Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma
Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas...
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| Autor*in: |
Yamato, H [verfasserIn] Ohshima, K [verfasserIn] Suzumiya, J [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford UK: Blackwell Science Ltd ; 2001 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2001 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Histopathology - Oxford [u.a.] : Wiley-Blackwell, 1977, 39(2001), 2, Seite 0 |
| Übergeordnetes Werk: |
volume:39 ; year:2001 ; number:2 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1365-2559.2001.01197.x |
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| 520 | |a Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. | ||
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10.1046/j.1365-2559.2001.01197.x doi (DE-627)NLEJ242767168 DE-627 ger DE-627 rakwb Yamato, H verfasserin aut Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| PAL Ohshima, K verfasserin aut Suzumiya, J verfasserin aut Kikuchi, M oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 2 0 |
| spelling |
10.1046/j.1365-2559.2001.01197.x doi (DE-627)NLEJ242767168 DE-627 ger DE-627 rakwb Yamato, H verfasserin aut Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| PAL Ohshima, K verfasserin aut Suzumiya, J verfasserin aut Kikuchi, M oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 2 0 |
| allfields_unstemmed |
10.1046/j.1365-2559.2001.01197.x doi (DE-627)NLEJ242767168 DE-627 ger DE-627 rakwb Yamato, H verfasserin aut Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| PAL Ohshima, K verfasserin aut Suzumiya, J verfasserin aut Kikuchi, M oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 2 0 |
| allfieldsGer |
10.1046/j.1365-2559.2001.01197.x doi (DE-627)NLEJ242767168 DE-627 ger DE-627 rakwb Yamato, H verfasserin aut Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| PAL Ohshima, K verfasserin aut Suzumiya, J verfasserin aut Kikuchi, M oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 2 0 |
| allfieldsSound |
10.1046/j.1365-2559.2001.01197.x doi (DE-627)NLEJ242767168 DE-627 ger DE-627 rakwb Yamato, H verfasserin aut Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Oxford UK Blackwell Science Ltd 2001 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. 2001 Blackwell Publishing Journal Backfiles 1879-2005 |2001|||||||||| PAL Ohshima, K verfasserin aut Suzumiya, J verfasserin aut Kikuchi, M oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 39(2001), 2, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:39 year:2001 number:2 pages:0 http://dx.doi.org/10.1046/j.1365-2559.2001.01197.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 39 2001 2 0 |
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Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma |
| abstract |
Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. |
| abstractGer |
Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. |
| abstract_unstemmed |
Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma Aims: Pyothorax-associated lymphoma (PAL) develops in the pleural cavity of patients with a long history of pyothorax. Epstein–Barr virus (EBV) is also involved in PAL, similar to lymphomas in immunodeficient patients. Here we examined T-lymphocyte subsets as well as c-myc and REL gene amplification in PAL tissues. Methods and results: We determined the number and distribution of CD4+ and CD8+ T-lymphocytes, to evaluate T-cells in the host immune reaction in seven cases of PAL. As controls, we also studied 10 cases of extranodal diffuse large B-cell lymphoma (DLBL) and 10 cases of nodal DLBL. Chromosomal imbalances in PAL were determined by using comparative genomic hybridization (CGH) analysis. The mean numbers of CD4+ and CD8+ and their ratio were significantly lower in PAL than in nodal DLBL. CGH analysis of PAL showed amplification of the 8q24 chromosomal region. In addition, c-myc amplification was found in four cases of PAL by Southern blot analysis. Conclusions: Our results suggest that the development of PAL may involve a local immunosuppressive environment and that amplification of c-myc might promote tumour progression, as has been described in the development of Burkitt’s lymphoma. |
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Evidence for local immunosuppression and demonstration of c-myc amplification in pyothorax-associated lymphoma |
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Ohshima, K Suzumiya, J Kikuchi, M |
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