Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.

Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. Ausführliche Beschreibung

Gespeichert in:

Autor*in:	Vivien-Roels, B. [verfasserIn] Pévet, P. [verfasserIn] Zarazaga, L. [verfasserIn] Malpaux, B. Chemineau, P.

Format:	E-Artikel

Erschienen:	Oxford, UK: Blackwell Publishing Ltd ; 1999

Schlagwörter:	daily rhythm

Umfang:	Online-Ressource

Reproduktion:	2007 ; Blackwell Publishing Journal Backfiles 1879-2005
Übergeordnetes Werk:	In: Journal of pineal research - Oxford [u.a.] : Wiley-Blackwell, 1984, 27(1999), 4, Seite 0
Übergeordnetes Werk:	volume:27 ; year:1999 ; number:4 ; pages:0

Links:	Volltext

DOI / URN:	10.1111/j.1600-079X.1999.tb00620.x

Katalog-ID:	NLEJ242995888

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245	1	0	\|a Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.
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520			\|a Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined.
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allfields	10.1111/j.1600-079X.1999.tb00620.x doi (DE-627)NLEJ242995888 DE-627 ger DE-627 rakwb Vivien-Roels, B. verfasserin aut Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion. Oxford, UK Blackwell Publishing Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| daily rhythm Pévet, P. verfasserin aut Zarazaga, L. verfasserin aut Malpaux, B. oth Chemineau, P. oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 27(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:27 year:1999 number:4 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 1999 4 0
spelling	10.1111/j.1600-079X.1999.tb00620.x doi (DE-627)NLEJ242995888 DE-627 ger DE-627 rakwb Vivien-Roels, B. verfasserin aut Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion. Oxford, UK Blackwell Publishing Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| daily rhythm Pévet, P. verfasserin aut Zarazaga, L. verfasserin aut Malpaux, B. oth Chemineau, P. oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 27(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:27 year:1999 number:4 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 1999 4 0
allfields_unstemmed	10.1111/j.1600-079X.1999.tb00620.x doi (DE-627)NLEJ242995888 DE-627 ger DE-627 rakwb Vivien-Roels, B. verfasserin aut Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion. Oxford, UK Blackwell Publishing Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| daily rhythm Pévet, P. verfasserin aut Zarazaga, L. verfasserin aut Malpaux, B. oth Chemineau, P. oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 27(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:27 year:1999 number:4 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 1999 4 0
allfieldsGer	10.1111/j.1600-079X.1999.tb00620.x doi (DE-627)NLEJ242995888 DE-627 ger DE-627 rakwb Vivien-Roels, B. verfasserin aut Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion. Oxford, UK Blackwell Publishing Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| daily rhythm Pévet, P. verfasserin aut Zarazaga, L. verfasserin aut Malpaux, B. oth Chemineau, P. oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 27(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:27 year:1999 number:4 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 1999 4 0
allfieldsSound	10.1111/j.1600-079X.1999.tb00620.x doi (DE-627)NLEJ242995888 DE-627 ger DE-627 rakwb Vivien-Roels, B. verfasserin aut Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion. Oxford, UK Blackwell Publishing Ltd 1999 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined. 2007 Blackwell Publishing Journal Backfiles 1879-2005 \|2007\|\|\|\|\|\|\|\|\|\| daily rhythm Pévet, P. verfasserin aut Zarazaga, L. verfasserin aut Malpaux, B. oth Chemineau, P. oth In Journal of pineal research Oxford [u.a.] : Wiley-Blackwell, 1984 27(1999), 4, Seite 0 Online-Ressource (DE-627)NLEJ243926731 (DE-600)2027992-9 1600-079X nnns volume:27 year:1999 number:4 pages:0 http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 27 1999 4 0
source	In Journal of pineal research 27(1999), 4, Seite 0 volume:27 year:1999 number:4 pages:0
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To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. 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series2	Blackwell Publishing Journal Backfiles 1879-2005
author	Vivien-Roels, B.
spellingShingle	Vivien-Roels, B. misc daily rhythm Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.
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topic_title	Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion daily rhythm
publisher	Blackwell Publishing Ltd
publisherStr	Blackwell Publishing Ltd
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title	Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.
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title_full	Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion
author_sort	Vivien-Roels, B.
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author_browse	Vivien-Roels, B. Pévet, P. Zarazaga, L.
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author-letter	Vivien-Roels, B.
doi_str_mv	10.1111/j.1600-079X.1999.tb00620.x
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title_sort	daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ml) in ewes with respectively high and low nocturnal melatonin secretion
title_auth	Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.
abstract	Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined.
abstractGer	Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined.
abstract_unstemmed	Abstract: The aim of the present study was to determine whether the genetic differences previously reported in ewe plasma melatonin concentrations were correlated with differences in the synthesis and release of other 5-methoxyindoles. To determine if 5-methoxytryptophol (5-ML), which is known to be present in large amounts in the sheep pineal gland, is released, as is melatonin, into the general circulation, and if some temporal relationships between 5-ML and melatonin release could be observed, two groups of ewes were selected with respect to their endogenous melatonin secretion: in the first experiment, ten ewes from the low melatonin group (low group) and ten ewes from the high melatonin group (high group). 5-ML was measured every hour during a 24-hr period by radioimmunoassay. In all ewes, 5-ML was released during day-time, the rhythm of 5-ML concentrations being inversely related with the melatonin rhythm. Both day-time and night-time 5-ML concentrations were higher in the ewes from the high group than in the ewes from the low group (14.7 ± 1.0 pg/mL plasma versus 6.4 ± 0.3 pg/mL plasma during the day, 3.1 ± 0.2 pg/mL plasma versus 1.9 ± 0.2 pg/mL plasma during the night). The 5-ML/melatonin ratio appeared much higher during the day than during the night but was very similar in both groups (day-time: 1.03 in the high group versus 1.16 in the low group, night-time: 0.01 in both groups). In a second experiment, six low group and seven high group ewes were submitted to 1 hr of extra light at night. 5-ML increased and melatonin decreased during extra light. Our results clearly show for the first time a daily variation in circulating 5-ML. and that the strong genetic contribution in the variability in melatonin concentrations in sheep are clearly correlated with a similar variability in 5-ML concentrations. Whether 5-ML, like melatonin, plays a physiological role in the different adaptation processes to the environment remains to be determined.
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title_short	Daily and light-at-night induced variations of circulating 5-methoxytryptophol (5-ML) in ewes with respectively high and low nocturnal melatonin secretion.
url	http://dx.doi.org/10.1111/j.1600-079X.1999.tb00620.x
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author2	Pévet, P. Zarazaga, L. Malpaux, B. Chemineau, P.
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up_date	2024-07-06T03:56:37.092Z
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