Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves
1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Topçu, T?gba [verfasserIn] Gülpınar, Mehmet Ali [verfasserIn] I·şman, Çăgla A [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Melbourne, Australia: Blackwell Science Pty ; 2002 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2002 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 29(2002), 1/2, Seite 0 |
| Übergeordnetes Werk: |
volume:29 ; year:2002 ; number:1/2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1440-1681.2002.03602.x |
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| Katalog-ID: |
NLEJ242572642 |
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| 520 | |a 1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. | ||
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10.1046/j.1440-1681.2002.03602.x doi (DE-627)NLEJ242572642 DE-627 ger DE-627 rakwb Topçu, T?gba verfasserin aut Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves Melbourne, Australia Blackwell Science Pty 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| capsaicin Gülpınar, Mehmet Ali verfasserin aut I·şman, Çăgla A verfasserin aut Ye˘gen, Berrak Ç oth Ye˘gen, Cumhur oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 29(2002), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:29 year:2002 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2002.03602.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 2002 1/2 0 |
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10.1046/j.1440-1681.2002.03602.x doi (DE-627)NLEJ242572642 DE-627 ger DE-627 rakwb Topçu, T?gba verfasserin aut Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves Melbourne, Australia Blackwell Science Pty 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| capsaicin Gülpınar, Mehmet Ali verfasserin aut I·şman, Çăgla A verfasserin aut Ye˘gen, Berrak Ç oth Ye˘gen, Cumhur oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 29(2002), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:29 year:2002 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2002.03602.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 2002 1/2 0 |
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10.1046/j.1440-1681.2002.03602.x doi (DE-627)NLEJ242572642 DE-627 ger DE-627 rakwb Topçu, T?gba verfasserin aut Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves Melbourne, Australia Blackwell Science Pty 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| capsaicin Gülpınar, Mehmet Ali verfasserin aut I·şman, Çăgla A verfasserin aut Ye˘gen, Berrak Ç oth Ye˘gen, Cumhur oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 29(2002), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:29 year:2002 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2002.03602.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 2002 1/2 0 |
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10.1046/j.1440-1681.2002.03602.x doi (DE-627)NLEJ242572642 DE-627 ger DE-627 rakwb Topçu, T?gba verfasserin aut Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves Melbourne, Australia Blackwell Science Pty 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. 2002 Blackwell Publishing Journal Backfiles 1879-2005 |2002|||||||||| capsaicin Gülpınar, Mehmet Ali verfasserin aut I·şman, Çăgla A verfasserin aut Ye˘gen, Berrak Ç oth Ye˘gen, Cumhur oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 29(2002), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:29 year:2002 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2002.03602.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 2002 1/2 0 |
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Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves |
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Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves |
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Topçu, T?gba |
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Clinical and experimental pharmacology and physiology |
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2002 |
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Topçu, T?gba Gülpınar, Mehmet Ali I·şman, Çăgla A |
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Topçu, T?gba |
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10.1046/j.1440-1681.2002.03602.x |
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verfasserin |
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enterogastric brake in rats with segmental bowel resection: role of capsaicin-sensitive nerves |
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Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves |
| abstract |
1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. |
| abstractGer |
1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. |
| abstract_unstemmed |
1. Unabsorbed nutrients in the distal gut inhibit upper gastrointestinal motility.2. The aim of the present study was to investigate changes in gastric motility following segmental resections and to evaluate the role of capsaicin-sensitive afferent neurons that may be responsible for these changes.3. Wistar albino rats of both sexes (200–250 g) were used. Under aseptic conditions and anaesthesia (100 mg/kg ketamine), a baby-feeding tube was placed distal to the resection in either the ileum or caecum for intraluminal perfusion of saline or 20% lipid. In one group of rats, capsaicin was perfused (0.6%) for afferent denervation. One group of rats underwent jejunal and ileal resections with end-to-end anastomosis of the remaining segments and were cannulated distal to these anastomosis. Ten days after the surgery, the percentage gastric emptying of a solid meal was calculated.4. Intra-ileal (18%) and intracaecal (34%) lipid perfusions delayed gastric emptying compared with groups perfused with saline (54% and 74%, respectively; P < 0.001 and P < 0.01). The delay in gastric emptying by ileal perfusion was significantly greater than that following caecal perfusion (P < 0.05). With both resections, gastric emptying was delayed compared with sham groups (P < 0.05–0.01). Local administration of capsaicin abolished the inhibitory effect of lipid on gastric emptying in healthy intact rats and in the jejunal-resection group, whereas a partial reversal was seen in the ileal-resection group.5. In conclusion, the present data demonstrate that in both healthy intact rat groups and in short bowel groups, capsaicin-sensitive extrinsic neurons participate in ‘brake’ mechanisms of the distal gut. |
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Enterogastric Brake In Rats With Segmental Bowel Resection: Role Of Capsaicin-Sensitive Nerves |
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Gülpınar, Mehmet Ali I·şman, Çăgla A Ye˘gen, Berrak Ç Ye˘gen, Cumhur |
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