The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s)
Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent...
Ausführliche Beschreibung
Autor*in: |
Weisenhorn, D. M. Vogt [verfasserIn] Celio, M.R. [verfasserIn] Rickmann, M. [verfasserIn] |
---|
Format: |
E-Artikel |
---|
Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 1998 |
---|
Schlagwörter: |
---|
Umfang: |
Online-Ressource |
---|
Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
---|---|
Übergeordnetes Werk: |
In: European journal of neuroscience - Oxford [u.a.] : Blackwell, 1989, 10(1998), 3, Seite 0 |
Übergeordnetes Werk: |
volume:10 ; year:1998 ; number:3 ; pages:0 |
Links: |
---|
DOI / URN: |
10.1046/j.1460-9568.1998.00120.x |
---|
Katalog-ID: |
NLEJ242449999 |
---|
LEADER | 01000caa a22002652 4500 | ||
---|---|---|---|
001 | NLEJ242449999 | ||
003 | DE-627 | ||
005 | 20210707155300.0 | ||
007 | cr uuu---uuuuu | ||
008 | 120427s1998 xx |||||o 00| ||und c | ||
024 | 7 | |a 10.1046/j.1460-9568.1998.00120.x |2 doi | |
035 | |a (DE-627)NLEJ242449999 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
100 | 1 | |a Weisenhorn, D. M. Vogt |e verfasserin |4 aut | |
245 | 1 | 0 | |a The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
264 | 1 | |a Oxford, UK |b Blackwell Science Ltd |c 1998 | |
300 | |a Online-Ressource | ||
336 | |a nicht spezifiziert |b zzz |2 rdacontent | ||
337 | |a nicht spezifiziert |b z |2 rdamedia | ||
338 | |a nicht spezifiziert |b zu |2 rdacarrier | ||
520 | |a Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. | ||
533 | |d 2001 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2001|||||||||| | ||
650 | 4 | |a calcium-binding proteins | |
700 | 1 | |a Celio, M.R. |e verfasserin |4 aut | |
700 | 1 | |a Rickmann, M. |e verfasserin |4 aut | |
773 | 0 | 8 | |i In |t European journal of neuroscience |d Oxford [u.a.] : Blackwell, 1989 |g 10(1998), 3, Seite 0 |h Online-Ressource |w (DE-627)NLEJ243926383 |w (DE-600)2005178-5 |x 1460-9568 |7 nnns |
773 | 1 | 8 | |g volume:10 |g year:1998 |g number:3 |g pages:0 |
856 | 4 | 0 | |u http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x |q text/html |x Verlag |z Deutschlandweit zugänglich |3 Volltext |
912 | |a GBV_USEFLAG_U | ||
912 | |a ZDB-1-DJB | ||
912 | |a GBV_NL_ARTICLE | ||
951 | |a AR | ||
952 | |d 10 |j 1998 |e 3 |h 0 |
author_variant |
d m v w dmv dmvw m c mc m r mr |
---|---|
matchkey_str |
article:14609568:1998----::hostfavluiepesoiitrernoteapreacred |
hierarchy_sort_str |
1998 |
publishDate |
1998 |
allfields |
10.1046/j.1460-9568.1998.00120.x doi (DE-627)NLEJ242449999 DE-627 ger DE-627 rakwb Weisenhorn, D. M. Vogt verfasserin aut The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calcium-binding proteins Celio, M.R. verfasserin aut Rickmann, M. verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 10(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:10 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 1998 3 0 |
spelling |
10.1046/j.1460-9568.1998.00120.x doi (DE-627)NLEJ242449999 DE-627 ger DE-627 rakwb Weisenhorn, D. M. Vogt verfasserin aut The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calcium-binding proteins Celio, M.R. verfasserin aut Rickmann, M. verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 10(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:10 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 1998 3 0 |
allfields_unstemmed |
10.1046/j.1460-9568.1998.00120.x doi (DE-627)NLEJ242449999 DE-627 ger DE-627 rakwb Weisenhorn, D. M. Vogt verfasserin aut The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calcium-binding proteins Celio, M.R. verfasserin aut Rickmann, M. verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 10(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:10 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 1998 3 0 |
allfieldsGer |
10.1046/j.1460-9568.1998.00120.x doi (DE-627)NLEJ242449999 DE-627 ger DE-627 rakwb Weisenhorn, D. M. Vogt verfasserin aut The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calcium-binding proteins Celio, M.R. verfasserin aut Rickmann, M. verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 10(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:10 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 1998 3 0 |
allfieldsSound |
