Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial
Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multice...
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Oxford, UK: Blackwell Science Ltd ; 2004 |
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Online-Ressource |
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2004 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Helicobacter - Oxford [u.a.] : Wiley-Blackwell, 1996, 9(2004), 4, Seite 0 |
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volume:9 ; year:2004 ; number:4 ; pages:0 |
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| DOI / URN: |
10.1111/j.1083-4389.2004.00242.x |
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NLEJ24278108X |
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| 245 | 1 | 0 | |a Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial |
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| 520 | |a Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. | ||
| 533 | |d 2004 |f Blackwell Publishing Journal Backfiles 1879-2005 |7 |2004|||||||||| | ||
| 700 | 1 | |a Oderda, Giuseppina |4 oth | |
| 700 | 1 | |a Marinello, Daniela |4 oth | |
| 700 | 1 | |a Lerro, Pietro |4 oth | |
| 700 | 1 | |a Kuvidi, Maria |4 oth | |
| 700 | 1 | |a De’Angelis, Gian Luigi |4 oth | |
| 700 | 1 | |a Ferzetti, Anna |4 oth | |
| 700 | 1 | |a Cucchiara, Salvatore |4 oth | |
| 700 | 1 | |a Franco, Maria Teresa |4 oth | |
| 700 | 1 | |a Romano, Claudio |4 oth | |
| 700 | 1 | |a Strisciuglio, Pietro |4 oth | |
| 700 | 1 | |a Pensabene, Lucia |4 oth | |
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10.1111/j.1083-4389.2004.00242.x doi (DE-627)NLEJ24278108X DE-627 ger DE-627 rakwb Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Oderda, Giuseppina oth Marinello, Daniela oth Lerro, Pietro oth Kuvidi, Maria oth De’Angelis, Gian Luigi oth Ferzetti, Anna oth Cucchiara, Salvatore oth Franco, Maria Teresa oth Romano, Claudio oth Strisciuglio, Pietro oth Pensabene, Lucia oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| spelling |
10.1111/j.1083-4389.2004.00242.x doi (DE-627)NLEJ24278108X DE-627 ger DE-627 rakwb Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Oderda, Giuseppina oth Marinello, Daniela oth Lerro, Pietro oth Kuvidi, Maria oth De’Angelis, Gian Luigi oth Ferzetti, Anna oth Cucchiara, Salvatore oth Franco, Maria Teresa oth Romano, Claudio oth Strisciuglio, Pietro oth Pensabene, Lucia oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfields_unstemmed |
10.1111/j.1083-4389.2004.00242.x doi (DE-627)NLEJ24278108X DE-627 ger DE-627 rakwb Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Oderda, Giuseppina oth Marinello, Daniela oth Lerro, Pietro oth Kuvidi, Maria oth De’Angelis, Gian Luigi oth Ferzetti, Anna oth Cucchiara, Salvatore oth Franco, Maria Teresa oth Romano, Claudio oth Strisciuglio, Pietro oth Pensabene, Lucia oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfieldsGer |
10.1111/j.1083-4389.2004.00242.x doi (DE-627)NLEJ24278108X DE-627 ger DE-627 rakwb Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Oderda, Giuseppina oth Marinello, Daniela oth Lerro, Pietro oth Kuvidi, Maria oth De’Angelis, Gian Luigi oth Ferzetti, Anna oth Cucchiara, Salvatore oth Franco, Maria Teresa oth Romano, Claudio oth Strisciuglio, Pietro oth Pensabene, Lucia oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
| allfieldsSound |
10.1111/j.1083-4389.2004.00242.x doi (DE-627)NLEJ24278108X DE-627 ger DE-627 rakwb Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial Oxford, UK Blackwell Science Ltd 2004 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. 2004 Blackwell Publishing Journal Backfiles 1879-2005 |2004|||||||||| Oderda, Giuseppina oth Marinello, Daniela oth Lerro, Pietro oth Kuvidi, Maria oth De’Angelis, Gian Luigi oth Ferzetti, Anna oth Cucchiara, Salvatore oth Franco, Maria Teresa oth Romano, Claudio oth Strisciuglio, Pietro oth Pensabene, Lucia oth In Helicobacter Oxford [u.a.] : Wiley-Blackwell, 1996 9(2004), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925727 (DE-600)2020336-6 1523-5378 nnns volume:9 year:2004 number:4 pages:0 http://dx.doi.org/10.1111/j.1083-4389.2004.00242.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 9 2004 4 0 |
