Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction
The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ward, Roberta J. [verfasserIn] Mccradden, John [verfasserIn] Tipton, Keith [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1998 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Addiction biology - Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996, 3(1998), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:3 ; year:1998 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1080/13556219872010 |
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| 520 | |a The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. | ||
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10.1080/13556219872010 doi (DE-627)NLEJ242364535 DE-627 ger DE-627 rakwb Ward, Roberta J. verfasserin aut Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Mccradden, John verfasserin aut Tipton, Keith verfasserin aut Sherwood, Roy oth Keating, James oth Peters, Timothy J. oth Witte, Philippe oth In Addiction biology Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 3(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925751 (DE-600)1495537-4 1369-1600 nnns volume:3 year:1998 number:4 pages:0 http://dx.doi.org/10.1080/13556219872010 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1998 4 0 |
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10.1080/13556219872010 doi (DE-627)NLEJ242364535 DE-627 ger DE-627 rakwb Ward, Roberta J. verfasserin aut Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Mccradden, John verfasserin aut Tipton, Keith verfasserin aut Sherwood, Roy oth Keating, James oth Peters, Timothy J. oth Witte, Philippe oth In Addiction biology Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 3(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925751 (DE-600)1495537-4 1369-1600 nnns volume:3 year:1998 number:4 pages:0 http://dx.doi.org/10.1080/13556219872010 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1998 4 0 |
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10.1080/13556219872010 doi (DE-627)NLEJ242364535 DE-627 ger DE-627 rakwb Ward, Roberta J. verfasserin aut Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Mccradden, John verfasserin aut Tipton, Keith verfasserin aut Sherwood, Roy oth Keating, James oth Peters, Timothy J. oth Witte, Philippe oth In Addiction biology Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 3(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925751 (DE-600)1495537-4 1369-1600 nnns volume:3 year:1998 number:4 pages:0 http://dx.doi.org/10.1080/13556219872010 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1998 4 0 |
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10.1080/13556219872010 doi (DE-627)NLEJ242364535 DE-627 ger DE-627 rakwb Ward, Roberta J. verfasserin aut Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Mccradden, John verfasserin aut Tipton, Keith verfasserin aut Sherwood, Roy oth Keating, James oth Peters, Timothy J. oth Witte, Philippe oth In Addiction biology Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 3(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925751 (DE-600)1495537-4 1369-1600 nnns volume:3 year:1998 number:4 pages:0 http://dx.doi.org/10.1080/13556219872010 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1998 4 0 |
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10.1080/13556219872010 doi (DE-627)NLEJ242364535 DE-627 ger DE-627 rakwb Ward, Roberta J. verfasserin aut Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Mccradden, John verfasserin aut Tipton, Keith verfasserin aut Sherwood, Roy oth Keating, James oth Peters, Timothy J. oth Witte, Philippe oth In Addiction biology Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996 3(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925751 (DE-600)1495537-4 1369-1600 nnns volume:3 year:1998 number:4 pages:0 http://dx.doi.org/10.1080/13556219872010 text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 3 1998 4 0 |
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The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. |
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The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. |
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The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242364535</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707153956.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1998 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1080/13556219872010</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242364535</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ward, Roberta J.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Biochemical and genetic studies of Caucasian subjects with ethanol-induced flushing reaction</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The prevalence of ethanol-induced flushing was investigated in three different Caucasian student populations, namely Irish, Belgian and English. Approximately 45% of all female subjects reported a flushing reaction, while 33%, 17% and 9%, respectively, of male students reported this reaction. There was a high familial incidence of flushing in all groups, suggesting that a specific gene defect might be involved. Our previous investigations had inferred normal ALDH2 in such affected individuals, but low activities of erythrocyte ALDH1.1 Since the principal role of this cytosolic enzyme may be in the metabolism of biogenic amines, serotonin levels in platelet-rich plasma and urinary adrenaline, noradrenaline and dopamine were assayed in affected individuals after an oral ethanol challenge. No consistent pattern was evident for any of these parameters in any of the subjects at the time intervals investigated. Genotyping for ADH31 and ADH32 showed a higher frequency for ADH31, 58%, than ADH32, 42%. This is comparable to the Caucasian controls and to our previously published data.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mccradden, John</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Tipton, Keith</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Sherwood, Roy</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Keating, James</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Peters, Timothy J.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Witte, Philippe</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Addiction biology</subfield><subfield code="d">Hoboken, NJ [u.a.] : Wiley-Blackwell, 1996</subfield><subfield code="g">3(1998), 4, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925751</subfield><subfield code="w">(DE-600)1495537-4</subfield><subfield code="x">1369-1600</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:3</subfield><subfield code="g">year:1998</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1080/13556219872010</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">3</subfield><subfield code="j">1998</subfield><subfield code="e">4</subfield><subfield code="h">0</subfield></datafield></record></collection>
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