Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats
1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –...
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Gespeichert in:
| Autor*in: |
Leckie, Brenda J [verfasserIn] |
|---|
| Format: |
E-Artikel |
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| Erschienen: |
Melbourne, Australia: Blackwell Science Pty ; 2001 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 28(2001), 1/2, Seite 0 |
| Übergeordnetes Werk: |
volume:28 ; year:2001 ; number:1/2 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1440-1681.2001.03397.x |
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| 520 | |a 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. | ||
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10.1046/j.1440-1681.2001.03397.x doi (DE-627)NLEJ242574726 DE-627 ger DE-627 rakwb Leckie, Brenda J verfasserin aut Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats Melbourne, Australia Blackwell Science Pty 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| renin gene polymorphism In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:28 year:2001 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 1/2 0 |
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10.1046/j.1440-1681.2001.03397.x doi (DE-627)NLEJ242574726 DE-627 ger DE-627 rakwb Leckie, Brenda J verfasserin aut Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats Melbourne, Australia Blackwell Science Pty 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| renin gene polymorphism In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:28 year:2001 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 1/2 0 |
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10.1046/j.1440-1681.2001.03397.x doi (DE-627)NLEJ242574726 DE-627 ger DE-627 rakwb Leckie, Brenda J verfasserin aut Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats Melbourne, Australia Blackwell Science Pty 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| renin gene polymorphism In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:28 year:2001 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 1/2 0 |
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10.1046/j.1440-1681.2001.03397.x doi (DE-627)NLEJ242574726 DE-627 ger DE-627 rakwb Leckie, Brenda J verfasserin aut Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats Melbourne, Australia Blackwell Science Pty 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| renin gene polymorphism In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:28 year:2001 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 1/2 0 |
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10.1046/j.1440-1681.2001.03397.x doi (DE-627)NLEJ242574726 DE-627 ger DE-627 rakwb Leckie, Brenda J verfasserin aut Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats Melbourne, Australia Blackwell Science Pty 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| renin gene polymorphism In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 28(2001), 1/2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:28 year:2001 number:1/2 pages:0 http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 28 2001 1/2 0 |
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polymorphisms of the renin gene promoter in spontaneously hypertensive and wistar-kyoto rats |
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Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats |
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1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. |
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1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. |
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1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242574726</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230506143726.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2001 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1440-1681.2001.03397.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242574726</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Leckie, Brenda J</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Polymorphisms Of The Renin Gene Promoter In Spontaneously Hypertensive And Wistar-Kyoto Rats</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Melbourne, Australia</subfield><subfield code="b">Blackwell Science Pty</subfield><subfield code="c">2001</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">1. In the present study, 1.39 kb of the renin gene 5′ region in spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats was amplified by polymerase chain reaction from genomic DNA and sequenced. Consistent differences in the renin gene sequence of SHR and WKY rats were found at positions –725, –727, –979 and –1126/–1129 as numbered from the transcription start site (+1). No polymorphism was specific to hypertensive rats.2. Gel-shift assays were performed using labelled SHR renin promotor DNA and nuclear proteins extracted from rat kidneys. The regions between –1122 and –1139 and between –701 and –797 showed protein binding.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">renin gene polymorphism</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Clinical and experimental pharmacology and physiology</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1974</subfield><subfield code="g">28(2001), 1/2, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243927150</subfield><subfield code="w">(DE-600)2020033-X</subfield><subfield code="x">1440-1681</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:28</subfield><subfield code="g">year:2001</subfield><subfield code="g">number:1/2</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1440-1681.2001.03397.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">28</subfield><subfield code="j">2001</subfield><subfield code="e">1/2</subfield><subfield code="h">0</subfield></datafield></record></collection>
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