
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Association study of mast cell chymase polymorphisms with atopy |
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Weidinger, S. Rümmler, L. Klopp, N. Wagenpfeil, S. Baurecht, H. J. Fischer, G. Holle, R. Gauger, A. Schäfer, T. Jakob, T. Ollert, M. Behrendt, H. Wichmann, H. E. Ring, J. Illig, T. |
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Weidinger, S. Rümmler, L. Klopp, N. Wagenpfeil, S. Baurecht, H. J. Fischer, G. Holle, R. Gauger, A. Schäfer, T. Jakob, T. Ollert, M. Behrendt, H. Wichmann, H. E. Ring, J. Illig, T. |
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