DNA damage and TNFα cytokine production in hairdressers with contact dermatitis
The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and aller...
Ausführliche Beschreibung
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| Autor*in: |
Cavallo, Delia [verfasserIn] Ursini, Cinzia Lucia [verfasserIn] Setini, Andrea [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK; Malden, USA: Munksgaard International Publishers ; 2005 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2005 ; Blackwell Publishing Journal Backfiles 1879-2005 |
|---|---|
| Übergeordnetes Werk: |
In: Contact dermatitis - Oxford [u.a.] : Wiley-Blackwell, 1975, 53(2005), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:53 ; year:2005 ; number:3 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.0105-1873.2005.00672.x |
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NLEJ242524621 |
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| 520 | |a The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. | ||
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10.1111/j.0105-1873.2005.00672.x doi (DE-627)NLEJ242524621 DE-627 ger DE-627 rakwb Cavallo, Delia verfasserin aut DNA damage and TNFα cytokine production in hairdressers with contact dermatitis Oxford, UK; Malden, USA Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| direct-oxidative DNA damage Ursini, Cinzia Lucia verfasserin aut Setini, Andrea verfasserin aut Chianese, Concetta oth Cristaudo, Antonio oth Iavicoli, Sergio oth In Contact dermatitis Oxford [u.a.] : Wiley-Blackwell, 1975 53(2005), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927118 (DE-600)2027120-7 1600-0536 nnns volume:53 year:2005 number:3 pages:0 http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 53 2005 3 0 |
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10.1111/j.0105-1873.2005.00672.x doi (DE-627)NLEJ242524621 DE-627 ger DE-627 rakwb Cavallo, Delia verfasserin aut DNA damage and TNFα cytokine production in hairdressers with contact dermatitis Oxford, UK; Malden, USA Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| direct-oxidative DNA damage Ursini, Cinzia Lucia verfasserin aut Setini, Andrea verfasserin aut Chianese, Concetta oth Cristaudo, Antonio oth Iavicoli, Sergio oth In Contact dermatitis Oxford [u.a.] : Wiley-Blackwell, 1975 53(2005), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927118 (DE-600)2027120-7 1600-0536 nnns volume:53 year:2005 number:3 pages:0 http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 53 2005 3 0 |
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10.1111/j.0105-1873.2005.00672.x doi (DE-627)NLEJ242524621 DE-627 ger DE-627 rakwb Cavallo, Delia verfasserin aut DNA damage and TNFα cytokine production in hairdressers with contact dermatitis Oxford, UK; Malden, USA Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| direct-oxidative DNA damage Ursini, Cinzia Lucia verfasserin aut Setini, Andrea verfasserin aut Chianese, Concetta oth Cristaudo, Antonio oth Iavicoli, Sergio oth In Contact dermatitis Oxford [u.a.] : Wiley-Blackwell, 1975 53(2005), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927118 (DE-600)2027120-7 1600-0536 nnns volume:53 year:2005 number:3 pages:0 http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 53 2005 3 0 |
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10.1111/j.0105-1873.2005.00672.x doi (DE-627)NLEJ242524621 DE-627 ger DE-627 rakwb Cavallo, Delia verfasserin aut DNA damage and TNFα cytokine production in hairdressers with contact dermatitis Oxford, UK; Malden, USA Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| direct-oxidative DNA damage Ursini, Cinzia Lucia verfasserin aut Setini, Andrea verfasserin aut Chianese, Concetta oth Cristaudo, Antonio oth Iavicoli, Sergio oth In Contact dermatitis Oxford [u.a.] : Wiley-Blackwell, 1975 53(2005), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927118 (DE-600)2027120-7 1600-0536 nnns volume:53 year:2005 number:3 pages:0 http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 53 2005 3 0 |
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10.1111/j.0105-1873.2005.00672.x doi (DE-627)NLEJ242524621 DE-627 ger DE-627 rakwb Cavallo, Delia verfasserin aut DNA damage and TNFα cytokine production in hairdressers with contact dermatitis Oxford, UK; Malden, USA Munksgaard International Publishers 2005 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. 2005 Blackwell Publishing Journal Backfiles 1879-2005 |2005|||||||||| direct-oxidative DNA damage Ursini, Cinzia Lucia verfasserin aut Setini, Andrea verfasserin aut Chianese, Concetta oth Cristaudo, Antonio oth Iavicoli, Sergio oth In Contact dermatitis Oxford [u.a.] : Wiley-Blackwell, 1975 53(2005), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927118 (DE-600)2027120-7 1600-0536 nnns volume:53 year:2005 number:3 pages:0 http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 53 2005 3 0 |
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DNA damage and TNFα cytokine production in hairdressers with contact dermatitis |
| abstract |
The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. |
| abstractGer |
The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. |
| abstract_unstemmed |
The present work was undertaken to study in hairdressers exposed to several irritants and allergens (prevalently hair-dyeing) and affected by hand contact dermatitis the possible correlation between exposure and direct-oxidative DNA damage, production of tumour necrosis factor alpha (TNFα) and allergic inflammatory disease. We evaluated in 19 hairdressers with hand contact dermatitis, 14 allergic contact dermatitis (ACD) and 5 irritant contact dermatitis (ICD) and in a selected control group TNFα serum levels by ELISA and direct-oxidative DNA damage by Fpg (formamido-pyrimidine-glycosylase)-modified Comet test on blood. Hairdressers were divided on the basis of number of hair-dyeing carried out weekly into 2 groups: low-exposure (<60 hair-dyeing/week) and high-exposure hairdressers (≥60 hair-dyeing/week) that reflect also the exposure to other allergens and irritants and 2 different tasks (hairdressers and apprentice hairdressers, respectively). Serum levels of TNFα in hairdressers with ACD were significantly higher than controls with a correlation to exposure level. Significant DNA damage in ICD hairdressers with higher exposure as compared to controls was found. These findings suggest that occupational exposure can induce in hairdressers, particularly ICD, DNA damage, increase the TNFa levels particularly in ACD and induce allergic sensitization, suggesting a relationship between direct-oxidative DNA damage, TNFα production and allergic inflammatory disease. |
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| title_short |
DNA damage and TNFα cytokine production in hairdressers with contact dermatitis |
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http://dx.doi.org/10.1111/j.0105-1873.2005.00672.x |
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| author2 |
Ursini, Cinzia Lucia Setini, Andrea Chianese, Concetta Cristaudo, Antonio Iavicoli, Sergio |
| author2Str |
Ursini, Cinzia Lucia Setini, Andrea Chianese, Concetta Cristaudo, Antonio Iavicoli, Sergio |
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| doi_str |
10.1111/j.0105-1873.2005.00672.x |
| up_date |
2024-07-06T02:16:54.409Z |
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