The destructive capabilities of the synovium in the haemophilic joint
Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating syno...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Lee, C. A. [verfasserIn] Kessler, C. M. [verfasserIn] Varon, D. [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Science Ltd ; 1998 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2003 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: Haemophilia - Oxford [u.a.] : Wiley-Blackwell, 1995, 4(1998), 4, Seite 0 |
| Übergeordnetes Werk: |
volume:4 ; year:1998 ; number:4 ; pages:0 |
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| DOI / URN: |
10.1046/j.1365-2516.1998.440506.x |
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| 520 | |a Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. | ||
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10.1046/j.1365-2516.1998.440506.x doi (DE-627)NLEJ242796923 DE-627 ger DE-627 rakwb Lee, C. A. verfasserin aut The destructive capabilities of the synovium in the haemophilic joint Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Synovium Kessler, C. M. verfasserin aut Varon, D. verfasserin aut Martinowitz, U. oth Heim, M. oth RODRIGUEZ-MERCHAN, E. C. oth In Haemophilia Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925867 (DE-600)2006344-1 1365-2516 nnns volume:4 year:1998 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 4 0 |
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10.1046/j.1365-2516.1998.440506.x doi (DE-627)NLEJ242796923 DE-627 ger DE-627 rakwb Lee, C. A. verfasserin aut The destructive capabilities of the synovium in the haemophilic joint Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Synovium Kessler, C. M. verfasserin aut Varon, D. verfasserin aut Martinowitz, U. oth Heim, M. oth RODRIGUEZ-MERCHAN, E. C. oth In Haemophilia Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925867 (DE-600)2006344-1 1365-2516 nnns volume:4 year:1998 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 4 0 |
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10.1046/j.1365-2516.1998.440506.x doi (DE-627)NLEJ242796923 DE-627 ger DE-627 rakwb Lee, C. A. verfasserin aut The destructive capabilities of the synovium in the haemophilic joint Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Synovium Kessler, C. M. verfasserin aut Varon, D. verfasserin aut Martinowitz, U. oth Heim, M. oth RODRIGUEZ-MERCHAN, E. C. oth In Haemophilia Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925867 (DE-600)2006344-1 1365-2516 nnns volume:4 year:1998 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 4 0 |
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10.1046/j.1365-2516.1998.440506.x doi (DE-627)NLEJ242796923 DE-627 ger DE-627 rakwb Lee, C. A. verfasserin aut The destructive capabilities of the synovium in the haemophilic joint Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Synovium Kessler, C. M. verfasserin aut Varon, D. verfasserin aut Martinowitz, U. oth Heim, M. oth RODRIGUEZ-MERCHAN, E. C. oth In Haemophilia Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925867 (DE-600)2006344-1 1365-2516 nnns volume:4 year:1998 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 4 0 |
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10.1046/j.1365-2516.1998.440506.x doi (DE-627)NLEJ242796923 DE-627 ger DE-627 rakwb Lee, C. A. verfasserin aut The destructive capabilities of the synovium in the haemophilic joint Oxford, UK Blackwell Science Ltd 1998 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. 2003 Blackwell Publishing Journal Backfiles 1879-2005 |2003|||||||||| Synovium Kessler, C. M. verfasserin aut Varon, D. verfasserin aut Martinowitz, U. oth Heim, M. oth RODRIGUEZ-MERCHAN, E. C. oth In Haemophilia Oxford [u.a.] : Wiley-Blackwell, 1995 4(1998), 4, Seite 0 Online-Ressource (DE-627)NLEJ243925867 (DE-600)2006344-1 1365-2516 nnns volume:4 year:1998 number:4 pages:0 http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 4 1998 4 0 |
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Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. |
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Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. |
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Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242796923</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20210707164210.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s1998 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1046/j.1365-2516.1998.440506.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242796923</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Lee, C. A.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">The destructive capabilities of the synovium in the haemophilic joint</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Science Ltd</subfield><subfield code="c">1998</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Summary. The pathogenesis of chronic haemophilic synovitis and the destructive capabilities of the synovium are multifactorial. As a result of repeated haemarthroses, synovial hyperthrophy occurs, iron and cellular debris are phagocytized, and hydrolitic enzymes synthesized by the proliferating synovium are released into the joint. An inflammatory process develops, and the nutrition of the articular cartilage is affected by the abnormal synovial fluid, immobilization of the joint, and the presence of fibrous adhesions. Chronic hyperthrophic synovitis is a progressive destructive condition in the joint and, unless it is treated, the joint is doomed. With the development of cartilaginous destruction, progressive chondrolisis and eventual osteoarthritis set in.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2003</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2003||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Synovium</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Kessler, C. M.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Varon, D.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Martinowitz, U.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Heim, M.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">RODRIGUEZ-MERCHAN, E. C.</subfield><subfield code="4">oth</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="t">Haemophilia</subfield><subfield code="d">Oxford [u.a.] : Wiley-Blackwell, 1995</subfield><subfield code="g">4(1998), 4, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243925867</subfield><subfield code="w">(DE-600)2006344-1</subfield><subfield code="x">1365-2516</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:4</subfield><subfield code="g">year:1998</subfield><subfield code="g">number:4</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1046/j.1365-2516.1998.440506.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">4</subfield><subfield code="j">1998</subfield><subfield code="e">4</subfield><subfield code="h">0</subfield></datafield></record></collection>
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