SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS
1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of...
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| Autor*in: |
Wen, Cheng [verfasserIn] Liu, Dennis T. [verfasserIn] Li, Ming [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 24(1997), 9/10, Seite 0 |
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volume:24 ; year:1997 ; number:9/10 ; pages:0 |
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| DOI / URN: |
10.1111/j.1440-1681.1997.tb02120.x |
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| 520 | |a 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. | ||
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10.1111/j.1440-1681.1997.tb02120.x doi (DE-627)NLEJ24258103X DE-627 ger DE-627 rakwb Wen, Cheng verfasserin aut SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| dose-response Liu, Dennis T. verfasserin aut Li, Ming verfasserin aut Michaelis, Jurgen oth Grigg, Geoffrey W. oth Whitworth, Judith A. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 9/10, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:9/10 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb02120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 9/10 0 |
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10.1111/j.1440-1681.1997.tb02120.x doi (DE-627)NLEJ24258103X DE-627 ger DE-627 rakwb Wen, Cheng verfasserin aut SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| dose-response Liu, Dennis T. verfasserin aut Li, Ming verfasserin aut Michaelis, Jurgen oth Grigg, Geoffrey W. oth Whitworth, Judith A. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 9/10, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:9/10 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb02120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 9/10 0 |
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10.1111/j.1440-1681.1997.tb02120.x doi (DE-627)NLEJ24258103X DE-627 ger DE-627 rakwb Wen, Cheng verfasserin aut SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| dose-response Liu, Dennis T. verfasserin aut Li, Ming verfasserin aut Michaelis, Jurgen oth Grigg, Geoffrey W. oth Whitworth, Judith A. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 9/10, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:9/10 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb02120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 9/10 0 |
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10.1111/j.1440-1681.1997.tb02120.x doi (DE-627)NLEJ24258103X DE-627 ger DE-627 rakwb Wen, Cheng verfasserin aut SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| dose-response Liu, Dennis T. verfasserin aut Li, Ming verfasserin aut Michaelis, Jurgen oth Grigg, Geoffrey W. oth Whitworth, Judith A. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 9/10, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:9/10 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb02120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 9/10 0 |
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10.1111/j.1440-1681.1997.tb02120.x doi (DE-627)NLEJ24258103X DE-627 ger DE-627 rakwb Wen, Cheng verfasserin aut SHORT COMMUNICATION HYPOTENSIVE EFFECTS OF PEPTIDE T IN CONSCIOUS RATS Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| dose-response Liu, Dennis T. verfasserin aut Li, Ming verfasserin aut Michaelis, Jurgen oth Grigg, Geoffrey W. oth Whitworth, Judith A. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 9/10, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:9/10 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb02120.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 9/10 0 |
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1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. |
| abstractGer |
1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. |
| abstract_unstemmed |
1. The present study investigated the effects of peptide T on mean arterial blood pressure (MAP) in conscious normotensive Sprague-Dawley (SD) rats, spontaneously hypertensive rats (SHR) and two-kidney one-clip (2K1C) hypertensive rats.2. Peptide T was infused via the left jugular vein at a rate of 1 mg/kg per h in SD, SHR and 2K1C rats and then at doses of 0.1, 0.25, 0.5,1 and 5 mg/kg per h in SHR, with 0.9% saline as a sham control in SHR and 2K1C. Mean arterial pressure was measured directly before, during and after infusion.3. Peptide T (1 mg/kg per h) decreased blood pressure in both SHR (/><0.01) and 2K1C (P<0.05). In normotensive SD rats the fall in MAP approached statistical significance (P = 0.06). The effect of peptide T was not significantly different in normotensive compared with hypertensive rats. Saline infusion had no effect. The blood pressure lowering effect of peptide T appeared to be dose-dependent in SHR. |
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