The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis
Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href=&q...
Ausführliche Beschreibung
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| Autor*in: |
Lee, Kun-Kook [verfasserIn] Choi, Jung-Do [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Dordrecht, The Netherlands: Blackwell Science Ltd ; 1999 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: International journal of cosmetic science - Oxford : Wiley-Blackwell, 1979, 21(1999), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:21 ; year:1999 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1467-2494.1999.196590.x |
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| Katalog-ID: |
NLEJ242742556 |
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| 245 | 1 | 0 | |a The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis |
| 264 | 1 | |a Dordrecht, The Netherlands |b Blackwell Science Ltd |c 1999 | |
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| 520 | |a Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. | ||
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10.1046/j.1467-2494.1999.196590.x doi (DE-627)NLEJ242742556 DE-627 ger DE-627 rakwb Lee, Kun-Kook verfasserin aut The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Dordrecht, The Netherlands Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| Areca catechu Choi, Jung-Do verfasserin aut In International journal of cosmetic science Oxford : Wiley-Blackwell, 1979 21(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392691X (DE-600)1484465-5 1468-2494 nnns volume:21 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1467-2494.1999.196590.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1999 4 0 |
| spelling |
10.1046/j.1467-2494.1999.196590.x doi (DE-627)NLEJ242742556 DE-627 ger DE-627 rakwb Lee, Kun-Kook verfasserin aut The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Dordrecht, The Netherlands Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| Areca catechu Choi, Jung-Do verfasserin aut In International journal of cosmetic science Oxford : Wiley-Blackwell, 1979 21(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392691X (DE-600)1484465-5 1468-2494 nnns volume:21 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1467-2494.1999.196590.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1999 4 0 |
| allfields_unstemmed |
10.1046/j.1467-2494.1999.196590.x doi (DE-627)NLEJ242742556 DE-627 ger DE-627 rakwb Lee, Kun-Kook verfasserin aut The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Dordrecht, The Netherlands Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| Areca catechu Choi, Jung-Do verfasserin aut In International journal of cosmetic science Oxford : Wiley-Blackwell, 1979 21(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392691X (DE-600)1484465-5 1468-2494 nnns volume:21 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1467-2494.1999.196590.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1999 4 0 |
| allfieldsGer |
10.1046/j.1467-2494.1999.196590.x doi (DE-627)NLEJ242742556 DE-627 ger DE-627 rakwb Lee, Kun-Kook verfasserin aut The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Dordrecht, The Netherlands Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| Areca catechu Choi, Jung-Do verfasserin aut In International journal of cosmetic science Oxford : Wiley-Blackwell, 1979 21(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392691X (DE-600)1484465-5 1468-2494 nnns volume:21 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1467-2494.1999.196590.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1999 4 0 |
| allfieldsSound |
10.1046/j.1467-2494.1999.196590.x doi (DE-627)NLEJ242742556 DE-627 ger DE-627 rakwb Lee, Kun-Kook verfasserin aut The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Dordrecht, The Netherlands Blackwell Science Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| Areca catechu Choi, Jung-Do verfasserin aut In International journal of cosmetic science Oxford : Wiley-Blackwell, 1979 21(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ24392691X (DE-600)1484465-5 1468-2494 nnns volume:21 year:1999 number:4 pages:0 http://dx.doi.org/10.1046/j.1467-2494.1999.196590.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 21 1999 4 0 |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242742556</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707163436.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1999 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1467-2494.1999.196590.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242742556</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lee, Kun-Kook</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Dordrecht, The Netherlands</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. 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Lee, Kun-Kook |
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Lee, Kun-Kook misc Areca catechu The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis |
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The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis Areca catechu |
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the effects of areca catechu l extract on anti-inflammation and anti-melanogenesis |
| title_auth |
The Effects of Areca Catechu L Extract on Anti-Inflammation and Anti-Melanogenesis |
| abstract |
Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. |
| abstractGer |
Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. |
| abstract_unstemmed |
Ethanolic extract (CC-516) from Areca catechu L was prepared and its various biological activities were evaluated, CC-516 showed potent anti-oxidative, free radical scavenging, and anti-hyaluronidase activity. Anti-oxidative effect of CC-516 (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu1" location="equation/ICS_196590_mu1.gif" extraInfo="missing"/>: 45.4 μg/ml) was lower than butylated hydroxytoluene (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu2" location="equation/ICS_196590_mu2.gif" extraInfo="missing"/>: 5μg ml), but similar to tocopherol and higher than ascorbic acid. Especially, CC-516 exhibited relatively high free radical scavenging activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu3" location="equation/ICS_196590_mu3.gif" extraInfo="missing"/>: 10.2 μg/ml) compared to control. CC-516 inhibited effectively hyaluronidase activity (IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu4" location="equation/ICS_196590_mu4.gif" extraInfo="missing"/>: 416 μg/ml), showed inhibition in vivo on delayed hypersensitivity as well as croton-oil induced ear edema in mice when it was topically applied. These results strongly suggest that CC-516 may reduce immunoregulatory/inflammatory skin trouble. Also, from the results, we have elucidated that CC-516 showed anti-allergic and anti-cytotoxicity activity. The whitening effect of CC-516 shown by the inhibition of mushroom tyrosinase activity with IC <inlineGraphic alt="inline image" href="urn:x-wiley:01425463:ICS196590:ICS_196590_mu5" location="equation/ICS_196590_mu5.gif" extraInfo="missing"/> of 0.48 mg/ml and of melanin synthesis in B16 melanoma cells. This study indicates that CC-516 is effective on anti-inflammatory/anti-melanogenesis, and can be used as a new agent for cosmetics. |
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