Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection
Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mi...
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| Autor*in: |
Centeno-Lima, Sónia [verfasserIn] Silveira, Henrique [verfasserIn] Casimiro, Catarina [verfasserIn] |
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| Format: |
E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 2002 |
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Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: FEMS immunology and medical microbiology - Federation of European Microbiological Societies ; GKD-ID: 114439X, Oxford [u.a.] : Wiley-Blackwell, 1993, 32(2002), 2, Seite 0 |
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volume:32 ; year:2002 ; number:2 ; pages:0 |
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| DOI / URN: |
10.1111/j.1574-695X.2002.tb00549.x |
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10.1111/j.1574-695X.2002.tb00549.x doi (DE-627)NLEJ242927750 DE-627 ger DE-627 rakwb Centeno-Lima, Sónia verfasserin aut Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Th1/Th2 cytokine Silveira, Henrique verfasserin aut Casimiro, Catarina verfasserin aut Aguiar, Pedro oth Rosário, Virgílio E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 32(2002), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:32 year:2002 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.2002.tb00549.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2002 2 0 |
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10.1111/j.1574-695X.2002.tb00549.x doi (DE-627)NLEJ242927750 DE-627 ger DE-627 rakwb Centeno-Lima, Sónia verfasserin aut Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Th1/Th2 cytokine Silveira, Henrique verfasserin aut Casimiro, Catarina verfasserin aut Aguiar, Pedro oth Rosário, Virgílio E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 32(2002), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:32 year:2002 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.2002.tb00549.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2002 2 0 |
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10.1111/j.1574-695X.2002.tb00549.x doi (DE-627)NLEJ242927750 DE-627 ger DE-627 rakwb Centeno-Lima, Sónia verfasserin aut Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Th1/Th2 cytokine Silveira, Henrique verfasserin aut Casimiro, Catarina verfasserin aut Aguiar, Pedro oth Rosário, Virgílio E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 32(2002), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:32 year:2002 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.2002.tb00549.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2002 2 0 |
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10.1111/j.1574-695X.2002.tb00549.x doi (DE-627)NLEJ242927750 DE-627 ger DE-627 rakwb Centeno-Lima, Sónia verfasserin aut Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Th1/Th2 cytokine Silveira, Henrique verfasserin aut Casimiro, Catarina verfasserin aut Aguiar, Pedro oth Rosário, Virgílio E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 32(2002), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:32 year:2002 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.2002.tb00549.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2002 2 0 |
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10.1111/j.1574-695X.2002.tb00549.x doi (DE-627)NLEJ242927750 DE-627 ger DE-627 rakwb Centeno-Lima, Sónia verfasserin aut Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection Oxford, UK Blackwell Publishing Ltd 2002 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| Th1/Th2 cytokine Silveira, Henrique verfasserin aut Casimiro, Catarina verfasserin aut Aguiar, Pedro oth Rosário, Virgílio E. oth In Federation of European Microbiological Societies ; GKD-ID: 114439X FEMS immunology and medical microbiology Oxford [u.a.] : Wiley-Blackwell, 1993 32(2002), 2, Seite 0 Online-Ressource (DE-627)NLEJ243926014 (DE-600)1500464-8 1574-695X nnns volume:32 year:2002 number:2 pages:0 http://dx.doi.org/10.1111/j.1574-695X.2002.tb00549.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 32 2002 2 0 |
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Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection |
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Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. |
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Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. |
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Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. These results confirm the importance of Th1 dependent immunity against invasive aspergillosis. |
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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a22002652 4500</leader><controlfield tag="001">NLEJ242927750</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230505190916.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">120427s2002 xx |||||o 00| ||und c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1111/j.1574-695X.2002.tb00549.x</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)NLEJ242927750</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rakwb</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Centeno-Lima, Sónia</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Kinetics of cytokine expression in mice with invasive aspergillosis: lethal infection and protection</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Oxford, UK</subfield><subfield code="b">Blackwell Publishing Ltd</subfield><subfield code="c">2002</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zzz</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">z</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">nicht spezifiziert</subfield><subfield code="b">zu</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Aspergillus fumigatus causes lethal invasive aspergillosis in cortisone-treated mice while immunized mice are protected. Kinetics of interferon (IFN)-γ, tumor necrosis factor-α, interleukin (IL)-12p40, IL-4 and IL-10 expression were assessed by reverse transcription-PCR in the spleen and lungs of mice. After immunization, mice were protected from otherwise lethal infection, with concomitant high expression levels of IFN-γ early in the lungs and later in the spleen. In the lethal infection model cortisone-treated infected mice presented high expression levels of IL-10 in the spleen and in the lungs. Immunocompetent mice were able to control the disease and presented earlier expression of IL-12p40 and IFN-γ in lungs and spleen. 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