Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis
Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the prese...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Yamazaki, Kazuhisa [verfasserIn] Tabeta, Kouichi [verfasserIn] Nakajima, Takako [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Copenhagen: Munksgaard International Publishers ; 2001 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Journal of clinical periodontology - Oxford [u.a.] : Wiley-Blackwell, 1974, 28(2001), 9, Seite 0 |
| Übergeordnetes Werk: |
volume:28 ; year:2001 ; number:9 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1034/j.1600-051x.2001.028009828.x |
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NLEJ242370411 |
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| 520 | |a Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. | ||
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10.1034/j.1600-051x.2001.028009828.x doi (DE-627)NLEJ242370411 DE-627 ger DE-627 rakwb Yamazaki, Kazuhisa verfasserin aut Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis Copenhagen Munksgaard International Publishers 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| IL-10 Tabeta, Kouichi verfasserin aut Nakajima, Takako verfasserin aut Ohsawa, Yutaka oth Ueki, Kaoru oth Itoh, Harue oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:28 year:2001 number:9 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2001.028009828.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 9 0 |
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10.1034/j.1600-051x.2001.028009828.x doi (DE-627)NLEJ242370411 DE-627 ger DE-627 rakwb Yamazaki, Kazuhisa verfasserin aut Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis Copenhagen Munksgaard International Publishers 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| IL-10 Tabeta, Kouichi verfasserin aut Nakajima, Takako verfasserin aut Ohsawa, Yutaka oth Ueki, Kaoru oth Itoh, Harue oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:28 year:2001 number:9 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2001.028009828.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 9 0 |
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10.1034/j.1600-051x.2001.028009828.x doi (DE-627)NLEJ242370411 DE-627 ger DE-627 rakwb Yamazaki, Kazuhisa verfasserin aut Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis Copenhagen Munksgaard International Publishers 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| IL-10 Tabeta, Kouichi verfasserin aut Nakajima, Takako verfasserin aut Ohsawa, Yutaka oth Ueki, Kaoru oth Itoh, Harue oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:28 year:2001 number:9 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2001.028009828.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 9 0 |
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10.1034/j.1600-051x.2001.028009828.x doi (DE-627)NLEJ242370411 DE-627 ger DE-627 rakwb Yamazaki, Kazuhisa verfasserin aut Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis Copenhagen Munksgaard International Publishers 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| IL-10 Tabeta, Kouichi verfasserin aut Nakajima, Takako verfasserin aut Ohsawa, Yutaka oth Ueki, Kaoru oth Itoh, Harue oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:28 year:2001 number:9 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2001.028009828.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 9 0 |
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10.1034/j.1600-051x.2001.028009828.x doi (DE-627)NLEJ242370411 DE-627 ger DE-627 rakwb Yamazaki, Kazuhisa verfasserin aut Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis Copenhagen Munksgaard International Publishers 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| IL-10 Tabeta, Kouichi verfasserin aut Nakajima, Takako verfasserin aut Ohsawa, Yutaka oth Ueki, Kaoru oth Itoh, Harue oth Yoshie, Hiromasa oth In Journal of clinical periodontology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 9, Seite 0 Online-Ressource (DE-627)NLEJ243927142 (DE-600)2026349-1 1600-051X nnns volume:28 year:2001 number:9 pages:0 http://dx.doi.org/10.1034/j.1600-051x.2001.028009828.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 9 0 |
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Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis |
| abstract |
Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. |
| abstractGer |
Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. |
| abstract_unstemmed |
Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. We found no significant difference in allele or haplotype frequencies between patients and controls.Conclusions: IL-10 production may be regulated within the complex cytokine network in chronic inflammatory periodontal disease, rather than the gene polymorphisms. |
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Tabeta, Kouichi Nakajima, Takako Ohsawa, Yutaka Ueki, Kaoru Itoh, Harue Yoshie, Hiromasa |
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Tabeta, Kouichi Nakajima, Takako Ohsawa, Yutaka Ueki, Kaoru Itoh, Harue Yoshie, Hiromasa |
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10.1034/j.1600-051x.2001.028009828.x |
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2024-07-06T01:44:51.545Z |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242370411</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506103745.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2001 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1034/j.1600-051x.2001.028009828.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242370411</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Yamazaki, Kazuhisa</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Interleukin-10 gene promoter polymorphism in Japanese patients with adult and early-onset periodontitis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Copenhagen</subfield><subfield code="b">Munksgaard International Publishers</subfield><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background: IL-10 is an anti-inflammatory cytokine, which may modulate disease expression in chronic inflammatory periodontal disease. 3 dimorphic polymorphisms within the IL-10 gene promoter have recently been identified and appear to influence regulation of its expression.Aim: The aim of the present study was to investigate whether the promoter polymorphisms are associated with adult periodontitis (AP) and generalized early-onset periodontitis (G-EOP).Methods: Genomic DNA was obtained from 34 AP patients, 18 G-EOP patients and 52 controls. The promoter region between −506 and −1140 was amplified by polymerase chain reaction, and polymorphisms were detected by nucleotide sequencing.Results: The haplotype frequencies in Japanese were quite different from those of Caucasian and were even slightly different from those of southern Chinese with systemic lupus erythematosus. 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