MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY
1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tai...
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| Autor*in: |
Mutafova-Yambolieva, Violeta N. [verfasserIn] Westfall, David P. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1998 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 25(1998), 12, Seite 0 |
| Übergeordnetes Werk: |
volume:25 ; year:1998 ; number:12 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1440-1681.1998.tb02176.x |
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| 520 | |a 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. | ||
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10.1111/j.1440-1681.1998.tb02176.x doi (DE-627)NLEJ242580289 DE-627 ger DE-627 rakwb Mutafova-Yambolieva, Violeta N. verfasserin aut MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| adenine purines Westfall, David P. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 25(1998), 12, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:25 year:1998 number:12 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 25 1998 12 0 |
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10.1111/j.1440-1681.1998.tb02176.x doi (DE-627)NLEJ242580289 DE-627 ger DE-627 rakwb Mutafova-Yambolieva, Violeta N. verfasserin aut MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| adenine purines Westfall, David P. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 25(1998), 12, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:25 year:1998 number:12 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 25 1998 12 0 |
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10.1111/j.1440-1681.1998.tb02176.x doi (DE-627)NLEJ242580289 DE-627 ger DE-627 rakwb Mutafova-Yambolieva, Violeta N. verfasserin aut MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| adenine purines Westfall, David P. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 25(1998), 12, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:25 year:1998 number:12 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 25 1998 12 0 |
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10.1111/j.1440-1681.1998.tb02176.x doi (DE-627)NLEJ242580289 DE-627 ger DE-627 rakwb Mutafova-Yambolieva, Violeta N. verfasserin aut MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| adenine purines Westfall, David P. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 25(1998), 12, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:25 year:1998 number:12 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 25 1998 12 0 |
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10.1111/j.1440-1681.1998.tb02176.x doi (DE-627)NLEJ242580289 DE-627 ger DE-627 rakwb Mutafova-Yambolieva, Violeta N. verfasserin aut MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY Oxford, UK Blackwell Publishing Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| adenine purines Westfall, David P. verfasserin aut In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 25(1998), 12, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:25 year:1998 number:12 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 25 1998 12 0 |
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MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY |
| author_sort |
Mutafova-Yambolieva, Violeta N. |
| journal |
Clinical and experimental pharmacology and physiology |
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Clinical and experimental pharmacology and physiology |
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marc |
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1998 |
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zzz |
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0 |
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Mutafova-Yambolieva, Violeta N. Westfall, David P. |
| container_volume |
25 |
| physical |
Online-Ressource |
| format_se |
Elektronische Aufsätze |
| author-letter |
Mutafova-Yambolieva, Violeta N. |
| doi_str_mv |
10.1111/j.1440-1681.1998.tb02176.x |
| author2-role |
verfasserin |
| title_sort |
modulatory effects of type-c natriuretic peptide on sympathetic cotransmission in the rat isolated tail artery |
| title_auth |
MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY |
| abstract |
1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. |
| abstractGer |
1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. |
| abstract_unstemmed |
1. Rat type-C natriuretic peptide (CNP) has been studied for its effects on the neurogenically induced overflow of adenosine 5′-triphosphate (ATP), adenosine 5′-diphosphate (ADP), adenosine 5-monophosphate (AMP), adenosine (ADO) and noradrenaline (NA) in endothelium-free segments of rat isolated tail artery. The overflow of each was evoked by electrical field stimulation (EFS) of 0.5 ms pulses at 8 Hz for 3 min and the amount of ATP, ADP, AMP and ADO was quantified by high-performance liquid chromatography (HPLC)-fluorescent detection, while the amount of NA was quantified by HPLC-electrochemical detection.2. Type-C natriuretic peptide (100 nmol/L) was found to cause a significant reduction of the overflow of all adenine purines and NA. However, at lower concentrations (1 and 10 nmol/L), CNP caused a significant reduction of the overflow of NA but did not change ATP overflow.3. The overflow of ADP, AMP and ADO was significantly reduced by either concentration of CNP, so that the ratio ATP:ADP was diminished from 1:2 in controls to 1:1 after 1 nmol/L CNP and to 1:1.2 after 10 nmol/L CNP.4. The production of inorganic phosphate (Pi) in response to the exogenous application of ATP was significantly reduced by 1,10 or 100 nmol/L CNP.5. Type-C natriuretic peptide exerts neuromodulatory effects on the neurogenically induced release of the cotransmitters ATP and NA in rat tail artery, consisting of an inhibition of the release of both ATP and NA. This effect is accompanied by inhibition of the breakdown of ATP by ecto-ATPases. Either effect results in apparent CNP-induced differential modulation of the overflow of the cotransmitters ATP and NA. |
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12 |
| title_short |
MODULATORY EFFECTS OF TYPE-C NATRIURETIC PEPTIDE ON SYMPATHETIC COTRANSMISSION IN THE RAT ISOLATED TAIL ARTERY |
| url |
http://dx.doi.org/10.1111/j.1440-1681.1998.tb02176.x |
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| author2 |
Westfall, David P. |
| author2Str |
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| up_date |
2024-07-06T02:28:35.510Z |
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