Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expressio...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Liu, X P [verfasserIn] Kawauchi, S [verfasserIn] Oga, A [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford UK: Blackwell Science Ltd ; 2001 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Histopathology - Oxford [u.a.] : Wiley-Blackwell, 1977, 39(2001), 6, Seite 0 |
| Übergeordnetes Werk: |
volume:39 ; year:2001 ; number:6 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1365-2559.2001.01283.x |
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NLEJ242766218 |
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| 520 | |a Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. | ||
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10.1046/j.1365-2559.2001.01283.x doi (DE-627)NLEJ242766218 DE-627 ger DE-627 rakwb Liu, X P verfasserin aut Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gastric carcinoma Kawauchi, S verfasserin aut Oga, A verfasserin aut Suehiro, Y oth Tsushimi, K oth Tsushimi, M oth Sasaki, K oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:6 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01283.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 6 0 |
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10.1046/j.1365-2559.2001.01283.x doi (DE-627)NLEJ242766218 DE-627 ger DE-627 rakwb Liu, X P verfasserin aut Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gastric carcinoma Kawauchi, S verfasserin aut Oga, A verfasserin aut Suehiro, Y oth Tsushimi, K oth Tsushimi, M oth Sasaki, K oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:6 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01283.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 6 0 |
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10.1046/j.1365-2559.2001.01283.x doi (DE-627)NLEJ242766218 DE-627 ger DE-627 rakwb Liu, X P verfasserin aut Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gastric carcinoma Kawauchi, S verfasserin aut Oga, A verfasserin aut Suehiro, Y oth Tsushimi, K oth Tsushimi, M oth Sasaki, K oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:6 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01283.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 6 0 |
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10.1046/j.1365-2559.2001.01283.x doi (DE-627)NLEJ242766218 DE-627 ger DE-627 rakwb Liu, X P verfasserin aut Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gastric carcinoma Kawauchi, S verfasserin aut Oga, A verfasserin aut Suehiro, Y oth Tsushimi, K oth Tsushimi, M oth Sasaki, K oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:6 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01283.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 6 0 |
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10.1046/j.1365-2559.2001.01283.x doi (DE-627)NLEJ242766218 DE-627 ger DE-627 rakwb Liu, X P verfasserin aut Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| gastric carcinoma Kawauchi, S verfasserin aut Oga, A verfasserin aut Suehiro, Y oth Tsushimi, K oth Tsushimi, M oth Sasaki, K oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 6, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:6 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01283.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 6 0 |
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Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma gastric carcinoma |
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Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma |
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Liu, X P |
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Histopathology |
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Liu, X P Kawauchi, S Oga, A |
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Liu, X P |
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combined examination of p27kip1, p21waf1/cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma |
| title_auth |
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma |
| abstract |
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. |
| abstractGer |
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. |
| abstract_unstemmed |
Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma Aims: In order to estimate the prognostic values of p27Kip1, p21Waf1/Cip1, and p53, alone and in combination, we investigated immunohistochemically the expression of p27Kip1, p21Waf1/Cip1, and p53 proteins in gastric carcinomas. Methods and results: The expression of p27Kip1, p21Waf1/Cip1, and p53 was immunohistochemically examined in 140 gastric carcinomas. Positive expression of p27Kip1 and p21Waf1/Cip1 correlated significantly with a favourable prognosis (P < 0.05), whereas, positive expression of p53 tended to correlate with poor prognosis. Multivariate survival analysis revealed that TNM stage of tumour (P < 0.001), lymph node state (P=0.005), and p27Kip1 expression (P=0.006) were independent prognostic factors. A striking stratification of mortality rate was found when patients were divided into four groups according to the expression of p21Waf1/Cip1 and p27Kip1. The mortality rate was higher in patients with both p21Waf1/Cip1- and p27Kip1-negative gastric carcinoma than in patients with one or both positive carcinomas (P < 0.01). In addition, if the four p21Waf1/Cip1/p27Kip1 groups were compared based on p53 status, p53+ cases tended to have a higher mortality rate than p53- cases. Conclusion: Our results suggest that low expression of both p27Kip1 and p21Waf1/Cip1 could be useful as markers of poorer prognosis, and the combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows reliable estimation of prognosis for patients with gastric carcinoma. |
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Combined examination of p27Kip1, p21Waf1/Cip1 and p53 expression allows precise estimation of prognosis in patients with gastric carcinoma |
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Kawauchi, S Oga, A Suehiro, Y Tsushimi, K Tsushimi, M Sasaki, K |
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