Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults
Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Kikuchi, Shogo [verfasserIn] Ohgihara, Atsushi [verfasserIn] Hasegawa, Ayako [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 2004 |
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| Schlagwörter: |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2004 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Helicobacter - Oxford [u.a.] : Wiley-Blackwell, 1996, 9(2004), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:9 ; year:2004 ; number:4 ; pages:0 |
| Links: |
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| DOI / URN: |
10.1111/j.1083-4389.2004.00233.x |
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| Katalog-ID: |
NLEJ242780997 |
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| 245 | 1 | 0 | |a Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults |
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| 520 | |a Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. | ||
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| 700 | 1 | |a Kaneko, Eizo |4 oth | |
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10.1111/j.1083-4389.2004.00233.x doi (DE-627)NLEJ242780997 DE-627 ger DE-627 rakwb Kikuchi, Shogo verfasserin aut Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| seroconversion Ohgihara, Atsushi verfasserin aut Hasegawa, Ayako verfasserin aut Miki, Kazumasa oth Kaneko, Eizo oth Mizukoshi, Hiroshi oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
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10.1111/j.1083-4389.2004.00233.x doi (DE-627)NLEJ242780997 DE-627 ger DE-627 rakwb Kikuchi, Shogo verfasserin aut Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| seroconversion Ohgihara, Atsushi verfasserin aut Hasegawa, Ayako verfasserin aut Miki, Kazumasa oth Kaneko, Eizo oth Mizukoshi, Hiroshi oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfields_unstemmed |
10.1111/j.1083-4389.2004.00233.x doi (DE-627)NLEJ242780997 DE-627 ger DE-627 rakwb Kikuchi, Shogo verfasserin aut Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| seroconversion Ohgihara, Atsushi verfasserin aut Hasegawa, Ayako verfasserin aut Miki, Kazumasa oth Kaneko, Eizo oth Mizukoshi, Hiroshi oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfieldsGer |
10.1111/j.1083-4389.2004.00233.x doi (DE-627)NLEJ242780997 DE-627 ger DE-627 rakwb Kikuchi, Shogo verfasserin aut Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| seroconversion Ohgihara, Atsushi verfasserin aut Hasegawa, Ayako verfasserin aut Miki, Kazumasa oth Kaneko, Eizo oth Mizukoshi, Hiroshi oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfieldsSound |
10.1111/j.1083-4389.2004.00233.x doi (DE-627)NLEJ242780997 DE-627 ger DE-627 rakwb Kikuchi, Shogo verfasserin aut Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| seroconversion Ohgihara, Atsushi verfasserin aut Hasegawa, Ayako verfasserin aut Miki, Kazumasa oth Kaneko, Eizo oth Mizukoshi, Hiroshi oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
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Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. 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Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults |
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Kikuchi, Shogo |
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Helicobacter |
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Helicobacter |
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2004 |
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Kikuchi, Shogo Ohgihara, Atsushi Hasegawa, Ayako |
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9 |
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Online-Ressource |
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Elektronische Aufsätze |
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Kikuchi, Shogo |
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10.1111/j.1083-4389.2004.00233.x |
| author2-role |
verfasserin |
| title_sort |
seroconversion and seroreversion of helicobacter pylori antibodies over a 9-year period and related factors in japanese adults |
| title_auth |
Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults |
| abstract |
Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. |
| abstractGer |
Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. |
| abstract_unstemmed |
Background. There are still insufficient data on the frequency of seroconversion and seroreversion of Helicobacter pylori antibodies. The frequency of serochange and related factors were investigated in this study over 9 years.Subjects and methods. Using sera from 3104 workers who underwent health checks in 1989 and again in 1998, H. pylori antibodies were measured. Those with intermediate serology were excluded from the study. Information on past history was collected using a questionnaire.Results. Of the 912 seronegative and 1286 seropositive subjects in 1989, seroconversion was observed in 57 and seroreversion in 91 subjects. Seroconversion and seroreversion rates over the 9-year period were 6.3% and 7.1%, respectively, giving rates per 1000 person-years (with 95% confidence interval) of 7.0 (5.2–8.7) and 7.9 (6.3–9.4), respectively. Subjects that reported abdominal symptoms or gastric fiberscope use showed significantly higher seroconversion rates than controls (8.7 vs. 4.5 and 9.2 vs. 1.6, respectively), which remained significant after adjustment for age and gender. Those with a history of duodenal ulcers, a smoking habit or a drinking habit showed significantly lower seroreversion rates than controls (3.5 vs. 8.9, 5.4 vs. 9.2 and 5.9 vs. 13.3, respectively). After adjustment, the association between seroreversion and smoking habit disappeared, while the associations with history of duodenal ulcers and drinking habit remained.Conclusions. Those with a history of nonspecific abdominal symptoms and those with a history of gastric fiberscope use showed higher seroconversion rates. Alcohol consumption and duodenal ulcers may inhibit the autoeradication of H. pylori, possibly through increased acid secretion. |
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4 |
| title_short |
Seroconversion and Seroreversion of Helicobacter pylori Antibodies Over a 9-Year Period and Related Factors in Japanese Adults |
| url |
http://dx.doi.org/10.1111/j.1083-4389.2004.00233.x |
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| author2 |
Ohgihara, Atsushi Hasegawa, Ayako Miki, Kazumasa Kaneko, Eizo Mizukoshi, Hiroshi |
| author2Str |
Ohgihara, Atsushi Hasegawa, Ayako Miki, Kazumasa Kaneko, Eizo Mizukoshi, Hiroshi |
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2024-07-06T03:10:09.764Z |
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