Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status
Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objec...
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| Autor*in: |
CALVERLEY [verfasserIn] REES [verfasserIn] DOWDESWELL [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford BSL: Blackwell Science Ltd ; 1999 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Clinical & experimental allergy - Oxford : Blackwell Science, 1989, 29(1999), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:29 ; year:1999 ; number:5 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-2222.1999.00515.x |
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NLEJ242619053 |
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| 245 | 1 | 0 | |a Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status |
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| 520 | |a Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). | ||
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10.1046/j.1365-2222.1999.00515.x doi (DE-627)NLEJ242619053 DE-627 ger DE-627 rakwb CALVERLEY verfasserin aut Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status Oxford BSL Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| platinum salt sensitivity REES verfasserin aut DOWDESWELL verfasserin aut In Clinical & experimental allergy Oxford : Blackwell Science, 1989 29(1999), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926391 (DE-600)2004469-0 1365-2222 nnns volume:29 year:1999 number:5 pages:0 http://dx.doi.org/10.1046/j.1365-2222.1999.00515.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 1999 5 0 |
| spelling |
10.1046/j.1365-2222.1999.00515.x doi (DE-627)NLEJ242619053 DE-627 ger DE-627 rakwb CALVERLEY verfasserin aut Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status Oxford BSL Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| platinum salt sensitivity REES verfasserin aut DOWDESWELL verfasserin aut In Clinical & experimental allergy Oxford : Blackwell Science, 1989 29(1999), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926391 (DE-600)2004469-0 1365-2222 nnns volume:29 year:1999 number:5 pages:0 http://dx.doi.org/10.1046/j.1365-2222.1999.00515.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 1999 5 0 |
| allfields_unstemmed |
10.1046/j.1365-2222.1999.00515.x doi (DE-627)NLEJ242619053 DE-627 ger DE-627 rakwb CALVERLEY verfasserin aut Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status Oxford BSL Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| platinum salt sensitivity REES verfasserin aut DOWDESWELL verfasserin aut In Clinical & experimental allergy Oxford : Blackwell Science, 1989 29(1999), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926391 (DE-600)2004469-0 1365-2222 nnns volume:29 year:1999 number:5 pages:0 http://dx.doi.org/10.1046/j.1365-2222.1999.00515.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 1999 5 0 |
| allfieldsGer |
10.1046/j.1365-2222.1999.00515.x doi (DE-627)NLEJ242619053 DE-627 ger DE-627 rakwb CALVERLEY verfasserin aut Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status Oxford BSL Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| platinum salt sensitivity REES verfasserin aut DOWDESWELL verfasserin aut In Clinical & experimental allergy Oxford : Blackwell Science, 1989 29(1999), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926391 (DE-600)2004469-0 1365-2222 nnns volume:29 year:1999 number:5 pages:0 http://dx.doi.org/10.1046/j.1365-2222.1999.00515.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 1999 5 0 |
| allfieldsSound |
10.1046/j.1365-2222.1999.00515.x doi (DE-627)NLEJ242619053 DE-627 ger DE-627 rakwb CALVERLEY verfasserin aut Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status Oxford BSL Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| platinum salt sensitivity REES verfasserin aut DOWDESWELL verfasserin aut In Clinical & experimental allergy Oxford : Blackwell Science, 1989 29(1999), 5, Seite 0 Online-Ressource (DE-627)NLEJ243926391 (DE-600)2004469-0 1365-2222 nnns volume:29 year:1999 number:5 pages:0 http://dx.doi.org/10.1046/j.1365-2222.1999.00515.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 29 1999 5 0 |
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Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. 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1999 |
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CALVERLEY REES DOWDESWELL |
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Elektronische Aufsätze |
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CALVERLEY |
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10.1046/j.1365-2222.1999.00515.x |
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verfasserin |
| title_sort |
allergy to complex salts of platinum in refinery workers: prospective evaluations of ige and phadiatop® status |
| title_auth |
Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status |
| abstract |
Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). |
| abstractGer |
Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). |
| abstract_unstemmed |
Background Experience has shown some variation in the associations between IgE, atopy, and sensitization to platinum salts. Clarification of these associations, and the value of the parameters in predicting and diagnosing sensitization of workers at risk, required prospective investigation. Objectives Evaluation of total IgE and Phadiatop® status to establish baseline values, and changes during employment, predictive or associated with subsequent platinum salt sensitization. Methods A 24-month prospective study, in a South African primary platinum refinery, of a cohort of 78 healthy recruits without evidence of atopy (tested negative to skin prick test with common allergens). Subsequently they were categorized as 22 sensitized (positive skin prick test to platinum salts), 46 not sensitized (negative skin prick test and symptom free), and 10 symptomatic subjects not included in either category. Results (1) Pre-employment: four (18%) of the subsequently sensitized subjects and eight (17%) not sensitized were Phadiatop® positive. Levels of total IgE > 100 kU/L, present in 16 subjects were associated with positive Phadiatop® status and race. (2) During employment: Phadiatop® status converted from negative to positive in more sensitized (12/18) than unsensitized (6/38) subjects (P ≤ 0.0001). Total IgE levels at outcome had increased in more sensitized subjects, and median levels were higher than in unsensitized subjects (17 (77%) vs six (13%), and 92 vs 26 kU/L, P = 0.0015). Multivariate analysis showed the likelihood of an increase in total IgE was nine times greater in subjects sensitized to platinum salts, and five times greater with higher platinum salt exposure. Specific IgE was demonstrated, generally in only one sample of the series, in two sensitized and three unsensitized subjects. Positive responses to skin prick tests with common allergens occurred in five (23%) sensitized and 11 (24%) unsensitized subjects. Conclusion Platinum salt sensitivity was not predicted by pre-employment Phadiatop® or IgE status, but was subsequently associated with conversion to positive Phadiatop® status, and an increase in total IgE (independent of Phadiatop® status). |
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Allergy to complex salts of platinum in refinery workers: prospective evaluations of IgE and Phadiatop® status |
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