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Oderda, Giuseppina @@oth@@ Marinello, Daniela @@oth@@ Lerro, Pietro @@oth@@ Kuvidi, Maria @@oth@@ De’Angelis, Gian Luigi @@oth@@ Ferzetti, Anna @@oth@@ Cucchiara, Salvatore @@oth@@ Franco, Maria Teresa @@oth@@ Romano, Claudio @@oth@@ Strisciuglio, Pietro @@oth@@ Pensabene, Lucia @@oth@@ |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ24278108X</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505221702.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2004 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1083-4389.2004.00242.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ24278108X</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">2004</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. 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Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial |
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dual vs. triple therapy for childhood helicobacter pylori gastritis: a double-blind randomized multicentre trial |
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Dual vs. Triple Therapy for Childhood Helicobacter pylori Gastritis: a Double-Blind Randomized Multicentre Trial |
| abstract |
Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. |
| abstractGer |
Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. |
| abstract_unstemmed |
Background. Data on the efficacy of eradication treatment for Helicobacter pylori gastritis in children are scarce.Aim. To evaluate the efficacy of triple therapy with lansoprazole plus amoxicillin and tinidazole vs. dual therapy with amoxicillin and tinidazole in a double-blind randomized multicentre trial, and the usefulness of eradication in terms of long-term symptom resolution.Subjects. We enrolled 43 consecutive children undergoing endoscopy for upper gastrointestinal dyspepsia with H. pylori gastritis. They underwent a 13C-urea breath test, completed a 2-week symptom diary card, and were randomized. Treatment was given in a Redidose box (Redidose Company Ltd., Brighton, UK) containing either lansoprazole-amoxicillin-tinidazole (triple therapy) or placebo plus amoxicillin-tinidazole (dual therapy) for 1 week. The completion of a 2-week symptom diary card and the performance of a breath test were repeated 6 weeks and 6 months after the end of therapy. One to two years later, a structured telephone interview was conducted with 36 of the children.Results. According to the breath test, 6 weeks after the end of therapy H. pylori was eradicated in 15 of 22 children on triple therapy [68.2%; 95% confidence interval (CI) = 45–88] and in 15 of 21 children on dual therapy (71%; 95% CI = 48–89; not significant), and 6 months after the end of therapy it was eradicated in 16 of 22 children on triple therapy (72.7%) and in 15 of 21 children on dual therapy. Six months after therapy, symptoms were analysed in 11 H. pylori-positive and 31 H. pylori-negative children, and it was found that dyspeptic symptoms had disappeared or improved in both groups, with no difference between them. One to two years later, 36 children were interviewed. Epigastric pain had recurred in three of 26 H. pylori-negative and in seven of 10 H. pylori-positive children (p = .001); in three of the latter, pain was severe and required additional treatment.Conclusion. One-week triple or dual therapy with two antibiotics achieved similar eradication rates. Soon after treatment, symptoms disappeared or improved in most children irrespective of eradication, but epigastric pain recurred in the majority of the still-infected children within 2 years. |
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Oderda, Giuseppina Marinello, Daniela Lerro, Pietro Kuvidi, Maria De’Angelis, Gian Luigi Ferzetti, Anna Cucchiara, Salvatore Franco, Maria Teresa Romano, Claudio Strisciuglio, Pietro Pensabene, Lucia |
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Oderda, Giuseppina Marinello, Daniela Lerro, Pietro Kuvidi, Maria De’Angelis, Gian Luigi Ferzetti, Anna Cucchiara, Salvatore Franco, Maria Teresa Romano, Claudio Strisciuglio, Pietro Pensabene, Lucia |
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