Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts
Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, a...
Ausführliche Beschreibung
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| Autor*in: |
De Silva, M V C [verfasserIn] Raby, N [verfasserIn] Reid, R [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2003 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Histopathology - Oxford [u.a.] : Wiley-Blackwell, 1977, 43(2003), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:43 ; year:2003 ; number:2 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1046/j.1365-2559.2003.01666.x |
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NLEJ242761852 |
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| 245 | 1 | 0 | |a Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts |
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| 520 | |a Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. | ||
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10.1046/j.1365-2559.2003.01666.x doi (DE-627)NLEJ242761852 DE-627 ger DE-627 rakwb De Silva, M V C verfasserin aut Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| aneurysmal bone cyst Raby, N verfasserin aut Reid, R verfasserin aut In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 43(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:43 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2003.01666.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 2003 2 0 |
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10.1046/j.1365-2559.2003.01666.x doi (DE-627)NLEJ242761852 DE-627 ger DE-627 rakwb De Silva, M V C verfasserin aut Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| aneurysmal bone cyst Raby, N verfasserin aut Reid, R verfasserin aut In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 43(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:43 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2003.01666.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 2003 2 0 |
| allfields_unstemmed |
10.1046/j.1365-2559.2003.01666.x doi (DE-627)NLEJ242761852 DE-627 ger DE-627 rakwb De Silva, M V C verfasserin aut Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| aneurysmal bone cyst Raby, N verfasserin aut Reid, R verfasserin aut In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 43(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:43 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2003.01666.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 2003 2 0 |
| allfieldsGer |
10.1046/j.1365-2559.2003.01666.x doi (DE-627)NLEJ242761852 DE-627 ger DE-627 rakwb De Silva, M V C verfasserin aut Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| aneurysmal bone cyst Raby, N verfasserin aut Reid, R verfasserin aut In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 43(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:43 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2003.01666.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 2003 2 0 |
| allfieldsSound |
10.1046/j.1365-2559.2003.01666.x doi (DE-627)NLEJ242761852 DE-627 ger DE-627 rakwb De Silva, M V C verfasserin aut Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts Oxford, UK Blackwell Science Ltd 2003 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| aneurysmal bone cyst Raby, N verfasserin aut Reid, R verfasserin aut In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 43(2003), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:43 year:2003 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2003.01666.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 43 2003 2 0 |
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The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. 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Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts |
| abstract |
Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. |
| abstractGer |
Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. |
| abstract_unstemmed |
Aims: Primary aneurysmal bone cysts have a high recurrence rate following curettage. The aim of this study was to determine clinicopathological features associated with recurrence of aneurysmal bone cysts.Methods and results: The clinicopathological features of 86 patients (37 males, 49 females, age range 5–62 years) with aneurysmal bone cysts were reviewed. Recurrence rates following curettage and excision were 32.7% and 5.6%, respectively (P = 0.028). The association of clinicopathological features with recurrence was studied in a subset of 45 patients treated by curettage. The presence of nodular fasciitis-like fibromyxoid areas [P = 0.033, odds ratio (OR) = 9.17, 95% confidence interval (CI) 1.06, 79.39] and immature osteoid with active osteoblasts (P = 0.041, OR = 3.7, 95% CI 1.03, 13.35) was significantly associated with an increased risk of recurrence. Clinical and radiological features were not associated with recurrence. In a multivariate analysis, the presence of immature osteoid was a better predictor of recurrence than radiological activity (hazard ratio = 3.18, 95% CI 1.04, 9.73, P = 0.043). There was no statistically significant association between radiological activity and histological features.Conclusions: Aneurysmal bone cysts with nodular fasciitis-like fibromyxoid areas and immature osteoid with active osteoblasts are more likely to recur. Mention of these features in histopathology reports will help to identify patients who require closer follow-up. Lesions that are apparently radiologically inactive may show fibroblastic and osteoblastic proliferation and therefore may recur. |
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Fibromyxoid areas and immature osteoid are associated with recurrence of primary aneurysmal bone cysts |
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Raby, N Reid, R |
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2024-07-06T03:06:13.355Z |
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