Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population
Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene h...
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E-Artikel |
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| Erschienen: |
Melbourne, Australia: Blackwell Science Pty ; 2003 |
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Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: International journal of urology - Oxford [u.a.] : Wiley-Blackwell, 1997, 10(2003), 5, Seite 0 |
| Übergeordnetes Werk: |
volume:10 ; year:2003 ; number:5 ; pages:0 |
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| DOI / URN: |
10.1046/j.1442-2042.2003.00617.x |
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NLEJ242682634 |
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| 520 | |a Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. | ||
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10.1046/j.1442-2042.2003.00617.x doi (DE-627)NLEJ242682634 DE-627 ger DE-627 rakwb Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| family history SUZUKI, KAZUHIRO oth MATSUI, HIROSHI oth OHTAKE, NOBUAKI oth NAKATA, SEIJI oth TAKEI, TOMOYUKI oth KOIKE, HIDEKAZU oth NAKAZATO, HARUKI oth OKUGI, HIRONOBU oth HASUMI, MASARU oth FUKABORI, YOSHITATSU oth KUROKAWA, KOHEI oth YAMANAKA, HIDETOSHI oth In International journal of urology Oxford [u.a.] : Wiley-Blackwell, 1997 10(2003), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925654 (DE-600)2009793-1 1442-2042 nnns volume:10 year:2003 number:5 pages:0 http://dx.doi.org/10.1046/j.1442-2042.2003.00617.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2003 5 0 |
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10.1046/j.1442-2042.2003.00617.x doi (DE-627)NLEJ242682634 DE-627 ger DE-627 rakwb Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| family history SUZUKI, KAZUHIRO oth MATSUI, HIROSHI oth OHTAKE, NOBUAKI oth NAKATA, SEIJI oth TAKEI, TOMOYUKI oth KOIKE, HIDEKAZU oth NAKAZATO, HARUKI oth OKUGI, HIRONOBU oth HASUMI, MASARU oth FUKABORI, YOSHITATSU oth KUROKAWA, KOHEI oth YAMANAKA, HIDETOSHI oth In International journal of urology Oxford [u.a.] : Wiley-Blackwell, 1997 10(2003), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925654 (DE-600)2009793-1 1442-2042 nnns volume:10 year:2003 number:5 pages:0 http://dx.doi.org/10.1046/j.1442-2042.2003.00617.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2003 5 0 |
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10.1046/j.1442-2042.2003.00617.x doi (DE-627)NLEJ242682634 DE-627 ger DE-627 rakwb Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| family history SUZUKI, KAZUHIRO oth MATSUI, HIROSHI oth OHTAKE, NOBUAKI oth NAKATA, SEIJI oth TAKEI, TOMOYUKI oth KOIKE, HIDEKAZU oth NAKAZATO, HARUKI oth OKUGI, HIRONOBU oth HASUMI, MASARU oth FUKABORI, YOSHITATSU oth KUROKAWA, KOHEI oth YAMANAKA, HIDETOSHI oth In International journal of urology Oxford [u.a.] : Wiley-Blackwell, 1997 10(2003), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925654 (DE-600)2009793-1 1442-2042 nnns volume:10 year:2003 number:5 pages:0 http://dx.doi.org/10.1046/j.1442-2042.2003.00617.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2003 5 0 |
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10.1046/j.1442-2042.2003.00617.x doi (DE-627)NLEJ242682634 DE-627 ger DE-627 rakwb Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| family history SUZUKI, KAZUHIRO oth MATSUI, HIROSHI oth OHTAKE, NOBUAKI oth NAKATA, SEIJI oth TAKEI, TOMOYUKI oth KOIKE, HIDEKAZU oth NAKAZATO, HARUKI oth OKUGI, HIRONOBU oth HASUMI, MASARU oth FUKABORI, YOSHITATSU oth KUROKAWA, KOHEI oth YAMANAKA, HIDETOSHI oth In International journal of urology Oxford [u.a.] : Wiley-Blackwell, 1997 10(2003), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925654 (DE-600)2009793-1 1442-2042 nnns volume:10 year:2003 number:5 pages:0 http://dx.doi.org/10.1046/j.1442-2042.2003.00617.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2003 5 0 |
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10.1046/j.1442-2042.2003.00617.x doi (DE-627)NLEJ242682634 DE-627 ger DE-627 rakwb Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population Melbourne, Australia Blackwell Science Pty 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| family history SUZUKI, KAZUHIRO oth MATSUI, HIROSHI oth OHTAKE, NOBUAKI oth NAKATA, SEIJI oth TAKEI, TOMOYUKI oth KOIKE, HIDEKAZU oth NAKAZATO, HARUKI oth OKUGI, HIRONOBU oth HASUMI, MASARU oth FUKABORI, YOSHITATSU oth KUROKAWA, KOHEI oth YAMANAKA, HIDETOSHI oth In International journal of urology Oxford [u.a.] : Wiley-Blackwell, 1997 10(2003), 5, Seite 0 Online-Ressource (DE-627)NLEJ243925654 (DE-600)2009793-1 1442-2042 nnns volume:10 year:2003 number:5 pages:0 http://dx.doi.org/10.1046/j.1442-2042.2003.00617.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 10 2003 5 0 |
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10.1046/j.1442-2042.2003.00617.x |
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vitamin d receptor gene polymorphism in familial prostate cancer in a japanese population |
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Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population |
| abstract |
Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. |
| abstractGer |
Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. |
| abstract_unstemmed |
Aim: Vitamin D acts as an antiproliferative agent against prostate cells. Epidemiological study has shown that a low level of serum vitamin D concentration is a risk factor for prostate cancer. Vitamin D acts via vitamin D receptor (VDR), and an association of genetic polymorphisms of the VDR gene has been reported. In the current study, we examined the association of VDR gene polymorphisms with familial prostate cancer in a Japanese population.Methods: We performed a case–control study consisting of 81 familial prostate cancer cases and 105 normal control subjects. Three genetic polymorphisms (BsmI, ApaI and TaqI) in the VDR gene were examined by the restriction fragment restriction length polymorphism method.Results: Overall, there was no significant association of the VDR gene polymorphisms with familial prostate cancer risk in the cases and control subjects. However, a weak association between BsmI or TaqI genotypes and cancer risk was observed in subjects under 70 years of age. Stratification of cases by clinical stage or pathological grade did not show significant association between the VDR gene polymorphisms and prostate cancer risk.Conclusion: In the present study, we could not confirm any significant association between VDR gene polymorphisms with familial prostate cancer risk in a Japanese population. Further large-scale case–control studies are warranted to confirm the importance of VDR gene polymorphisms in familial prostate cancer. |
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Vitamin D receptor gene polymorphism in familial prostate cancer in a Japanese population |
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SUZUKI, KAZUHIRO MATSUI, HIROSHI OHTAKE, NOBUAKI NAKATA, SEIJI TAKEI, TOMOYUKI KOIKE, HIDEKAZU NAKAZATO, HARUKI OKUGI, HIRONOBU HASUMI, MASARU FUKABORI, YOSHITATSU KUROKAWA, KOHEI YAMANAKA, HIDETOSHI |
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SUZUKI, KAZUHIRO MATSUI, HIROSHI OHTAKE, NOBUAKI NAKATA, SEIJI TAKEI, TOMOYUKI KOIKE, HIDEKAZU NAKAZATO, HARUKI OKUGI, HIRONOBU HASUMI, MASARU FUKABORI, YOSHITATSU KUROKAWA, KOHEI YAMANAKA, HIDETOSHI |
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