Presynaptic inhibition by muscimol through GABAB receptors
The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the ampli...
Ausführliche Beschreibung
Autor*in: |
Yamauchi, Tatsuhito [verfasserIn] Hori, Tetsuya [verfasserIn] Takahashi, Tomoyuki [verfasserIn] |
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Format: |
E-Artikel |
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Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2000 |
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Schlagwörter: |
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Umfang: |
Online-Ressource |
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Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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Übergeordnetes Werk: |
In: European journal of neuroscience - Oxford [u.a.] : Blackwell, 1989, 12(2000), 9, Seite 0 |
Übergeordnetes Werk: |
volume:12 ; year:2000 ; number:9 ; pages:0 |
Links: |
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DOI / URN: |
10.1046/j.1460-9568.2000.00248.x |
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NLEJ242438644 |
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10.1046/j.1460-9568.2000.00248.x doi (DE-627)NLEJ242438644 DE-627 ger DE-627 rakwb Yamauchi, Tatsuhito verfasserin aut Presynaptic inhibition by muscimol through GABAB receptors Oxford, UK Blackwell Science Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calyx of Held Hori, Tetsuya verfasserin aut Takahashi, Tomoyuki verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 12(2000), 9, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:12 year:2000 number:9 pages:0 http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2000 9 0 |
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10.1046/j.1460-9568.2000.00248.x doi (DE-627)NLEJ242438644 DE-627 ger DE-627 rakwb Yamauchi, Tatsuhito verfasserin aut Presynaptic inhibition by muscimol through GABAB receptors Oxford, UK Blackwell Science Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calyx of Held Hori, Tetsuya verfasserin aut Takahashi, Tomoyuki verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 12(2000), 9, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:12 year:2000 number:9 pages:0 http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2000 9 0 |
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10.1046/j.1460-9568.2000.00248.x doi (DE-627)NLEJ242438644 DE-627 ger DE-627 rakwb Yamauchi, Tatsuhito verfasserin aut Presynaptic inhibition by muscimol through GABAB receptors Oxford, UK Blackwell Science Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calyx of Held Hori, Tetsuya verfasserin aut Takahashi, Tomoyuki verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 12(2000), 9, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:12 year:2000 number:9 pages:0 http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2000 9 0 |
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10.1046/j.1460-9568.2000.00248.x doi (DE-627)NLEJ242438644 DE-627 ger DE-627 rakwb Yamauchi, Tatsuhito verfasserin aut Presynaptic inhibition by muscimol through GABAB receptors Oxford, UK Blackwell Science Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calyx of Held Hori, Tetsuya verfasserin aut Takahashi, Tomoyuki verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 12(2000), 9, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:12 year:2000 number:9 pages:0 http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2000 9 0 |
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10.1046/j.1460-9568.2000.00248.x doi (DE-627)NLEJ242438644 DE-627 ger DE-627 rakwb Yamauchi, Tatsuhito verfasserin aut Presynaptic inhibition by muscimol through GABAB receptors Oxford, UK Blackwell Science Ltd 2000 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calyx of Held Hori, Tetsuya verfasserin aut Takahashi, Tomoyuki verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 12(2000), 9, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:12 year:2000 number:9 pages:0 http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 12 2000 9 0 |
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The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. |
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The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. |
abstract_unstemmed |
The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242438644</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707155112.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2000 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1460-9568.2000.00248.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242438644</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Yamauchi, Tatsuhito</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Presynaptic inhibition by muscimol through GABAB receptors</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">2000</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">The γ-aminobutyric acid type A (GABAA) receptor agonist muscimol is widely used as a tool for reducing neuronal activities particularly in experiments in vivo. At the synapse formed by the calyx of Held in the rat brainstem slice, the GABAA receptor agonist muscimol (> 10 μm) attenuated the amplitude of excitatory post synaptic currents (EPSCs) accompanied by an increase in the coefficient of variation of EPSCs, suggesting its presynaptic inhibitory effect. This muscimol effect was not affected by bicuculline but occluded the presynaptic inhibitory effect of the GABAB receptor agonist baclofen and was abolished by the type B GABA (GABAB) receptor-specific antagonist (+)-5,5-dimethyl-2-morpholineacetic acid (SCH 50911; 20 μm). We conclude that muscimol activates presynaptic GABAB receptors thereby attenuating synaptic transmission.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2001</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2001||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">calyx of Held</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hori, Tetsuya</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Takahashi, Tomoyuki</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">European journal of neuroscience</subfield><subfield code="d">Oxford [u.a.] : Blackwell, 1989</subfield><subfield code="g">12(2000), 9, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926383</subfield><subfield code="w">(DE-600)2005178-5</subfield><subfield code="x">1460-9568</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:12</subfield><subfield code="g">year:2000</subfield><subfield code="g">number:9</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1460-9568.2000.00248.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">12</subfield><subfield code="j">2000</subfield><subfield code="e">9</subfield><subfield code="h">0</subfield></datafield></record></collection>
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