Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increa...
Ausführliche Beschreibung
Autor*in: |
Ishikawa, Nobue [verfasserIn] Takemura, Motohide [verfasserIn] Koyama, Yutaka [verfasserIn] |
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E-Artikel |
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Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
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Online-Ressource |
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Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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Übergeordnetes Werk: |
In: European journal of neuroscience - Oxford [u.a.] : Blackwell, 1989, 9(1997), 5, Seite 0 |
Übergeordnetes Werk: |
volume:9 ; year:1997 ; number:5 ; pages:0 |
Links: |
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DOI / URN: |
10.1111/j.1460-9568.1997.tb01440.x |
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NLEJ242405541 |
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520 | |a The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. | ||
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10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
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10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
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10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
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10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
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10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
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Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
abstract |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
abstractGer |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
abstract_unstemmed |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
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title_short |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
url |
http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x |
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author2 |
Takemura, Motohide Koyama, Yutaka Shigenaga, Yoshio Okada, Toshikazu Baba, Akemichi |
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Takemura, Motohide Koyama, Yutaka Shigenaga, Yoshio Okada, Toshikazu Baba, Akemichi |
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doi_str |
10.1111/j.1460-9568.1997.tb01440.x |
up_date |
2024-07-06T01:51:51.027Z |
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7.3981476 |