EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU
1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimula...
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| Autor*in: |
Kohzuki, H. [verfasserIn] Enoki, Y. [verfasserIn] Ohga, Y. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2007 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical and experimental pharmacology and physiology - Oxford [u.a.] : Wiley-Blackwell, 1974, 24(1997), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:24 ; year:1997 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1111/j.1440-1681.1997.tb01805.x |
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| Katalog-ID: |
NLEJ242582184 |
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| 245 | 1 | 0 | |a EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
| 264 | 1 | |a Oxford, UK |b Blackwell Publishing Ltd |c 1997 | |
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| 520 | |a 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. | ||
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| 700 | 1 | |a Ohga, Y. |e verfasserin |4 aut | |
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| 700 | 1 | |a Shimizu, S. |4 oth | |
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| 700 | 1 | |a Kishi, T. |4 oth | |
| 700 | 1 | |a Takaki, M. |4 oth | |
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10.1111/j.1440-1681.1997.tb01805.x doi (DE-627)NLEJ242582184 DE-627 ger DE-627 rakwb Kohzuki, H. verfasserin aut EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| O Enoki, Y. verfasserin aut Ohga, Y. verfasserin aut Sakata, S. oth Shimizu, S. oth Morimoto, T. oth Kishi, T. oth Takaki, M. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:2 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb01805.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 2 0 |
| spelling |
10.1111/j.1440-1681.1997.tb01805.x doi (DE-627)NLEJ242582184 DE-627 ger DE-627 rakwb Kohzuki, H. verfasserin aut EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| O Enoki, Y. verfasserin aut Ohga, Y. verfasserin aut Sakata, S. oth Shimizu, S. oth Morimoto, T. oth Kishi, T. oth Takaki, M. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:2 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb01805.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 2 0 |
| allfields_unstemmed |
10.1111/j.1440-1681.1997.tb01805.x doi (DE-627)NLEJ242582184 DE-627 ger DE-627 rakwb Kohzuki, H. verfasserin aut EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| O Enoki, Y. verfasserin aut Ohga, Y. verfasserin aut Sakata, S. oth Shimizu, S. oth Morimoto, T. oth Kishi, T. oth Takaki, M. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:2 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb01805.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 2 0 |
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10.1111/j.1440-1681.1997.tb01805.x doi (DE-627)NLEJ242582184 DE-627 ger DE-627 rakwb Kohzuki, H. verfasserin aut EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| O Enoki, Y. verfasserin aut Ohga, Y. verfasserin aut Sakata, S. oth Shimizu, S. oth Morimoto, T. oth Kishi, T. oth Takaki, M. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:2 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb01805.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 2 0 |
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10.1111/j.1440-1681.1997.tb01805.x doi (DE-627)NLEJ242582184 DE-627 ger DE-627 rakwb Kohzuki, H. verfasserin aut EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier 1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. 2007 Blackwell Publishing Journal Backfiles 1879-2005 |2007|||||||||| O Enoki, Y. verfasserin aut Ohga, Y. verfasserin aut Sakata, S. oth Shimizu, S. oth Morimoto, T. oth Kishi, T. oth Takaki, M. oth In Clinical and experimental pharmacology and physiology Oxford [u.a.] : Wiley-Blackwell, 1974 24(1997), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927150 (DE-600)2020033-X 1440-1681 nnns volume:24 year:1997 number:2 pages:0 http://dx.doi.org/10.1111/j.1440-1681.1997.tb01805.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 24 1997 2 0 |
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Blackwell Publishing Journal Backfiles 1879-2005 |
| author |
Kohzuki, H. |
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Kohzuki, H. misc O EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
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EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU O |
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EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
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EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
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Kohzuki, H. Enoki, Y. Ohga, Y. |
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Kohzuki, H. |
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effect of blood flow and haematocrit on the relationship between muscle venous po2 and oxygen uptake in dog maximally contracting gastrocnemius in situ |
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EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
| abstract |
1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. |
| abstractGer |
1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. |
| abstract_unstemmed |
1. To clarify the limiting factors for peak V̇o2 (V̇o2peak)> we measured muscle venous Po2 (Pvo2) and V̇o2, peak under various O2 delivery conditions (arterial O2 concentration X flow) via the alteration of blood flow and haematocrit (Hct) in anaesthetized dog gastrocnemius muscle (n= 11) stimulated by 1 Hz isometrically and tetanically.2. Two levels of flow (high and moderate) were maintained by using a pump (ISO and 100 mL/min per 100 g, respectively). Haematocrit was adjusted to 45 and 30% by isovolaemic haemodilution with dextran (MW 40 000).3. The decrease in Hct induced a 31% decrease in O2 delivery (P<0.05), a 9–12% decrease in Pvo2, a 23% decrease in V̇o2, peak(P<0.05) and a 12–14% increase in O2 extraction (V̇o2/O2delivery) at both flow levels. The decrease in flow induced a 24–25% decrease in O2 delivery (P<0.05), a 15–17% decrease in Pvo2 (P<0.05), a 9% decrease in V̇o2,peak (P<0.05) and a 19–22% increase in O2 extraction (P<0.05) at both Hct levels.4. The results suggest that the limiting factor of V̇o2peak, unrelated to O2 diffusion limitation (i.e. the change in the heterogeneity of V̇o2 to O2 delivery ratio among capillaries), due to lowering Hct may be different from that due to lowering blood flow in maximally contracting muscle. |
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EFFECT OF BLOOD FLOW AND HAEMATOCRIT ON THE RELATIONSHIP BETWEEN MUSCLE VENOUS Po2 AND OXYGEN UPTAKE IN DOG MAXIMALLY CONTRACTING GASTROCNEMIUS IN SITU |
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