Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increa...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Ishikawa, Nobue [verfasserIn] Takemura, Motohide [verfasserIn] Koyama, Yutaka [verfasserIn] |
|---|
| Format: |
E-Artikel |
|---|
| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
|---|
| Schlagwörter: |
|---|
| Umfang: |
Online-Ressource |
|---|
| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: European journal of neuroscience - Oxford [u.a.] : Blackwell, 1989, 9(1997), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:9 ; year:1997 ; number:5 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1460-9568.1997.tb01440.x |
|---|
| Katalog-ID: |
NLEJ242405541 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLEJ242405541 | ||
| 003 | DE-627 | ||
| 005 | 20210707154601.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 120427s1997 xx |||||o 00| ||und c | ||
| 024 | 7 | |a 10.1111/j.1460-9568.1997.tb01440.x |2 doi | |
| 035 | |a (DE-627)NLEJ242405541 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 100 | 1 | |a Ishikawa, Nobue |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| 264 | 1 | |a Oxford, UK |b Blackwell Publishing Ltd |c 1997 | |
| 300 | |a Online-Ressource | ||
| 336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
| 337 | |a nicht spezifiziert |b z |2 rdamedia | ||
| 338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
| 520 | |a The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. | ||
| 533 | |d 2006 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2006|||||||||| | ||
| 650 | 4 | |a Ala | |
| 700 | 1 | |a Takemura, Motohide |e verfasserin |4 aut | |
| 700 | 1 | |a Koyama, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Shigenaga, Yoshio |4 oth | |
| 700 | 1 | |a Okada, Toshikazu |4 oth | |
| 700 | 1 | |a Baba, Akemichi |4 oth | |
| 773 | 0 | 8 | |i In |t European journal of neuroscience |d Oxford [u.a.] : Blackwell, 1989 |g 9(1997), 5, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243926383 |w (DE-600)2005178-5 |x 1460-9568 |7 nnns |
| 773 | 1 | 8 | |g volume:9 |g year:1997 |g number:5 |g pages:0 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
| 912 | |a GBV_USEFLAG_U | ||
| 912 | |a ZDB-1-DJB | ||
| 912 | |a GBV_NL_ARTICLE | ||
| 951 | |a AR | ||
| 952 | |d 9 |j 1997 |e 5 |h 0 | ||
| author_variant |
n i ni m t mt y k yk |
|---|---|
| matchkey_str |
article:14609568:1997----::nohlnpooehatvtooatoyeirtesra |
| hierarchy_sort_str |
1997 |
| publishDate |
1997 |
| allfields |
10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
| spelling |
10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
| allfields_unstemmed |
10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
| allfieldsGer |
10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
| allfieldsSound |
10.1111/j.1460-9568.1997.tb01440.x doi (DE-627)NLEJ242405541 DE-627 ger DE-627 rakwb Ishikawa, Nobue verfasserin aut Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Ala Takemura, Motohide verfasserin aut Koyama, Yutaka verfasserin aut Shigenaga, Yoshio oth Okada, Toshikazu oth Baba, Akemichi oth In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 9(1997), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:9 year:1997 number:5 pages:0 http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 1997 5 0 |
| source |
In European journal of neuroscience 9(1997), 5, Seite 0 volume:9 year:1997 number:5 pages:0 |
| sourceStr |
In European journal of neuroscience 9(1997), 5, Seite 0 volume:9 year:1997 number:5 pages:0 |
| format_phy_str_mv |
Article |
| institution |
findex.gbv.de |
| topic_facet |
Ala |
| isfreeaccess_bool |
false |
| container_title |
European journal of neuroscience |
| authorswithroles_txt_mv |
Ishikawa, Nobue @@aut@@ Takemura, Motohide @@aut@@ Koyama, Yutaka @@aut@@ Shigenaga, Yoshio @@oth@@ Okada, Toshikazu @@oth@@ Baba, Akemichi @@oth@@ |
| publishDateDaySort_date |
1997-01-01T00:00:00Z |
| hierarchy_top_id |
NLEJ243926383 |
| id |
NLEJ242405541 |
| fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242405541</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707154601.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1997 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1460-9568.1997.tb01440.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242405541</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ishikawa, Nobue</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ala</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takemura, Motohide</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koyama, Yutaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shigenaga, Yoshio</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Okada, Toshikazu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Baba, Akemichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">European journal of neuroscience</subfield><subfield code="d">Oxford [u.a.] : Blackwell, 1989</subfield><subfield code="g">9(1997), 5, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926383</subfield><subfield code="w">(DE-600)2005178-5</subfield><subfield code="x">1460-9568</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:1997</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">1997</subfield><subfield code="e">5</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
Ishikawa, Nobue |
| spellingShingle |
Ishikawa, Nobue misc Ala Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| authorStr |
Ishikawa, Nobue |
| ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243926383 |
| format |
electronic Article |
| delete_txt_mv |
keep |
| author_role |
aut aut aut |
| collection |
NL |
| publishPlace |
Oxford, UK |
| remote_str |