10.1046/j.1460-9568.1998.00120.x doi (DE-627)NLEJ242449999 DE-627 ger DE-627 rakwb Weisenhorn, D. M. Vogt verfasserin aut The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| calcium-binding proteins Celio, M.R. verfasserin aut Rickmann, M. verfasserin aut In European journal of neuroscience Oxford [u.a.] : Blackwell, 1989 10(1998), 3, Seite 0 Online-Ressource (DE-627)NLEJ243926383 (DE-600)2005178-5 1460-9568 nnns volume:10 year:1998 number:3 pages:0 http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 1998 3 0 |
source |
In European journal of neuroscience 10(1998), 3, Seite 0 volume:10 year:1998 number:3 pages:0 |
sourceStr |
In European journal of neuroscience 10(1998), 3, Seite 0 volume:10 year:1998 number:3 pages:0 |
format_phy_str_mv |
Article |
institution |
findex.gbv.de |
topic_facet |
calcium-binding proteins |
isfreeaccess_bool |
false |
container_title |
European journal of neuroscience |
authorswithroles_txt_mv |
Weisenhorn, D. M. Vogt @@aut@@ Celio, M.R. @@aut@@ Rickmann, M. @@aut@@ |
publishDateDaySort_date |
1998-01-01T00:00:00Z |
hierarchy_top_id |
NLEJ243926383 |
id |
NLEJ242449999 |
fullrecord |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242449999</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707155300.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1998 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1460-9568.1998.00120.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242449999</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weisenhorn, D. M. Vogt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2001</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2001||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">calcium-binding proteins</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Celio, M.R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rickmann, M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">European journal of neuroscience</subfield><subfield code="d">Oxford [u.a.] : Blackwell, 1989</subfield><subfield code="g">10(1998), 3, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926383</subfield><subfield code="w">(DE-600)2005178-5</subfield><subfield code="x">1460-9568</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:1998</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">1998</subfield><subfield code="e">3</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
series2 |
Blackwell Publishing Journal Backfiles 1879-2005 |
author |
Weisenhorn, D. M. Vogt |
spellingShingle |
Weisenhorn, D. M. Vogt misc calcium-binding proteins The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
authorStr |
Weisenhorn, D. M. Vogt |
ppnlink_with_tag_str_mv |
@@773@@(DE-627)NLEJ243926383 |
format |
electronic Article |
delete_txt_mv |
keep |
author_role |
aut aut aut |
collection |
NL |
publishPlace |
Oxford, UK |
remote_str |
true |
illustrated |
Not Illustrated |
issn |
1460-9568 |
topic_title |
The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) calcium-binding proteins |
publisher |
Blackwell Science Ltd |
publisherStr |
Blackwell Science Ltd |
topic |
misc calcium-binding proteins |
topic_unstemmed |
misc calcium-binding proteins |
topic_browse |
misc calcium-binding proteins |
format_facet |
Elektronische Aufsätze Aufsätze Elektronische Ressource |
format_main_str_mv |
Text Zeitschrift/Artikel |
carriertype_str_mv |
zu |
hierarchy_parent_title |
European journal of neuroscience |
hierarchy_parent_id |
NLEJ243926383 |
hierarchy_top_title |
European journal of neuroscience |
isfreeaccess_txt |
false |
familylinks_str_mv |
(DE-627)NLEJ243926383 (DE-600)2005178-5 |
title |
The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
ctrlnum |
(DE-627)NLEJ242449999 |
title_full |
The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
author_sort |
Weisenhorn, D. M. Vogt |
journal |
European journal of neuroscience |
journalStr |
European journal of neuroscience |
isOA_bool |
false |
recordtype |
marc |
publishDateSort |
1998 |
contenttype_str_mv |
zzz |
container_start_page |
0 |
author_browse |
Weisenhorn, D. M. Vogt Celio, M.R. Rickmann, M. |
container_volume |
10 |
physical |
Online-Ressource |
format_se |
Elektronische Aufsätze |
author-letter |
Weisenhorn, D. M. Vogt |
doi_str_mv |
10.1046/j.1460-9568.1998.00120.x |
author2-role |
verfasserin |
title_sort |
the onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
title_auth |
The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
abstract |
Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. |
abstractGer |
Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. |
abstract_unstemmed |
Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required. |
collection_details |
GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE |
container_issue |
3 |
title_short |
The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s) |
url |
http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x |
remote_bool |
true |
author2 |
Celio, M.R. Rickmann, M. |
author2Str |
Celio, M.R. Rickmann, M. |
ppnlink |
NLEJ243926383 |
mediatype_str_mv |
z |
isOA_txt |
false |
hochschulschrift_bool |
false |
doi_str |
10.1046/j.1460-9568.1998.00120.x |
up_date |
2024-07-06T02:03:35.406Z |
_version_ |
1803793376657539073 |
fullrecord_marcxml |
<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242449999</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707155300.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1998 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1460-9568.1998.00120.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242449999</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Weisenhorn, D. M. Vogt</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The onset of parvalbumin-expression in interneurons of the rat parietal cortex depends upon extrinsic factor(s)</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Parvalbumin (PV) belongs to the large family of EF-hand calcium-binding proteins and is an excellent marker for a subpopulation of GABAergic neocortical interneurons. During cortical development, PV first appears on postnatal day (P)8, in the infragranular layers; after P14, it also becomes apparent within the supragranular layers. However, nothing is known about the factors controlling its expression, which could involve functional activity, neuronal connectivity and/or neurotrophic factors. It being difficult to manipulate these parameters in vivo, their role may be more readily assessed in organotypic cultures, which are deprived of their subcortical afferents and efferents, and hence of subcortically derived neurotrophic factors and extrinsic functional activity. We prepared slices of the rat brain on P3, P5, P7 and P9, maintained them in culture for 2–5 weeks, and compared the temporal and spatial distribution pattern of PV-immunoreactivity within these slices with the in vivo situation. We found, first, that during late postnatal in vivo development and ageing, the number of PV-immunoreactive neurons in the parietal cortex decreases significantly, and second, that the expression of PV-immunoreactivity in the parietal cortex was markedly influenced by the phase of postnatal development at which slice cultures were explanted. In those removed on P7 and P9, the number of PV-immunoreactive cells, as well as the temporal and spatial distribution pattern of PV-immunoreactivity corresponded to the in vivo situation, but in explants obtained on P3 or P5, PV-immunoreactivity remained confined to layer V of the cortex, reminiscent of the expression profile manifested at the end of the second postnatal week in vivo. Also, the number of PV-immunoreactive cells in these cultures was significantly lower than in explants at the later stages. Our results indicate that the onset of PV-expression in the parietal cortex depends upon extrinsic cortical factors subsisting prior to P7. Once the production of this protein has been initiated, such influences are no longer required.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2001</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2001||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">calcium-binding proteins</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Celio, M.R.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Rickmann, M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">European journal of neuroscience</subfield><subfield code="d">Oxford [u.a.] : Blackwell, 1989</subfield><subfield code="g">10(1998), 3, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926383</subfield><subfield code="w">(DE-600)2005178-5</subfield><subfield code="x">1460-9568</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:10</subfield><subfield code="g">year:1998</subfield><subfield code="g">number:3</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1460-9568.1998.00120.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">10</subfield><subfield code="j">1998</subfield><subfield code="e">3</subfield><subfield code="h">0</subfield></datafield></record></collection>
|
score |
7.3978004 |