Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence
Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to...
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| Autor*in: |
Sleator, Roy D [verfasserIn] Hill, Colin [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 2002 |
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| Umfang: |
Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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| Übergeordnetes Werk: |
In: FEMS microbiology reviews - Federation of European Microbiological Societies ; GKD-ID: 114439X, Oxford : Wiley-Blackwell, 1985, 26(2002), 1, Seite 0 |
| Übergeordnetes Werk: |
volume:26 ; year:2002 ; number:1 ; pages:0 |
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| DOI / URN: |
10.1111/j.1574-6976.2002.tb00598.x |
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| 520 | |a Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. | ||
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10.1111/j.1574-6976.2002.tb00598.x doi (DE-627)NLEJ242867375 DE-627 ger DE-627 rakwb Sleator, Roy D verfasserin aut Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Osmoadaptation Hill, Colin verfasserin aut In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS microbiology reviews Oxford : Wiley-Blackwell, 1985 26(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ243926707 (DE-600)1500468-5 1574-6976 nnns volume:26 year:2002 number:1 pages:0 http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 2002 1 0 |
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10.1111/j.1574-6976.2002.tb00598.x doi (DE-627)NLEJ242867375 DE-627 ger DE-627 rakwb Sleator, Roy D verfasserin aut Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Osmoadaptation Hill, Colin verfasserin aut In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS microbiology reviews Oxford : Wiley-Blackwell, 1985 26(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ243926707 (DE-600)1500468-5 1574-6976 nnns volume:26 year:2002 number:1 pages:0 http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 2002 1 0 |
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10.1111/j.1574-6976.2002.tb00598.x doi (DE-627)NLEJ242867375 DE-627 ger DE-627 rakwb Sleator, Roy D verfasserin aut Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Osmoadaptation Hill, Colin verfasserin aut In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS microbiology reviews Oxford : Wiley-Blackwell, 1985 26(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ243926707 (DE-600)1500468-5 1574-6976 nnns volume:26 year:2002 number:1 pages:0 http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 2002 1 0 |
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10.1111/j.1574-6976.2002.tb00598.x doi (DE-627)NLEJ242867375 DE-627 ger DE-627 rakwb Sleator, Roy D verfasserin aut Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Osmoadaptation Hill, Colin verfasserin aut In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS microbiology reviews Oxford : Wiley-Blackwell, 1985 26(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ243926707 (DE-600)1500468-5 1574-6976 nnns volume:26 year:2002 number:1 pages:0 http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 2002 1 0 |
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10.1111/j.1574-6976.2002.tb00598.x doi (DE-627)NLEJ242867375 DE-627 ger DE-627 rakwb Sleator, Roy D verfasserin aut Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Osmoadaptation Hill, Colin verfasserin aut In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS microbiology reviews Oxford : Wiley-Blackwell, 1985 26(2002), 1, Seite 0 Online-Ressource (DE-627)NLEJ243926707 (DE-600)1500468-5 1574-6976 nnns volume:26 year:2002 number:1 pages:0 http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 2002 1 0 |
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Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. |
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Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. |
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Two general strategies exist for the growth and survival of prokaryotes in environments of elevated osmolarity. The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria. |
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The ‘salt in cytoplasm’ approach, which requires extensive structural modifications, is restricted mainly to members of the Halobacteriaceae. All other species have convergently evolved to cope with environments of elevated osmolarity by the accumulation of a restricted range of low molecular mass molecules, termed compatible solutes owing to their compatibility with cellular processes at high internal concentrations. Herein we review the molecular mechanisms governing the accumulation of these compounds, both in Gram-positive and Gram-negative bacteria, focusing specifically on the regulation of their transport/synthesis systems and the ability of these systems to sense and respond to changes in the osmolarity of the extracellular environment. Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria.</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="d">2006</subfield><subfield code="f">Blackwell Publishing Journal Backfiles 1879-2005</subfield><subfield code="7">|2006||||||||||</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Osmoadaptation</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Hill, Colin</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="773" ind1="0" ind2="8"><subfield code="i">In</subfield><subfield code="a">Federation of European Microbiological Societies ; GKD-ID: 114439X</subfield><subfield code="t">FEMS microbiology reviews</subfield><subfield code="d">Oxford : Wiley-Blackwell, 1985</subfield><subfield code="g">26(2002), 1, Seite 0</subfield><subfield code="h">Online-Ressource</subfield><subfield code="w">(DE-627)NLEJ243926707</subfield><subfield code="w">(DE-600)1500468-5</subfield><subfield code="x">1574-6976</subfield><subfield code="7">nnns</subfield></datafield><datafield tag="773" ind1="1" ind2="8"><subfield code="g">volume:26</subfield><subfield code="g">year:2002</subfield><subfield code="g">number:1</subfield><subfield code="g">pages:0</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://dx.doi.org/10.1111/j.1574-6976.2002.tb00598.x</subfield><subfield code="q">text/html</subfield><subfield code="x">Verlag</subfield><subfield code="z">Deutschlandweit zugänglich</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_USEFLAG_U</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-1-DJB</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_NL_ARTICLE</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">AR</subfield></datafield><datafield tag="952" ind1=" " ind2=" "><subfield code="d">26</subfield><subfield code="j">2002</subfield><subfield code="e">1</subfield><subfield code="h">0</subfield></datafield></record></collection>
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7.400302 |