p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study
We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within th...
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E-Artikel |
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| Erschienen: |
Oxford, UK: Blackwell Publishing Ltd ; 1997 |
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Online-Ressource |
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| Reproduktion: |
2006 ; Blackwell Publishing Journal Backfiles 1879-2005 |
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In: Journal of oral pathology & medicine - Oxford [u.a.] : Wiley-Blackwell, 1972, 26(1997), 7, Seite 0 |
| Übergeordnetes Werk: |
volume:26 ; year:1997 ; number:7 ; pages:0 |
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| DOI / URN: |
10.1111/j.1600-0714.1997.tb00222.x |
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| 520 | |a We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. | ||
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| 700 | 1 | |a Riethdorf, Sabine |4 oth | |
| 700 | 1 | |a Friedrich, Reinhard E. |4 oth | |
| 700 | 1 | |a Ostwald, Christians |4 oth | |
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| 700 | 1 | |a Schlechte, Horst |4 oth | |
| 700 | 1 | |a Becker, Jürgen |4 oth | |
| 700 | 1 | |a Bregenzer, Thomas |4 oth | |
| 700 | 1 | |a Riethdorf, Lutz |4 oth | |
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10.1111/j.1600-0714.1997.tb00222.x doi (DE-627)NLEJ243040784 DE-627 ger DE-627 rakwb p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| head and neck squamous cell carcinoma (HNSCC) Riethdorf, Sabine oth Friedrich, Reinhard E. oth Ostwald, Christians oth Batten, Malte oth Gogacz, Pawei oth Gundlach, Karsten K. H. oth Schlechte, Horst oth Becker, Jürgen oth Bregenzer, Thomas oth Riethdorf, Lutz oth Löning, Thomas oth In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 26(1997), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:26 year:1997 number:7 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 1997 7 0 |
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10.1111/j.1600-0714.1997.tb00222.x doi (DE-627)NLEJ243040784 DE-627 ger DE-627 rakwb p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| head and neck squamous cell carcinoma (HNSCC) Riethdorf, Sabine oth Friedrich, Reinhard E. oth Ostwald, Christians oth Batten, Malte oth Gogacz, Pawei oth Gundlach, Karsten K. H. oth Schlechte, Horst oth Becker, Jürgen oth Bregenzer, Thomas oth Riethdorf, Lutz oth Löning, Thomas oth In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 26(1997), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:26 year:1997 number:7 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 1997 7 0 |
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10.1111/j.1600-0714.1997.tb00222.x doi (DE-627)NLEJ243040784 DE-627 ger DE-627 rakwb p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| head and neck squamous cell carcinoma (HNSCC) Riethdorf, Sabine oth Friedrich, Reinhard E. oth Ostwald, Christians oth Batten, Malte oth Gogacz, Pawei oth Gundlach, Karsten K. H. oth Schlechte, Horst oth Becker, Jürgen oth Bregenzer, Thomas oth Riethdorf, Lutz oth Löning, Thomas oth In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 26(1997), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:26 year:1997 number:7 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 1997 7 0 |
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10.1111/j.1600-0714.1997.tb00222.x doi (DE-627)NLEJ243040784 DE-627 ger DE-627 rakwb p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| head and neck squamous cell carcinoma (HNSCC) Riethdorf, Sabine oth Friedrich, Reinhard E. oth Ostwald, Christians oth Batten, Malte oth Gogacz, Pawei oth Gundlach, Karsten K. H. oth Schlechte, Horst oth Becker, Jürgen oth Bregenzer, Thomas oth Riethdorf, Lutz oth Löning, Thomas oth In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 26(1997), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:26 year:1997 number:7 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 1997 7 0 |
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10.1111/j.1600-0714.1997.tb00222.x doi (DE-627)NLEJ243040784 DE-627 ger DE-627 rakwb p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study Oxford, UK Blackwell Publishing Ltd 1997 Online-Ressource nicht spezifiziert zzz rdacontent nicht spezifiziert z rdamedia nicht spezifiziert zu rdacarrier We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. 2006 Blackwell Publishing Journal Backfiles 1879-2005 |2006|||||||||| head and neck squamous cell carcinoma (HNSCC) Riethdorf, Sabine oth Friedrich, Reinhard E. oth Ostwald, Christians oth Batten, Malte oth Gogacz, Pawei oth Gundlach, Karsten K. H. oth Schlechte, Horst oth Becker, Jürgen oth Bregenzer, Thomas oth Riethdorf, Lutz oth Löning, Thomas oth In Journal of oral pathology & medicine Oxford [u.a.] : Wiley-Blackwell, 1972 26(1997), 7, Seite 0 Online-Ressource (DE-627)NLEJ243927231 (DE-600)2026385-5 1600-0714 nnns volume:26 year:1997 number:7 pages:0 http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x text/html Verlag Deutschlandweit zugänglich Volltext GBV_USEFLAG_U ZDB-1-DJB GBV_NL_ARTICLE AR 26 1997 7 0 |
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p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study |
| abstract |
We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. |
| abstractGer |
We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. |
| abstract_unstemmed |
We analyzed specimens of head and neck squamous cell carcinomas (HNSCC) from 110 patients for p53 gene mutations, and 92 of them for human papillomavirus (HPV) infection, in order to evaluate the prognostic significance of these factors by comparison with clinical follow-up data. Mutations within the exons 5 to 8 of the p53 gene were found in 48 tumors (44%). Sequencing revealed in most cases mis-sense mutations (16/21). Frequency of p53 gene mutations was not related to the tumor stage or the presence of lymph node metastases. Of the 46 tumors that were analyzed by immunohistochemistry. 26 stained positively (56%). The number of positively stained nuclei increased slightly with decreasing differentiation of the tumors, whereas no correlation was found between tumor stage and immunoreactivity. An infection with the high-risk HPV types 16 and 18 could be detected in 39/92 tumor specimens (42%.). Follow-up data were obtained from 99 patients within a range of 2 to 112 months. No dependence of overall survival on the presence of p53 gene mutations or HPV infection could be observed. The absence of statistically significant correlations between p53 gene mutation and progressive disease, however, does not deny its putative relevance in early phases of tumor development. |
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| title_short |
p53 gene mutations and HPV infection in primary head and neck squamous cell carcinomas do not correlate with overall survival: a long term follow-up study |
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http://dx.doi.org/10.1111/j.1600-0714.1997.tb00222.x |
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Riethdorf, Sabine Friedrich, Reinhard E. Ostwald, Christians Batten, Malte Gogacz, Pawei Gundlach, Karsten K. H. Schlechte, Horst Becker, Jürgen Bregenzer, Thomas Riethdorf, Lutz Löning, Thomas |
| author2Str |
Riethdorf, Sabine Friedrich, Reinhard E. Ostwald, Christians Batten, Malte Gogacz, Pawei Gundlach, Karsten K. H. Schlechte, Horst Becker, Jürgen Bregenzer, Thomas Riethdorf, Lutz Löning, Thomas |
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10.1111/j.1600-0714.1997.tb00222.x |
| up_date |
2024-07-06T04:04:36.756Z |
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