Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice
Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Vestergaard, Christian [verfasserIn] Deleuran, Mette [verfasserIn] Gesser, Borbala [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK; Malden, USA: Munksgaard International Publishers ; 2004 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2004 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Experimental dermatology - Oxford : Wiley-Blackwell, 1992, 13(2004), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:13 ; year:2004 ; number:4 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.0906-6705.2004.00149.x |
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NLEJ242382886 |
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| 245 | 1 | 0 | |a Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice |
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| 520 | |a Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. | ||
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10.1111/j.0906-6705.2004.00149.x doi (DE-627)NLEJ242382886 DE-627 ger DE-627 rakwb Vestergaard, Christian verfasserin aut Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice Oxford, UK; Malden, USA Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| TARC/CCL17 Deleuran, Mette verfasserin aut Gesser, Borbala verfasserin aut Larsen, Christian Grønhøj oth In Experimental dermatology Oxford : Wiley-Blackwell, 1992 13(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926081 (DE-600)2026228-0 1600-0625 nnns volume:13 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 13 2004 4 0 |
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10.1111/j.0906-6705.2004.00149.x doi (DE-627)NLEJ242382886 DE-627 ger DE-627 rakwb Vestergaard, Christian verfasserin aut Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice Oxford, UK; Malden, USA Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| TARC/CCL17 Deleuran, Mette verfasserin aut Gesser, Borbala verfasserin aut Larsen, Christian Grønhøj oth In Experimental dermatology Oxford : Wiley-Blackwell, 1992 13(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926081 (DE-600)2026228-0 1600-0625 nnns volume:13 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 13 2004 4 0 |
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10.1111/j.0906-6705.2004.00149.x doi (DE-627)NLEJ242382886 DE-627 ger DE-627 rakwb Vestergaard, Christian verfasserin aut Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice Oxford, UK; Malden, USA Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| TARC/CCL17 Deleuran, Mette verfasserin aut Gesser, Borbala verfasserin aut Larsen, Christian Grønhøj oth In Experimental dermatology Oxford : Wiley-Blackwell, 1992 13(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926081 (DE-600)2026228-0 1600-0625 nnns volume:13 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 13 2004 4 0 |
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10.1111/j.0906-6705.2004.00149.x doi (DE-627)NLEJ242382886 DE-627 ger DE-627 rakwb Vestergaard, Christian verfasserin aut Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice Oxford, UK; Malden, USA Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| TARC/CCL17 Deleuran, Mette verfasserin aut Gesser, Borbala verfasserin aut Larsen, Christian Grønhøj oth In Experimental dermatology Oxford : Wiley-Blackwell, 1992 13(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926081 (DE-600)2026228-0 1600-0625 nnns volume:13 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 13 2004 4 0 |
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10.1111/j.0906-6705.2004.00149.x doi (DE-627)NLEJ242382886 DE-627 ger DE-627 rakwb Vestergaard, Christian verfasserin aut Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice Oxford, UK; Malden, USA Munksgaard International Publishers 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| TARC/CCL17 Deleuran, Mette verfasserin aut Gesser, Borbala verfasserin aut Larsen, Christian Grønhøj oth In Experimental dermatology Oxford : Wiley-Blackwell, 1992 13(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926081 (DE-600)2026228-0 1600-0625 nnns volume:13 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 13 2004 4 0 |
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Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice |
| abstract |
Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. |
| abstractGer |
Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. |
| abstract_unstemmed |
Abstract: TARC/CCL17 (thymus- and activation-regulated chemokine) is a CC chemokine, which binds to the CC chemokine receptor-4 (CCR4) known to be distinctively expressed on Th2 lymphocytes. In atopic dermatitis (AD), the skin is invaded by Th2 lymphocytes in the acute phase. TARC/CCL17 is produced by the keratinocytes in AD lesions, and CCR4 is overexpressed on CLA+ (cutaneous lymphocyte-associated antigen) lymphocytes in the skin and blood. We, therefore, hypothesized that TARC/CCL17 is pivotal in mediating a Th2-dominated inflammation in the skin. To examine this, we injected BALB/c mice with murine TARC/CCL17 in concentrations ranging from 0.1 µg/ml to 10 µg/ml and examined the skin after 48 h. This revealed that TARC/CCL17 induces lymphocytic infiltration of the skin by CD4+ lymphocytes in a dose-dependent manner with a maximum response at 1 µg/ml. Additionally, TARC/CCL17 induced interleukin-4 mRNA but not interferon-γ mRNA expression in the skin, suggesting that the lymphocytes invading the skin are Th2 cells. Additionally, TARC/CCL17 induced its own production in the keratinocytes along with cutaneous T-cell-attracting chemokine (CTACK/CCL27) mRNA. We, therefore, conclude that TARC/CCL17 induces a Th2-dominated inflammatory reaction when injected into the skin. |
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| title_short |
Thymus- and activation-regulated chemokine (TARC/CCL17) induces a Th2-dominated inflammatory reaction on intradermal injection in mice |
| url |
http://dx.doi.org/10.1111/j.0906-6705.2004.00149.x |
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| author2 |
Deleuran, Mette Gesser, Borbala Larsen, Christian Grønhøj |
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Deleuran, Mette Gesser, Borbala Larsen, Christian Grønhøj |
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| doi_str |
10.1111/j.0906-6705.2004.00149.x |
| up_date |
2024-07-06T01:47:30.310Z |
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