true |
| illustrated |
Not Illustrated |
| issn |
1460-9568 |
| topic_title |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors Ala |
| publisher |
Blackwell Publishing Ltd |
| publisherStr |
Blackwell Publishing Ltd |
| topic |
misc Ala |
| topic_unstemmed |
misc Ala |
| topic_browse |
misc Ala |
| format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
| format_main_str_mv |
Text Zeitschrift/Artikel |
| carriertype_str_mv |
zu |
| author2_variant |
y s ys t o to a b ab |
| hierarchy_parent_title |
European journal of neuroscience |
| hierarchy_parent_id |
NLEJ243926383 |
| hierarchy_top_title |
European journal of neuroscience |
| isfreeaccess_txt |
false |
| familylinks_str_mv |
(DE-627)NLEJ243926383 (DE-600)2005178-5 |
| title |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| ctrlnum |
(DE-627)NLEJ242405541 |
| title_full |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| author_sort |
Ishikawa, Nobue |
| journal |
European journal of neuroscience |
| journalStr |
European journal of neuroscience |
| isOA_bool |
false |
| recordtype |
marc |
| publishDateSort |
1997 |
| contenttype_str_mv |
zzz |
| container_start_page |
0 |
| author_browse |
Ishikawa, Nobue Takemura, Motohide Koyama, Yutaka |
| container_volume |
9 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
Ishikawa, Nobue |
| doi_str_mv |
10.1111/j.1460-9568.1997.tb01440.x |
| author2-role |
verfasserin |
| title_sort |
endothelins promote the activation of astrocytes in rat neostriatum through etb receptors |
| title_auth |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| abstract |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
| abstractGer |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
| abstract_unstemmed |
The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes. |
| collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
| container_issue |
5 |
| title_short |
Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors |
| url |
http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x |
| remote_bool |
true |
| author2 |
Takemura, Motohide Koyama, Yutaka Shigenaga, Yoshio Okada, Toshikazu Baba, Akemichi |
| author2Str |
Takemura, Motohide Koyama, Yutaka Shigenaga, Yoshio Okada, Toshikazu Baba, Akemichi |
| ppnlink |
NLEJ243926383 |
| mediatype_str_mv |
z |
| isOA_txt |
false |
| hochschulschrift_bool |
false |
| author2_role |
oth oth oth |
| doi_str |
10.1111/j.1460-9568.1997.tb01440.x |
| up_date |
2024-07-06T01:51:51.027Z |
| _version_ |
1803792638051090432 |
| fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242405541</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707154601.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1997 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1460-9568.1997.tb01440.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242405541</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Ishikawa, Nobue</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Endothelins Promote the Activation of Astrocytes in Rat Neostriatum through ETB Receptors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">1997</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The effects of endothelin (ET)-3 and an ETB receptor agonist on astrocytic activation in rat caudate putamen were examined by an immunohistochemical staining of glial fibrillary acidic protein (GFAP), a marker of reactive astrocytes. A single injection of 40 pmol ET-3 into rat caudate putamen increased the number of GFAP positive cells compared to that in the contralateral saline-injected side. Ala1,3,11,15-ET-1 (40 pmol), an ETB receptor agonist, also increased the number of striatal GFAP positive cells. The increases in GFAP positive cells were maximum (about 150% of the control side) in 1–2 weeks after injections of the ETs, and then reduced in 4 weeks. A continuous infusion of BQ788, an ETB receptor antagonist (23 nmol/day), into the lateral ventricle of the cerebrum antagonized the effect of Ala1,3,11,15-ET-1, while 80788 also reduced the number of GFAP positive cells in saline-injected caudate putamen. Intrastriatal injection of 40 pmol Ala1,3,11,15-ET-1 did not affect the number of cells stained by B4 isolectin from Griffonia simplicifolia, which labels activated microglia/macrophages. Intraperitoneal administration of 5 mg/kg per day chloroquine and 0.2 mg/kg per day colchicine did not affect the action of Ala1,3,11,15-ET-1. These results suggest that activation of ETB receptors is involved in the induction of reactive astrocytes.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Ala</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takemura, Motohide</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Koyama, Yutaka</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Shigenaga, Yoshio</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Okada, Toshikazu</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Baba, Akemichi</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">European journal of neuroscience</subfield><subfield code="d">Oxford [u.a.] : Blackwell, 1989</subfield><subfield code="g">9(1997), 5, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926383</subfield><subfield code="w">(DE-600)2005178-5</subfield><subfield code="x">1460-9568</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:9</subfield><subfield code="g">year:1997</subfield><subfield code="g">number:5</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1460-9568.1997.tb01440.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">9</subfield><subfield code="j">1997</subfield><subfield code="e">5</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
| score |
7.3981476 |