Dermatomal lichenoid graft-versus-host disease within herpes zoster scars
Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Anli, Hatice [verfasserIn] Anadolu, Rana [verfasserIn] Arat, Mutlu [verfasserIn] Ekmekci, Pelin - MD |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2003 |
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Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: International journal of dermatology - Oxford [u.a.] : Wiley-Blackwell, 1970, 42(2003), 7, Seite 0 |
| Übergeordnetes Werk: |
volume:42 ; year:2003 ; number:7 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-4362.2003.01723_2.x |
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| Katalog-ID: |
NLEJ24271532X |
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| 245 | 1 | 0 | |a Dermatomal lichenoid graft-versus-host disease within herpes zoster scars |
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| 520 | |a Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes | ||
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| 700 | 1 | |a Arat, Mutlu |e verfasserin |4 aut | |
| 700 | 1 | |a Ekmekci, Pelin |c MD |4 oth | |
| 700 | 1 | |a Birol, Ahu |4 oth | |
| 700 | 1 | |a Erdem, Cengizhan |4 oth | |
| 700 | 1 | |a Koç, Haluk |4 oth | |
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10.1046/j.1365-4362.2003.01723_2.x doi (DE-627)NLEJ24271532X DE-627 ger DE-627 rakwb Anli, Hatice verfasserin aut Dermatomal lichenoid graft-versus-host disease within herpes zoster scars Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Anadolu, Rana verfasserin aut Arat, Mutlu verfasserin aut Ekmekci, Pelin MD oth Birol, Ahu oth Erdem, Cengizhan oth Koç, Haluk oth In International journal of dermatology Oxford [u.a.] : Wiley-Blackwell, 1970 42(2003), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927347 (DE-600)2020365-2 1365-4632 nnns volume:42 year:2003 number:7 pages:0 http://dx.doi.org/10.1046/j.1365-4362.2003.01723_2.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 2003 7 0 |
| spelling |
10.1046/j.1365-4362.2003.01723_2.x doi (DE-627)NLEJ24271532X DE-627 ger DE-627 rakwb Anli, Hatice verfasserin aut Dermatomal lichenoid graft-versus-host disease within herpes zoster scars Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Anadolu, Rana verfasserin aut Arat, Mutlu verfasserin aut Ekmekci, Pelin MD oth Birol, Ahu oth Erdem, Cengizhan oth Koç, Haluk oth In International journal of dermatology Oxford [u.a.] : Wiley-Blackwell, 1970 42(2003), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927347 (DE-600)2020365-2 1365-4632 nnns volume:42 year:2003 number:7 pages:0 http://dx.doi.org/10.1046/j.1365-4362.2003.01723_2.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 2003 7 0 |
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10.1046/j.1365-4362.2003.01723_2.x doi (DE-627)NLEJ24271532X DE-627 ger DE-627 rakwb Anli, Hatice verfasserin aut Dermatomal lichenoid graft-versus-host disease within herpes zoster scars Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Anadolu, Rana verfasserin aut Arat, Mutlu verfasserin aut Ekmekci, Pelin MD oth Birol, Ahu oth Erdem, Cengizhan oth Koç, Haluk oth In International journal of dermatology Oxford [u.a.] : Wiley-Blackwell, 1970 42(2003), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927347 (DE-600)2020365-2 1365-4632 nnns volume:42 year:2003 number:7 pages:0 http://dx.doi.org/10.1046/j.1365-4362.2003.01723_2.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 2003 7 0 |
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10.1046/j.1365-4362.2003.01723_2.x doi (DE-627)NLEJ24271532X DE-627 ger DE-627 rakwb Anli, Hatice verfasserin aut Dermatomal lichenoid graft-versus-host disease within herpes zoster scars Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Anadolu, Rana verfasserin aut Arat, Mutlu verfasserin aut Ekmekci, Pelin MD oth Birol, Ahu oth Erdem, Cengizhan oth Koç, Haluk oth In International journal of dermatology Oxford [u.a.] : Wiley-Blackwell, 1970 42(2003), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927347 (DE-600)2020365-2 1365-4632 nnns volume:42 year:2003 number:7 pages:0 http://dx.doi.org/10.1046/j.1365-4362.2003.01723_2.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 2003 7 0 |
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10.1046/j.1365-4362.2003.01723_2.x doi (DE-627)NLEJ24271532X DE-627 ger DE-627 rakwb Anli, Hatice verfasserin aut Dermatomal lichenoid graft-versus-host disease within herpes zoster scars Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Anadolu, Rana verfasserin aut Arat, Mutlu verfasserin aut Ekmekci, Pelin MD oth Birol, Ahu oth Erdem, Cengizhan oth Koç, Haluk oth In International journal of dermatology Oxford [u.a.] : Wiley-Blackwell, 1970 42(2003), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927347 (DE-600)2020365-2 1365-4632 nnns volume:42 year:2003 number:7 pages:0 http://dx.doi.org/10.1046/j.1365-4362.2003.01723_2.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 42 2003 7 0 |
