Thyroid carcinoma associated with familial adenomatous polyposis
Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morpholog...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
CETTA, F. [verfasserIn] TOTI, P. [verfasserIn] PETRACCI, M. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 1997 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Histopathology - Oxford [u.a.] : Wiley-Blackwell, 1977, 31(1997), 3, Seite 0 |
| Übergeordnetes Werk: |
volume:31 ; year:1997 ; number:3 ; pages:0 |
| Links: |
|---|
| DOI / URN: |
10.1046/j.1365-2559.1997.2390858.x |
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NLEJ242776116 |
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| 520 | |a Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. | ||
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10.1046/j.1365-2559.1997.2390858.x doi (DE-627)NLEJ242776116 DE-627 ger DE-627 rakwb CETTA, F. verfasserin aut Thyroid carcinoma associated with familial adenomatous polyposis Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| thyroid carcinoma TOTI, P. verfasserin aut PETRACCI, M. verfasserin aut MONTALTO, G. oth DISANTO, A. oth LORÈ, F. oth FUSCO, A. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 31(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:31 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2559.1997.2390858.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 31 1997 3 0 |
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10.1046/j.1365-2559.1997.2390858.x doi (DE-627)NLEJ242776116 DE-627 ger DE-627 rakwb CETTA, F. verfasserin aut Thyroid carcinoma associated with familial adenomatous polyposis Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| thyroid carcinoma TOTI, P. verfasserin aut PETRACCI, M. verfasserin aut MONTALTO, G. oth DISANTO, A. oth LORÈ, F. oth FUSCO, A. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 31(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:31 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2559.1997.2390858.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 31 1997 3 0 |
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10.1046/j.1365-2559.1997.2390858.x doi (DE-627)NLEJ242776116 DE-627 ger DE-627 rakwb CETTA, F. verfasserin aut Thyroid carcinoma associated with familial adenomatous polyposis Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| thyroid carcinoma TOTI, P. verfasserin aut PETRACCI, M. verfasserin aut MONTALTO, G. oth DISANTO, A. oth LORÈ, F. oth FUSCO, A. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 31(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:31 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2559.1997.2390858.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 31 1997 3 0 |
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10.1046/j.1365-2559.1997.2390858.x doi (DE-627)NLEJ242776116 DE-627 ger DE-627 rakwb CETTA, F. verfasserin aut Thyroid carcinoma associated with familial adenomatous polyposis Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| thyroid carcinoma TOTI, P. verfasserin aut PETRACCI, M. verfasserin aut MONTALTO, G. oth DISANTO, A. oth LORÈ, F. oth FUSCO, A. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 31(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:31 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2559.1997.2390858.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 31 1997 3 0 |
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10.1046/j.1365-2559.1997.2390858.x doi (DE-627)NLEJ242776116 DE-627 ger DE-627 rakwb CETTA, F. verfasserin aut Thyroid carcinoma associated with familial adenomatous polyposis Oxford, UK Blackwell Science Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| thyroid carcinoma TOTI, P. verfasserin aut PETRACCI, M. verfasserin aut MONTALTO, G. oth DISANTO, A. oth LORÈ, F. oth FUSCO, A. oth In Histopathology Oxford [u.a.] : Wiley-Blackwell, 1977 31(1997), 3, Seite 0 Online-Ressource (DE-627)NLEJ243927045 (DE-600)2006447-0 1365-2559 nnns volume:31 year:1997 number:3 pages:0 http://dx.doi.org/10.1046/j.1365-2559.1997.2390858.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 31 1997 3 0 |
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Thyroid carcinoma associated with familial adenomatous polyposis |
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Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. |
| abstractGer |
Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. |
| abstract_unstemmed |
Thyroid carcinoma is an extracolonic manifestation that is present in about 1% to 2% of patients with familial adenomatous polyposis (FAP). Less than 100 cases have been reported in detail. We have investigated the suggestion that FAP associated thyroid carcinoma is significantly different morphologically from both papillary and follicular types and can be considered as a separate entity.<section xml:id="abs1-2"><title type="main">Methods and results:Specimens from three patients with FAP associated thyroid tumours, all but one having single nodules, have been analysed. All three patients belonged to an extended kindred (23 siblings in four generations) who had genetic analysis and intensive screening for thyroid nodules. Seven patients had the same APC mutation at codon 1061. Pathological examination revealed a typical papillary carcinoma, encapsulated variant, in all patients, with follicular areas in one case. All thyroid specimens, in addition to histological and immunohistological examinations, were also specifically studied for activation of the RET-PTC oncogene, that seems to be restricted to papillary thyroid carcinoma. Two of the three patients had RET-PTC activation (PTC1 isoform).<section xml:id="abs1-3"><title type="main">Conclusions:The findings suggest that the tumours were certainly papillary, at least in the present kindred. Further studies in different families are required for a better understanding of this peculiar tumour and of its biological behaviour. |
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