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Dermatomal lichenoid graft-versus-host disease within herpes zoster scars |
| abstract |
Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes |
| abstractGer |
Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes |
| abstract_unstemmed |
Case 1 A 23-year-old woman was diagnosed with chronic myelogenous leukemia in 1997. In 1999, she underwent allogeneic bone marrow transplantation (BMT) from a human leukocyte antigen (HLA)-matched sibling donor after induction chemotherapy with cyclophosphamide and busulfan. At day 46 after BMT, she was discharged with a medication regimen which included cyclosporine, fluconazole, acyclovir, and trimethoprim/sulfamethoxazole. Five months later she developed clusters of vesicles and pain over the right inframammary and right infrascapular areas corresponding to the T5–T6 dermatomes. Herpes zoster infection was diagnosed clinically and acyclovir therapy (3 × 10 mg/kg/day) was started. All lesions healed within 2 weeks leaving atrophic cicatrices and postinflammatory hyperpigmentation.Eight months after BMT, she presented with erythematous and hyperpigmented macules on the malar areas. Follicular hyperkeratosis on the chest and interscapular area, reticulated white plaques on the buccal mucosa, and significant xerosis were also observed on dermatologic examination. Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. She underwent allogeneic BMT from an HLA-matched sibling donor after a preoperative chemotherapy regimen with cyclophosphamide and busulfan in 1999.At day 20, she developed erythema and a burning sensation on her palms and soles and erythema, hyperpigmentation, and desquamation on her face and neck. The lesions increased gradually within 3 weeks. Dermatologic examination on day 40 revealed widespread violaceous, lichenoid papules and plaques on the face, neck, trunk, upper extremities, and genital region. There were also reticulated, white plaques on the buccal mucosa. A biopsy obtained from the lesions on the neck showed findings consistent with both acute and lichenoid GVHD. The skin lesions resolved within 1 month after prednisolone therapy leaving postinflammatory hyperpigmentation.Seven months later, she developed herpes zoster infection involving the right neck, shoulder, chest, and scapular area corresponding to the C3–C4 dermatomes. She was treated with famcyclovir for 10 days and the lesions healed completely. Three months after this infection, new, violaceous, lichenoid papular lesions were noted which remained confined to the dermatomes affected by the herpes zoster infection (<link href="#f3">Fig. 3). Dermatopathologic examination revealed dyskeratotic cells, focal vacuolization in the basal cell layer, and a superficial band-like lymphocytic infiltrate in the papillary dermis, consistent with lichenoid chronic GVHD.<figure xml:id="f3">3<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f3"/>Lichenoid papules located on C3–C4 dermatomes |
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Dermatomal lichenoid graft-versus-host disease within herpes zoster scars |
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Anadolu, Rana Arat, Mutlu Ekmekci, Pelin MD Birol, Ahu Erdem, Cengizhan Koç, Haluk |
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Dermatopathologic examination of a biopsy specimen obtained from the lesions on the face was evaluated to be consistent with “atrophic folliculocentric lichen planus.” Two weeks later she was admitted again for new lesions on the trunk. Flat, violaceous, slightly scaly papules were located exactly on the dermatomes of the previous herpes zoster infection (<link href="#f1">Fig. 1). A biopsy specimen of these lesions showed a dense, subepidermal, band-like, lymphocytic inflammatory infiltrate, vacuolar degeneration of the basal cell layer, and scattered dyskeratotic cells in the epidermis, confirming the diagnosis of lichenoid graft-versus-host disease (GVHD) (<link href="#f2">Fig. 2a and 2b).<figure xml:id="f1">1<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f1"/>Lichenoid lesions on the dermatomes of a previous herpes zoster infection<figure xml:id="f2">2<mediaResource alt="image" href="urn:x-wiley:00119059:IJD1803_2:IJD_1803_f2"/>(a) Dense, subepidermal, band-like, lymphocytic infiltrate, vacuolar degeneration of the basal cell layer, and dyskeratotic cells in the epidermis (hematoxylin and eosin, ¥ 50). (b) Vacuolar degeneration of the basal cell layer,scattered dyskeratotic cells, and satellite cell necrosis (hematoxylin and eosin, ¥ 100)Case 2 A 47-year-old woman was diagnosed with chronic myelogenous leukemia in 1998. 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